| functional variants in nos1 and nos2a are not associated with progressive hearing loss in ménière's disease in a european caucasian population. | hearing loss in ménière's disease (md) is associated with loss of spiral ganglion neurons and hair cells. in a guinea pig model of endolymphatic hydrops, nitric oxide synthases (nos) and oxidative stress mediate loss of spiral ganglion neurons. to test the hypothesis that functional variants of nos1 and nos2a are associated with md, we genotyped three functional variants of nos1 (rs41279104, rs2682826, and a cytosine-adenosine microsatellite repeat in exon 1f) and the ccttt repeat in the promote ... | 2011 | 21612410 |