Publications

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construction and characterization of a full-length infectious clone from a fast-replicating, x4-tropic hiv-1 subtype b' isolate.in hiv-1 epidemics in china, hiv-1 subtype b' is the most predominant subtype circulating in intravenous drug users. in this study, we constructed an hiv-1 full-length infectious molecular clone based on the primary virus lwj, which was isolated from an hiv-infected patient in fujian province, china. phylogenetic and bootscanning analysis of the viral sequence revealed that the isolate lwj belonged to hiv-1 subtype b'. the infectious clone was designated as "plwj". the virus (lwj-c) produced fro ...201020697919
systematic review of hiv and hcv infection among drug users in china.to determine the hiv and hepatitis c virus (hcv) geographical distribution among drug users in china, a systematic literature review of 40 peer-reviewed publications (comprising 15,565 drug users) was conducted. of the total drug users, 10,724 were found to be injection drug users (idus) and 4841 were non-injection drug users (non-idus). various studies identified that among idus and non-idus, the overall hiv prevalence rates were 12.55% and 1.05%, and the hcv prevalence rates were 66.97% and 18 ...200919451325
pharmacy workers' sexually transmitted diseases/human immunodeficiency virus knowledge in fuzhou, china: implications for human immunodeficiency virus testing, treatment, and prevention strategies.pharmacies play a special role in providing treatment services for patients with sexually transmitted diseases (stds) in china. there is a need to study the std/human immunodeficiency virus (hiv) knowledge among pharmacy workers in retail pharmacies.200919265742
[a cross-sectional case study of human immunodeficiency virus and tuberculosis co-infection in mainland china].in order to take an insight into the profile of hiv/aids and tuberculosis (tb) co-infection, we made a statistic survey in 9 hospitals in mainland china. with the purpose of guiding the prevention and treatment, 241 cases with such co-infection were enrolled and the data with respect to clinical manifestations, laboratory tests, therapy and prognosis were analysed.200717637263
herpes simplex virus 2 infection in women attending an antenatal clinic in fuzhou, china.genital herpes caused by herpes simplex virus (hsv) infection is one of the most prevalent sexually transmitted infections (stis) and the most common cause of genital ulcer disease (gud) in developed and developing countries. the monitoring of hsv-2 seroprevalence in pregnant women can identify women at a higher risk of hiv and of neonatal hsv transmission. very few data are available on type specific seroprevalence of hsv-2 in china, with only one previous study from southern china. consequentl ...200717475682
[sequence analysis of the full-length glycoprotein 120 gene of hiv-1 crf01_ae in fujian, china].to characterize full length glycoprotein 120 gene variations of 21 hiv-1 crf01_ae isolated in fujian, china, so as to help in the immunogenic research and vaccine design.200617313760
prevalence and partial sequence analysis of human t cell lymphotropic virus type i in china.a total of 145,293 serum samples were collected from volunteer blood donors in 13 provinces of china and tested for anti-htlv antibody using an elisa licensed in china. thirty were positive for anti-htlv by elisa and 19 of those 30 samples were confirmed positive using a supplemental immunoblot assay. anti-htlv-i was detected only in samples from fujian province (a southern province) where the positivity rate was approximately 0.05%. the region encoding gp46 from 5 of the 19 antibody positive sa ...200515977241
[analysis on the epidemic characterization and trend of aids in fujian province].to analysed the epidemic characterization and trend of aids in fujian province based on data obtained from hiv sero-survallance, hiv-1 subtyping and epidemiological survey.199910682509
genetic characterization of crf01_ae full-length human immunodeficiency virus type 1 sequences from fujian, china.hiv-1 crf01_ae is the main prevalent hiv-1 recombinant strain in china and the dominant strain in fujian as well; therefore, obtaining and understanding the genetic characterization of this clade become important. to date only a few full-length hiv-1 crf01_ae genomes from china have been sequenced. we reported 13 full-length hiv-1 crf01_ae isolate sequences from fujian, china. dna was extracted, the 5' and 3' halves of each genome were separately amplified, and the pcr products were cloned and s ...200717451347
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