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antibody-based diagnostic for 'refractory' periodontitis.about 10-15% of us adults are 'refractory' to therapy for chronic periodontitis. recently, studies suggest that these patients have elevated lysine decarboxylase activity in the sulcular microbiota. the aim of this study was to determine whether an elevated igg antibody response to lysine decarboxylase, alone or with antibody to other bacterial antigens and baseline clinical measurements, would predict 'refractory' patients with high accuracy.200212445226
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