failure of the mycobacterium bovis bcg vaccine: some species of environmental mycobacteria block multiplication of bcg and induction of protective immunity to tuberculosis.the efficacy of mycobacterium bovis bacillus calmette-guérin (bcg) vaccine against pulmonary tuberculosis (tb) varies enormously in different populations. the prevailing hypothesis attributes this variation to interactions between the vaccine and mycobacteria common in the environment, but the precise mechanism has so far not been clarified. our study demonstrates that prior exposure to live environmental mycobacteria can result in a broad immune response that is recalled rapidly after bcg vacci ...200211796598
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