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[circulation of a different lineage of dengue virus serotype 2 american / asian genotype in the peruvian amazon, 2010.]our objective was to determine the genotype of the dengue virus type 2 (denv-2) that circulated in the amazon region of peru between november 2010 and january 2011. we analyzed eight samples collected during dengue surveillance activities in the cities of iquitos, yurimaguas, trujillo, tarapoto and lima between november 2010 and january 2011 that were sent to insitituto nacional de salud. the viruses were isolated in c6/36 ht cell line. viral rna was extracted and the serotype (rt - pcr multiple ...201121537772
lineage ii of southeast asian/american denv-2 is associated with a severe dengue outbreak in the peruvian amazon.during 2010 and 2011, the loreto region of peru experienced a dengue outbreak of unprecedented magnitude and severity for the region. this outbreak coincided with the reappearance of dengue virus-2 (denv-2) in loreto after almost 8 years. whole-genome sequence indicated that denv-2 from the outbreak belonged to lineage ii of the southeast asian/american genotype and was most closely related to viruses circulating in brazil during 2007 and 2008, whereas denv-2 previously circulating in loreto gro ...201425002298
effect of dengue-1 antibodies on american dengue-2 viral infection and dengue haemorrhagic fever.in iquitos, peru, no cases of dengue haemorrhagic fever have been recorded in individuals infected with dengue-1 virus followed by american genotype dengue-2 (american dengue-2) virus. we assayed serum samples collected in iquitos that tested positive for antibodies of monotype dengue-1 and monotype dengue-2 using a plaque reduction neutralisation test to determine their ability to neutralise the infectivity of two dengue-1 viruses, two american dengue-2 viruses, and two asian dengue-2 viruses. ...200212147378
failure of secondary infection with american genotype dengue 2 to cause dengue haemorrhagic fever.population-based epidemiological studies have shown that infection with dengue type 2 (den-2) virus in individuals previously infected with a different serotype of the virus is a major risk factor for dengue haemorrhagic fever and dengue shock syndrome. however, the western hemisphere was spared epidemics of these two syndromes, until the introduction of a southeast asian den-2 genotype. possibly american den-2 genotype strains lacked properties necessary to cause severe disease. we report on a ...199910543670
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