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attrition of bystander cd8 t cells during virus-induced t-cell and interferon responses.experiments designed to distinguish virus-specific from non-virus-specific t cells showed that bystander t cells underwent apoptosis and substantial attrition in the wake of a strong t-cell response. memory cd8 t cells (cd8(+) cd44(hi)) were most affected. during acute viral infection, transgenic t cells that were clearly defined as non-virus specific decreased in number and showed an increase in apoptosis. also, use of lymphocytic choriomeningitis virus (lcmv) carrier mice, which lack lcmv-spec ...200111390598
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