| lipoxazolidinones a, b, and c: antibacterial 4-oxazolidinones from a marine actinomycete isolated from a guam marine sediment. | marine actinomycete strain nps008920, a member of the new genus marinispora, was isolated from a sediment sample collected in cocos lagoon, guam. in natural sea water containing media, the strain produced a series of novel 2-alkylidene-5-alkyl-4-oxazolidinones, lipoxazolidinone a (1), b (2), and c (3). compounds 1- 3 showed broad spectrum antimicrobial activity similar to that of the commercial antibiotic linezolid (zyvox), a 2-oxazolidinone. hydrolysis of the amide bond of the 4-oxazolidinone r ... | 2007 | 17845000 |