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stool viruses in babies in glasgow 2. investigation of normal newborns in hospital.the stools of 37 newborn babies born in hospital were examined for the presence of virus. an extract of every stool passed by each baby was examined in the electron microscopy and inoculated into cell cultures. the babies were delivered in four separate maternity units (a-d). all the babies from unit a and c(9 babies) were found to be excreting rotavirus though none showed any evidence of diarrhoea. two of the babies also excreted astrovirus. subsequently unit a was closed for cleaning and, on r ...1978212478
stool viruses in babies in glasgow. i. hospital admissions with diarrhoea.stools from 183 babies under 2 years of age admitted to ruchill hospital with diarrhoea were examined by electron microscopy, virus culture, bacterial culture and light microscopy. as far as possible, several stools were examined from each patient and the results showed rotaviruses, astroviruses and other viruses in association with symptoms, as well as the expected bacterial pathogens. examination of several stools from the same patient also showed that in this age group the viral flora of the ...1977403233
a survey of rotaviruses in sheep in scotland. 1977867760
rapid random-donor screening for the selection of viral antibody-containing blood donations.we describe a 3 1/2 year trial in which we used immunofluorescence to detect and titrate antibody to six common viruses in normal healthy blood donors drawn at random from west and south east scotland. the trial was designed to allow selection of blood donations rich in specific antiviral antibody for inclusion in the plasma pool which would, in turn, be used for the preparation of specific antiviral immunoglobulin. the results show the natural frequency of occurrence of antibody to different vi ...19806255854
molecular epidemiology of human rotaviruses. analysis of outbreaks of acute gastroenteritis in glasgow and the west of scotland 1981/82 and 1982/83.the molecular epidemiology of rotavirus infections in glasgow and the west of scotland during 1981/82 and 1982/83 was investigated by electron microscopy, elisa testing and rna migration pattern analysis. in 1981/82, rotaviruses of both the 'long' and the 'short' electropherotype (in different variants) co-circulated from the onset throughout the winter peak of the outbreak. approximately 80% of the children were infected during the first year of life. no differences in incidence were found betw ...19846323577
an estimate of the costs of cases of rotavirus infection admitted to hospital in scotland, 1997. 200112664759
first rotavirus, now astrovirus: the evolving benefits of rt-pcr.we compared rt-pcr and a newly developed amplified eia for the detection of human astrovirus (hastv) in 48 stool samples taken from children of less than five years of age with gastroenteritis. the rt-pcr classified more samples as positive than the eia (18 versus 8). without sensitive diagnosis, infection control policies will be disadvantaged and the true economic burden of hastv underestimated.200312736977
a study of enterovirus isolations in glasgow from 1977 to 1997.the number and range of enteroviruses isolated in the regional virus laboratory, glasgow during 1977-1997 was determined. over this period, 3,039 enterovirus isolations were reported. the echoviruses represented 67% of isolations with echovirus 4 (due to an outbreak in 1990), echovirus 30 and echovirus 11 being the most frequently isolated types. the pattern of prevalence of non-polio enteroviruses had changed from the previous 20-year period with echovirus types isolated more often (77% vs. 55. ...199910447428
molecular epidemiology of human rotavirus.the epidemiology of human rotavirus (hrv) in north-east scotland was investigated between 1982 and 1984. during this period 708 hrv infections were recorded. the majority (83%) of the infections were in children less than 5 years of age although some were recorded in adults. the peak incidence occurred in the winter months although a high number of hrv infections was reported during the summer of 1983. a total of 840 faecal specimens containing rotavirus were screened for hrv genome rna by polya ...19863701041
genome analysis of human rotaviruses by oligonucleotide mapping of isolated rna segments.the genomes of adult diarrhoea rotaviruses isolated in different parts of china during winter outbreaks in 1983 and 1984 were compared by segmental oligonucleotide (on) mapping. the rna profiles of most of the isolates were indistinguishable but it was found that some corresponding rna segments had identical or very closely related on maps whereas others differed considerably. this finding can be taken to suggest that the strains compared may be genetically related by a natural reassortment even ...19863014782
occurrence and properties of fy(att25)+ escherichia coli associated with diarrhoea in calves.escherichia coli producing the adhesive antigen fy(att25) were isolated from 46 of 1341 (3.4 per cent) e coli isolated from calves on 20 of 164 (12.1 per cent) farms in scotland and england. twenty of the 46 calves had diarrhoea and in nine of these animals there were mixed infections with rotavirus, coronavirus, cryptosporidium and salmonella typhimurium. the f41 fimbrial adhesin was found on one of the fy(att25)+ e coli. this strain also produced heat stable enterotoxin. the remaining fy(att25 ...19872889286
burden on uk secondary care of rotavirus disease and seasonal infections in children.rotavirus is a common infection affecting children under 5 years, which leads to a significant disease burden. this burden is potentially exacerbated by the seasonality of rotavirus, particularly in the context of the seasonality of other common childhood infections. the primary study objective was to describe the pattern and burden of seasonal infections amongst children under 5 years of age with particular attention placed on rotavirus and other gastrointestinal infections.201020818925
temperature-dependent transmission of rotavirus in great britain and the netherlands.in europe, rotavirus gastroenteritis peaks in late winter or early spring suggesting a role for weather factors in transmission of the virus. in this study, multivariate regression models adapted for time-series data were used to investigate effects of temperature, humidity and rainfall on reported rotavirus infections and the infection-rate parameter, a derived measure of infection transmission that takes into account population immunity, in england, wales, scotland and the netherlands. delayed ...201019939844
rotavirus in red squirrels from scotland. 200919820262
oral polio vaccine and intussusception: a data linkage study using records for vaccination and hospitalization.the authors investigated the possibility of an association between oral polio vaccine (opv) and intussusception by linking scottish vaccination and hospitalization data sets and performing self-controlled case series analysis. the issue was important because rotavirus vaccine, another live oral virus vaccine, was withdrawn from the market in 1999 after studies showed a strong association with intussusception. opv was recommended for all infants in the united kingdom at ages 2, 3, and 4 months un ...200616467416
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