Publications

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an outbreak of infection with shigella flexneri 1b in south east england. 19989737062
ongoing outbreak of shigella flexneri serotype 3a in men who have sex with men in england and wales, data from 2009-2011.diagnoses of shigella flexneri in the united kingdom (uk) are usually travel-related. however, since 2009, there has been an overall increase in uk-acquired cases. the health protection agency has been investigating a national outbreak of s. flexneri detected in 2011 and which is still ongoing. cases occurred mostly in men who have sex with men and were of serotype 3a. the investigation aimed at obtaining epidemiological data to inform targeted outbreak management and control.201222490381
increasing incidence of antibiotic resistance in shigellas from humans in england and wales: recommendations for therapy.since 1983 the incidence of resistance to ampicillin in shigella dysenteriae, sh. flexneri, and sh. boydii infections in england and wales has increased from 42% to 65% and the incidence of resistance to trimethoprim, from 6% to 64%. furthermore, of 1524 strains received in 1995-1996, 46% were resistant to both of these antimicrobials. for sh. sonnei almost 50% of isolates were resistant to ampicillin or trimethoprim and 15% were resistant to both of these antimicrobials. these results demonstra ...19989533726
drug resistance in shigella dysenteriae, s flexneri and s boydii in england and wales: increasing incidence of resistance to trimethoprim.a total of 2753 strains of shigella belonging to subgroups a, b, and c that were isolated from patients in england and wales during the period from 1979 to mid-1983 were studied. of these, 1690 (61%) were from patients recently returned from abroad or in contact with recent travellers, and 760 (45%) of these affected travellers from the indian subcontinent. the number of strains resistant to sulphonamides and streptomycin remained at a high level throughout (average 76% and 72% respectively). re ...19846423079
plasmid-determined antibiotic resistance in shigella flexneri isolated in england and wales between 1974 and 1978.the majority of shigella flexneri strains isolated in england and wales are from infections contracted abroad. most of these strains are drug-resistant, over 75% being resistant to streptomycin and sulphonamides, sulphonamides alone or streptomycin, sulphonamides and tetracyclines. a selection of resistant strains was tested for resistance transfer and the plasmids identified were characterized by compatibility grouping. streptomycin and sulphonamide resistance was usually determined by a non-au ...19836337209
shigella dysenteriae, sh flexneri, and sh boydii infections in england and wales: the importance of foreign travel. 1979389342
sex, drugs and smart phone applications: findings from semistructured interviews with men who have sex with men diagnosed with shigella flexneri 3a in england and wales.to inform control strategies undertaken as part of an outbreak of shigella flexneri 3a among men who have sex with men (msm).201525921020
intensified shigellosis epidemic associated with sexual transmission in men who have sex with men--shigella flexneri and s. sonnei in england, 2004 to end of february 2015.surveillance data suggest an intensification of the shigellosis epidemic associated with sexual transmissionin men who have sex with men (msm) in england with separate introductions into the population. in 2014, sexual transmission between msm might have accounted for 97%, 89%, and 43% of non-travel associated shigella flexneri 3a and s. flexneri 2a, ands. sonnei diagnoses. clinicians should sensitively ascertain sexual history for men with enteric infections to facilitate prompt diagnosis and a ...201525953129
identification of escherichia coli and shigella species from whole-genome sequences.escherichia coli and shigella species are closely related and genetically constitute the same species. differentiating between these two pathogens and accurately identifying the four species of shigella are therefore challenging. the organism-specific bioinformatics whole-genome sequencing (wgs) typing pipelines at public health england are dependent on the initial identification of the bacterial species by use of a kmer-based approach. of the 1,982 escherichia coli and shigella sp. isolates ana ...201727974538
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