melophlins c-o, thirteen novel tetramic acids from the marine sponge melophlus sarassinorum.thirteen new metabolites, melophlins c-o (1-13), were identified from the marine sponge melophlus sarassinorum. compounds 1-13 represent tetramic acid derivatives that differ with regard to the nature of their alkyl side chains. the structures of the new compounds were elucidated on the basis of comprehensive spectral analysis (1h, 13c, 1h-1h cosy, hmqc, and hmbc nmr, as well as low- and high-resolution esims and eims). the absolute configurations of 1, 8, 10, 11, 12, and 13 were determined by e ...200312542345
new macrolides from the sponge chondrosia corticata.three new oxazole-containing metabolites, neohalichondramide (5), (19z)-halichondramide (6), and secohalichondramide (7), along with four previously reported compounds of the same structural class were isolated from the marine sponge chondrosia corticata collected from guam. the structures of novel compounds were determined on the basis of combined spectroscopic analyses. these compounds exhibited significant cytotoxicity and antifungal activity toward the human leukemia cell-line k562 and candi ...200415568783
new steroidal alkaloids from an undescribed sponge of the genus corticium.two new steroidal alkaloids, along with a previously reported one of the plakinamine class, were isolated from the sponge corticium sp. collected from guam. the structures of the new compounds were determined by combined spectroscopic methods. these compounds exhibited moderate cytotoxicity and antifungal activity as well as dna- and rna-cleaving activities.200111720539
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