Publications

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preliminary observations on the uptake poliovirus by west coast shore crabs.west coast shore crabs (pachygrapsus sp. and hemigrapsus sp.), when in seawater contaminated with poliovirus or allowed to feed on virus-contaminated mussels (mytilus californianus), were found to accumulate high titers of virus.19724333894
procedure for recovery of enteroviruses from the japanese cockle tapes japonica.the most likely shellfish to be harvested if sportfishing is reinstated in san francisco bay is the japanese cockle tapes japonica. the virus levels present in these shellfish are unknown and need to be evaluated before the shellfish beds are open. towards this end, a procedure for recovering and concentrating enteric viruses from these clams has been evaluated. effective elution of poliovirus from clam tissues was found to occur with ph 9.5 glycine-buffered saline rather than with the ph 7.5 fl ...19816263186
human virus and bacteriophage inactivation in clear water by simulated sunlight compared to bacteriophage inactivation at a southern california beach.few quantitative data exist on human virus inactivation by sunlight and the relationship between human and indicator viruses under sunlit conditions. we investigated the effects of sunlight on human viruses (adenovirus type 2, poliovirus type 3) and bacteriophages (ms2, q-beta sp, fi, m13, prd1, phi-x174, and coliphages isolated from avalon bay, california). viruses were inoculated into phosphate buffered saline or seawater, exposed to a laboratory solar simulator for ≤12 h, and enumerated by do ...201020726507
acute flaccid paralysis with anterior myelitis - california, june 2012-june 2014.in august 2012, the california department of public health (cdph) was contacted by a san francisco bay area clinician who requested poliovirus testing for an unvaccinated man aged 29 years with acute flaccid paralysis (afp) associated with anterior myelitis (i.e., evidence of inflammation of the spinal cord involving the grey matter including anterior horn cell bodies) and no history of international travel during the month before symptom onset. within 2 weeks, cdph had received reports of two a ...201425299608
acute flaccid myelitis of unknown etiology in california, 2012-2015.there has been limited surveillance for acute flaccid paralysis in north america since the regional eradication of poliovirus. in 2012, the california department of public health received several reports of acute flaccid paralysis cases of unknown etiology.201626720027
virology, epidemiology, pathogenesis, and control of enterovirus 71.first isolated in california, usa, in 1969, enterovirus 71 (ev71) is a major public health issue across the asia-pacific region and beyond. the virus, which is closely related to polioviruses, mostly affects children and causes hand, foot, and mouth disease with neurological and systemic complications. specific receptors for this virus are found on white blood cells, cells in the respiratory and gastrointestinal tract, and dendritic cells. being an rna virus, ev71 lacks a proofreading mechanism ...201020961813
immunization coverage among predominantly hispanic children, aged 2-3 years, in central los angeles.to assess the immunization status of young children in a predominantly hispanic region in and around downtown los angeles, and factors associated with complete immunization by age 24 months.200010813509
molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998.enterovirus 71 (ev71) (genus enterovirus, family picornaviridae), a common cause of hand, foot, and mouth disease (hfmd), may also cause severe neurological diseases, such as encephalitis and poliomyelitis-like paralysis. to examine the genetic diversity and rate of evolution of ev71, we have determined and analyzed complete vp1 sequences (891 nucleotides) for 113 ev71 strains isolated in the united states and five other countries from 1970 to 1998. nucleotide sequence comparisons demonstrated t ...199910559310
a method to detect low levels of enteric viruses in contaminated oysters.direct isolation and identification of pathogenic viruses from oysters implicated in gastroenteritis outbreaks are hampered by inefficient methods for recovering viruses, naturally occurring pcr inhibitors, and low levels of virus contamination. in this study we focused on developing rapid and efficient oyster-processing procedures that can be used for sensitive pcr detection of viruses in raw oysters. poliovirus type 3 (pv3) sabin strain was used to evaluate the efficacy of virus recovery and t ...199910543775
safety of sabin oral poliovaccine strains; mass immunization program in los angeles county, 1962-1963. 196314061062
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