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clinical and serologic study of four smallpox vaccines comparing variations of dose and route of administration. basic study and laboratory standardization.the present four-center collaborative study was undertaken in an attempt to define the best vaccine and/or vaccination procedure for use in areas of the world that are free of smallpox. the study was designed to compare the effect of different vaccinial strains, viral concentrations, and routes of administration on the morbidity and antibody response associated with primary vaccination and standard challenge revaccination. primary vaccinations were performed on 1,585 children; 49.6% of the child ...1977188950
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