population-based estimates of the cumulative risk of hospitalization potentially associated with rotavirus diarrhea among children living in two cities in akita prefecture, japan.a 4-year retrospective population-based survey was conducted in two cities in akita prefecture, japan, to estimate the incidence rate and the cumulative risk of hospitalization potentially associated with rotavirus diarrhea. at monthly occasions of the 3-year-old checkup, we asked each parent if his or her child had ever been hospitalized because of rotavirus diarrhea. based on 3-year follow-up of the four consecutive birth cohorts (1996-1999), we calculated the incidence rate and the cumulative ...200515858283
a lack of significant association between the electropherotype or g-serotype of the infecting strain and disease severity of rotavirus gastroenteritis.despite many previous studies, the question has not been settled as to whether some human rotavirus strains are more virulent than others. since disease severity is most clearly reflected by the hospitalization status of the infected children, we examined whether there was any difference in the distribution of dominant strains between inpatient and outpatient groups. the study population comprised 763 children with acute diarrhea who were treated at a general hospital in honjo city, akita, japan ...200616680579
incidence and burden of rotavirus gastroenteritis in japan, as estimated from a prospective sentinel hospital study.we assessed the burden of rotavirus infection-related disease, in terms of hospitalization and associated costs, at 3 sentinel hospitals in akita prefecture, japan. from january 2001 through december 2002, a total of 443 children <5 years of age were hospitalized for acute gastroenteritis. of 422 stool specimens collected, 244 (58%) tested positive for rotavirus. only 7.8% of the rotavirus disease-associated hospitalizations involved infants <6 months of age, whereas most cases of disease (39%) ...200516088792
the relative frequencies of g serotypes of rotaviruses recovered from hospitalized children with diarrhea: a 10-year survey (1987-1996) in japan with a review of globally collected data.since rotavirus vaccines aim to protect children from severe diarrhea, knowledge of the prevailing g serotypes among rotaviruses from hospitalized children is essential. thus, we determined the g serotypes of rotaviruses collected from children with acute diarrhea in a local referral hospital in akita, japan, over the 10-year period between january 1987 and december 1996. based on the assumption that rotaviruses with an identical electropherotype possess the same g serotype, the g serotypes of 4 ...200010941933
molecular identification of a novel human rotavirus in relation to subgroup and electropherotype of genomic rna.a total of 41 stool rotavirus specimens collected from children with acute diarrhea at four different locations in akita prefecture, japan, during the peak of the winter diarrhea epidemic in 1988 were analyzed by polyacrylamide gel electrophoresis of viral rna in conjunction with subgrouping assay. we found that a single strain predominated, with cocirculating strains with less common electropherotypes at a given location, and that two different strains could predominate at geographically close ...19892547020
rotavirus hospitalization and molecular epidemiology in northern japan, 1987-1996.anticipating rotavirus vaccine in japan, we examined long-term trends in rotavirus hospitalizations and characterized circulating strains. rotavirus was detected in 974 children aged <5 years hospitalized for acute gastroenteritis in akita between 1987 and 1996. the unadjusted incidence rate of rotavirus hospitalizations was 14.9 per 1000 child-years. in 9 out of 11 seasons g1p[8] was the most frequent genotype averaging 75%, but g2p[4] accounted for 87% of genotypes in 1 season. interestingly, ...200919931729
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