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lipids of putative relevance to virulence in mycobacterium tuberculosis: phthiocerol dimycocerosate and the attenuation indicator lipid.lipid compositions of 40 patient isolates of mycobacterium tuberculosis derived from madras, burma, rangoon, and east africa were studied, and two major populations of tubercle bacilli were distinguished. nearly all of the strains previously designated as attenuated for the guinea pig (d. a. mitchison) are characterized by a specific phenolic phthiocerol diester which is identified with the aglycone moieties of mycosides a and b (and probably g). this lipid (ai) was not seen in any of the more v ...19744271720
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