| tlr3 is essential for the induction of protective immunity against punta toro virus infection by the double-stranded rna (dsrna), poly(i:c12u), but not poly(i:c): differential recognition of synthetic dsrna molecules. | in the wake of rna virus infections, dsrna intermediates are often generated. these viral pathogen-associated molecular patterns can be sensed by a growing number of host cell cytosolic proteins and tlr3, which contribute to the induction of antiviral defenses. recent evidence indicates that melanoma differentiation-associated gene-5 is the prominent host component mediating ifn production after exposure to the dsrna analog, poly(i:c). we have previously reported that punta toro virus (ptv) infe ... | 2007 | 17404303 |