| attenuated nycbh vaccinia virus deleted for the e3l gene confers partial protection against lethal monkeypox virus disease in cynomolgus macaques. | the new york city board of health (nycbh) vaccinia virus is the currently licensed vaccine for use in the us against smallpox. the vaccine under investigation in this study has been attenuated by deletion of the innate immune evasion gene, e3l, and shown to be protective in homologous virus mouse challenge and heterologous virus mouse and rabbit challenge models. in this study we compared nycbh deleted for the e3l gene (nycbhδe3l) to nycbh for the ability to induce phosphorylation of proinflamma ... | 2011 | 22001879 |