Publications

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survival of measles virus in air. 196414191599
the survival of measles virus in air, in relation to the epidemiology of measles. 196514322937
measles vaccines. 19694918530
clinical trial of live measles vaccine given alone and live vaccine preceded by killed vaccine. fourth report to the medical research council by the measles sub-committee of the committee on development of vaccines and immunisation procedures.follow-up of 5000 children given a single dose of live attenuated measles vaccine (schwarz strain) when aged 10 months to 2 years shows a high level of protection in comparison with an unvaccinated group. this protection has been maintained for 12 years. measles in vaccinated children was less severe as well as less frequent throughout the period. there is no evidence from the follow-up so far that a further injection of vaccine is needed; this has been confirmed by measles haemagglutination-inh ...197771396
live measles vaccine: a 21 year follow up.21 years after receiving schwartz strain live measles vaccine 4500 trial participants showed a continuing high level of protection compared with those who were unvaccinated. over the last seven years of the follow up no cases of measles were reported in vaccinated participants who had had close contact with the disease. immunity induced by the vaccine seems to survive the challenge of close contact with measles in young children, even after 21 years.19873113599
predicting the impact of measles vaccination in england and wales: model validation and analysis of policy options.measles incidence in england and wales has fallen to an all-time low. attention is now focused on preventing local outbreaks, and, in the long run, on the elimination of indigenous measles. a realistic age-structured (ras) mathematical model of measles transmission is used to reconstruct the impact of measles vaccination in england and wales from 1968 to the present and to evaluate the merits of future policy options. in general, the predictions of the model show good agreement with long-term ag ...19957705494
towards eradication of measles virus: global progress and strategy evaluation.despite an increase in global measles vaccine coverage from under 20% in 1980 to around 80% in 1990, measles remains a major cause of morbidity and mortality world-wide. this paper addresses a number of issues relating to efforts to control measles, namely, (i) at the global level, how might we assess the impact of measles vaccination on the incidence of infection and associated disease, and, (ii), at the strategic level, how can we utilise an understanding of the transmission dynamics of childh ...19958588328
ten years of serological surveillance in england and wales: methods, results, implications and action.the first age-stratified serological survey of antibody to measles, mumps and rubella in the uk was conducted in 1986/87 prior to the introduction of mmr vaccine into the immunization programme. serum collection and testing have continued annually, allowing trends over time to be monitored. these sera have also been available for ad hoc surveys of other infections.200010817137
the elimination of indigenous measles transmission in england and wales.following a school-based measles-rubella vaccination campaign in november 1994, enhanced surveillance of measles, including igm antibody testing of oral fluid from clinically diagnosed case-patients, was introduced in england and wales. between 1995 and 2001, 665 cases of measles were confirmed, including 371 (56%) confirmed only by igm detection in oral fluid. two hundred thirty-nine cases (36%) were sporadic and 426 (64%) were associated with 61 clusters. fifty-four (23%) of the 239 sporadic c ...200312721914
the epidemiology of subacute sclerosing panencephalitis in england and wales 1990-2002.to assess the impact of measles/mumps/rubella (mmr) vaccine on the epidemiology of subacute sclerosing panencephalitis (sspe) in england and wales.200415557053
interpreting serological surveys using mixture models: the seroepidemiology of measles, mumps and rubella in england and wales at the beginning of the 21st century.a mixture modelling technique is applied to age-specific frequency distributions of quantitative results from serological surveys for measles, mumps and rubella using samples collected across the age range in england and wales in 2000. in accordance with previous studies the analysis suggests that the antibody response to natural infection is stronger than that produced by vaccination, that vaccine-induced antibody levels wane with time and that levels of vaccine-induced antibody response vary f ...200616650326
protecting infants against measles in england and wales: a review.to establish the most appropriate age ranges for the use of human normal immunoglobulin and mmr vaccine as postexposure prophylaxis.200919457878
self-collected buccal swabs and rapid, real-time pcr during a large measles outbreak in wales: evidence for the protective effect of prior mmr immunisation.we describe the laboratory response to a large measles outbreak that occurred during 2012-2013 centred in mid and west wales, uk.201525959148
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