Publications

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occurrence of haemophilus epiglottitis. 1978306191
haemophilus influenzae infections. 19724536609
pulmonary infiltrates in the surgical icu: prospective assessment of predictors of etiology and mortality.a prospective cohort study of 129 consecutive patients developing pulmonary infiltrates in the surgical icu was conducted to determine the predictors and outcome of pulmonary infiltrates. most common etiologies of pulmonary infiltrates were pneumonia (30%), pulmonary edema (29%), acute lung injury (15%), and atelectasis (13%). enteral nutrition was associated with a significantly lower incidence of acute lung injury as compared with pneumonia (22% vs 58%, p = 0.012). patients with liver disease ...19989792588
haemophilus influenzae type b disease among amish children in pennsylvania: reasons for persistent disease.to identify reservoirs of haemophilus influenzae type b (hib) pharyngeal carriage and assess barriers to vaccination among 2 amish communities in pennsylvania.200111581468
bacterial meningitis in childhood at the children's hospital of pittsburgh: 1988-1998.bacterial meningitis is an important acute infectious disease of childhood that remains a source of substantial morbidity and mortality. the impact of the haemophilus influenzae type b (hib) conjugate vaccines on the epidemiology of the other bacterial causes of meningitis in childhood has received little attention. the objective of this study is to report the experience at a tertiary-care children's hospital with the occurrence of bacterial meningitis before and after the licensure of the hib c ...200111758958
an outbreak of haemophilus influenzae type b bacteraemia in an intermediate care hospital for children.an outbreak of haemophilus influenzae type b bacteraemia in the infant unit of a paediatric intermediate care hospital is described. a high attack rate of 36% (four of 11 patients) was found, which was of concern in a population already compromised by chronic illness. the use of rifampicin for all patients in the unit, and staff coming into contact with them, as well as general infection control measures, brought the outbreak to an abrupt halt. the place of rifampicin prophylaxis for hospital co ...19882896679
ten-year review of otitis media pathogens.data collected from 1980 to 1989 by investigators at the pittsburgh otitis media research center were examined to detect changes over time in the prevalence of bacteria isolated from middle ear effusions in patients with otitis media. the organisms isolated most commonly from the 7396 effusions cultured at the center were streptococcus pneumoniae and haemophilus influenzae. s. pneumoniae predominated in the subgroup of patients with acute otitis media, whereas h. influenzae was isolated most fre ...19921513611
a changing pattern of epiglottitis.a case review of epiglottitis at geisinger medical center over the past 12 years demonstrates a decrease in the number of pediatric patients with epiglottitis and an increase in the number of adults with epiglottitis. in the last five years, the number of epiglottitis patients younger than 10 years has fallen (0 cases), while the number of patients over 10 years of age has increased (6 cases). the cause of epiglottitis, hemophilus influenzae type b, remains constant in the pediatric as well as i ...19921468169
invasive haemophilus influenzae type b disease in five young children--minnesota, 2008.in 2008, five children aged <5 years were reported to the minnesota department of health (mdh) with invasive haemophilus influenzae type b (hib) disease; one died. only one of the children had completed the primary hib immunization series; three had received no doses of hib-containing vaccine. the five hib cases are the largest number among children aged <5 years reported from minnesota since 1992. the cases occurred during a hib vaccine recall and continuing nationwide shortage that began in de ...200919177041
continued shortage of haemophilus influenzae type b (hib) conjugate vaccines and potential implications for hib surveillance--united states, 2008.in december 2007, merck & co., inc. (west point, pennsylvania) announced a voluntary recall of certain lots of two haemophilus influenzae type b (hib) conjugate vaccines, pedvaxhib (monovalent hib vaccine) and comvax (hib-hepb vaccine) and suspended production of both vaccines, disrupting the u.s. supply of hib vaccine. when the recall was announced, merck projected restoration of these vaccines to the u.s. market in late 2008. to ensure that enough vaccine would be available for all u.s. childr ...200819023262
licensure of a diphtheria and tetanus toxoids and acellular pertussis adsorbed, inactivated poliovirus, and haemophilus b conjugate vaccine and guidance for use in infants and children.on june 20, 2008 the food and drug administration (fda) licensed a combined diphtheria and tetanus toxoids and acellular pertussis adsorbed (dtap), inactivated poliovirus vaccine (ipv), and haemophilus influenzae type b conjugate (tetanus toxoid [tt] conjugate) vaccine, dtap-ipv/hib (pentacel, sanofi pasteur, swiftwater, pennsylvania), for use as a four-dose series in infants and children at ages 2, 4, 6, and 15-18 months. this report summarizes the indications for pentacel and provides guidance ...200818830213
feasibility of influenza immunization for inner-city children aged 6 to 23 months.annual influenza-related hospitalization rates of children aged < 2 years in the united states are second only to those of the elderly. yet no recommendations existed for vaccinating healthy children aged 6 to 23 months until 2002, when the advisory committee on immunization practices encouraged influenza vaccination for them. this study tested the feasibility of vaccinating 6- to 23-month-old children against influenza and assessed the effect on timely receipt of other vaccines.200415556740
children who have received no vaccines: who are they and where do they live?each year 2.1 million children 19 to 35 months of age are undervaccinated. among these are children who have received no vaccinations. unvaccinated children are at increased risk of acquiring and transmitting vaccine-preventable diseases.200415231927
do laws bring children in child care centers up to date for immunizations?pennsylvania state law requires licensed child care centers (cccs) to document that each enrolled child is up to date (utd) for routine immunizations within 60 days of enrollment. this study evaluates the law's impact on immunization coverage among children aged <or=59 months who attend cccs in philadelphia.200312708893
update: expanded availability of thimerosal preservative-free hepatitis b vaccine.thimerosal, a mercury-based compound, is no longer used as a preservative in any of the pediatric hepatitis b vaccines licensed in the united states. on march 28, 2000, smithkline beecham biologicals (rixensart, belgium) received approval from the food and drug administration of a supplement to its hepatitis b license to include the manufacture of single-antigen, preservative-free hepatitis b vaccine (engerix-b, pediatric/adolescent); distribution of this product has begun. a single-antigen, pre ...200010926308
increasing immunization: a medicaid managed care model.to evaluate the impact of an immunization outreach program on immunization rates.19979096172
immunization status of children on school entry: area analysis and recommendations 1991.the objective of the study was to examine the immunization status of children entering school as of september 1990 in two selected school districts in the pittsburgh area. immunization levels were determined by review of the students' school health/immunization records using aap recommendations for age-appropriate vaccines for these children at the onset of the study. a telephone survey of parents was then conducted. reasons for lack of adequate immunizations and demographic data were examined i ...19968804541
a decline in haemophilus influenzae type b meningitis. 19938441095
epiglottitis in children, 1979 through 1992. effects of haemophilus influenzae type b immunization.to examine secular trends in the epidemiology, bacteriology, and clinical presentation of acute epiglottitis in children in the years surrounding the introduction of vaccine against haemophilus influenzae type b.19948143009
meningitis. update of recommendations for the neonate.our series of children with meningitis shows an increase in the frequency of isolation of hemophilus influenzae type b. this increase is most marked among children between one and two months of age. since h. influenzae was found in five of the seven children between thirty and sixty days of age, we recommend the use of chloramphenicol for the initial treatment of bacterial meningitis after the first month of life. additionally, our mortality data suggest that early diagnosis and intensive suppor ...19806989544
increase in influenzal meningitis. 19715314956
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