| viridamides a and b, lipodepsipeptides with antiprotozoal activity from the marine cyanobacterium oscillatoria nigro-viridis. | parallel chemical and phylogenetic investigation of a marine cyanobacterium from panama led to the isolation of two new pks-nrps-derived compounds, viridamides a and b. their structures were determined by nmr and mass spectroscopic methods, and the absolute configurations assigned by marfey's method and chiral hplc analysis. in addition to six standard, n-methylated amino and hydroxy acids, these metabolites contained the structurally novel 5-methoxydec-9-ynoic acid moiety and an unusual proline ... | 2008 | 18715036 |
| cytotoxic veraguamides, alkynyl bromide-containing cyclic depsipeptides from the marine cyanobacterium cf. oscillatoria margaritifera. | a family of cancer cell cytotoxic cyclodepsipeptides, veraguamides a-c (1-3) and h-l (4-8), were isolated from a collection of cf. oscillatoria margaritifera obtained from the coiba national park, panama, as part of the panama international cooperative biodiversity group program. the planar structure of veraguamide a (1) was deduced by 2d nmr spectroscopy and mass spectrometry, whereas the structures of 2-8 were mainly determined by a combination of (1)h nmr and ms(2)/ms(3) techniques. these new ... | 2011 | 21488639 |
| Cannabinomimetic lipid from a marine cyanobacterium. | NMR-guided fractionation of two independent collections of the marine cyanobacteria Lyngbya majuscula obtained from Papua New Guinea and Oscillatoria sp. collected in Panama led to the isolation of the new lipids serinolamide A (3) and propenediester (4). Their structures were determined by NMR and MS data analysis. Serinolamide A (3) exhibited a moderate agonist effect and selectivity for the CB1 cannabinoid receptor (Ki=1.3 µM, >5-fold) and represents the newest addition to the known cannabino ... | 2011 | 21999614 |