specific restrictions in the progression of venezuelan equine encephalitis virus-induced disease resulting from single amino acid changes in the glycoproteins.the pathogenesis of venezuelan equine encephalitis virus (vee) was examined in the mouse model using v3000, a virus derived from a molecular clone of the trinidad donkey strain of vee. these results were compared in parallel experiments with avirulent mutants of vee derived by site-directed mutagenesis of the clone. adult mice, inoculated subcutaneously in their left rear footpad with v3000, were followed in a time course study for 6 days in which 15 organs were tested for histopathological chan ...19957856110
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