Publications

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searching for the causes of gastric cancer. 200211892383
anthropology. where bacteria and languages concur. 200919164735
helicobacter pylori infection--gastritis, ulcers and gastric cancer. 19948045776
helicobacter pylori, pepsinogen, and gastric adenocarcinoma in hawaii.the objective was to investigate the association of helicobacter pylori and serum pepsinogen (pg) levels with gastric adenocarcinoma.200515897993
the peopling of the pacific from a bacterial perspective.two prehistoric migrations peopled the pacific. one reached new guinea and australia, and a second, more recent, migration extended through melanesia and from there to the polynesian islands. these migrations were accompanied by two distinct populations of the specific human pathogen helicobacter pylori, called hpsahul and hspmaori, respectively. hpsahul split from asian populations of h. pylori 31,000 to 37,000 years ago, in concordance with archaeological history. the hpsahul populations in ne ...200919164753
association of helicobacter pylori infection and diet on the risk of gastric cancer: a case-control study in hawaii.the risk factors most strongly associated with gastric cancer are the gastric bacteria helicobacter pylori and diet. utilizing data from a case-control study among residents in hawaii, we examined the association of diet, presence of h. pylori, and non-cardia gastric cancer risk.200818369531
gastric cancer among the japanese in hawaii.the incidence rate of gastric cancer among men of japanese ancestry living in hawaii is about one-third as high as that of their counterparts living in japan. because of this difference, a prospective study was conducted to identify factors related to the development of gastric cancer in hawaii. eight thousand and six (8,006) men born from 1900-1919 were examined from 1965 to 1968 and followed for over 25 years. during this time, 250 incident cases of gastric cancer were identified. the study ha ...19957493909
the association of helicobacter pylori with intestinal type gastric adenocarcinoma in a hawaii population.american-japanese in hawaii with gastric cancer have characteristics intermediate to those in japan and the mainland united states. japanese and mainland u.s. studies have found helicobacter pylori is associated with intestinal type gastric adenocarcinoma. the present hawaii study confirmed this association which is independent of japanese race (27.6% intestinal type and 4.5% diffuse type were h. pylori positive, p = 0.031, n = 80).19979447796
gastric carcinoma distal to the cardia: a review of the epidemiological pathology of the precusors to a preventable cancer.a distinctive gastritis precedes the development of cancer distal to the cardia. helicobacter pylori infection and the use of pickled foods as substitutes for fresh fruits and vegetables constitute the most important environmental factors that generate this gastritis. this review describes the anatomical changes that characterise the step-by-step evolution of a process that begins in childhood and culminates in invasive cancer in middle and old age. progression of the gastritis can be followed b ...200212555987
[case-control epidemiological studies: theoretical bases, variants and applications]. 200111381843
traces of human migrations in helicobacter pylori populations.helicobacter pylori, a chronic gastric pathogen of human beings, can be divided into seven populations and subpopulations with distinct geographical distributions. these modern populations derive their gene pools from ancestral populations that arose in africa, central asia, and east asia. subsequent spread can be attributed to human migratory fluxes such as the prehistoric colonization of polynesia and the americas, the neolithic introduction of farming to europe, the bantu expansion within afr ...200312624269
helicobacter pylori infection and gastric carcinoma among japanese americans in hawaii.helicobacter pylori are gram-negative spiral bacteria that are associated with chronic gastritis, a known precursor of gastric carcinoma. persons at high risk for gastric carcinoma have been shown to have a high prevalence of h. pylori infection.19911891021
is gastric carcinoma an infectious disease? 19911891027
relation between helicobacter pylori caga status and risk of peptic ulcer disease.although colonization with any helicobacter pylori strain is associated with peptic ulcer, it is uncertain whether the risk is greater with caga(+) or caga(-) strains, which differ in their biology. a nested case-control study was done, based on a cohort of 5,443 japanese-american men examined on the hawaiian island of oahu from 1967 to 1970. a total of 150 men with gastric ulcer, 65 with duodenal ulcer, and 14 with both diseases were identified. the authors matched the 229 cases with 229 popula ...200212034584
evidence for ethnic tropism of helicobacter pylori.helicobacter pylori infection in humans is linked to gastritis, gastric and duodenal ulcers, and gastric cancer. peptic ulcer disease, as distinct from chronic asymptomatic infection, is strongly associated with expression of bacterial virulence markers, including a major antigen, caga, and the vacuolating cytotoxin vaca. we have previously described significant differences in colonization rates, independent of socioeconomic status, among ethnic groups in new zealand. to evaluate relative risks ...19979284141
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