acquired aplastic anemia: correlation between etiology, pathophysiology, bone marrow histology and prognosis factors. | aplastic anemia is a clonal disease of stem cell characterized by peripheral blood pancytopenia with hypocellular bone marrow. in most cases acquired aplastic anemia is an autoimmune, t-cell mediated disease (hematopoiesis is mediated by a population of cd8+ t-cells which produce inhibitory cytokines - tnf-alpha, ifn-gamma, il-6 which suppress hematopoiesis by affecting the mitotic cycle and cell killing by inducing apoptosis). in some cases radiation, medical drugs and chemicals, viruses induce ... | 2009 | 19942964 |