| [creutzfeldt-jakob disease in france: an epidemiological update (author's transl)]. | we report here the results of a prospective epidemiological study of creutzfeldt-jakob disease in continental france during the years 1978-80, extending a retrospective study of the decade 1968-1977 previously reported. the new annual mortality figures are 0.53 cases per million people for france as a whole, and 1,01 cases per million people for the paris metropolitan area. the correlation between mortality rate and population density persists in the parisian area, and is not related to differen ... | 1982 | 7048483 |
| epidemiologic comparisons between creutzfeldt-jakob disease and scrapie in france during the 12-year period 1968-1979. | systematic investigation of the occurrence of scrapie in france revealed that between 1968 and 1979 the disease has been diagnosed in a total of 145 flocks, in virtually every region where sheep are raised. the geographic distribution of scrapie-affected flocks was unrelated to the residential location of patients dying of creutzfeldt-jakob disease (cjd) during this period, arguing against direct contact or indirect vector transmission of the disease to humans. regional lamb consumption was not ... | 1981 | 7024478 |
| study of endemic scrapie in a flock of "ile de france" sheep. | an "ile de france" flock was studied over a period of 5 years. the authors found similar results concerning incidence and age of onset of scrapie to those found in the english literature. a close relationship was established between the age of the dam at parturition and the age of the progeny at onset of scrapie. in the later years of our study, scrapie was detected in younger animals than in the earlier years, suggesting a phenomenon of genetic "anticipation". increased fecundity in this endemi ... | 1986 | 3770148 |
| the epidemiology of creutzfeldt-jakob disease: conclusion of a 15-year investigation in france and review of the world literature. | during the 15-year period 1968-1982, a total of 329 patients dying of creutzfeldt-jakob disease (cjd) were identified in continental france. annual mortality rates stabilized at 0.5 to 0.6 cases per million (1.1 to 1.2 cases per million in paris). six percent of cases were familial. although the frequency of cjd was related to population density, no contacts could be established among the great majority of patients. no association with socioeconomic factors, preceding trauma or surgery (exceptin ... | 1987 | 3295589 |
| [creutzfeldt-jacob disease in continental france. retrospective study from 1968 to 1977]. | during the decade 1968-1977, 170 cases of creutzfeldt-jakob disease were found in france. the clinical features of 124 neuropathologically-verified cases are summarized and a multi-factor analysis performed to obtain the most frequent combinations of signs and symptoms. certain exceptional features are discussed. the annual mortality rate during this period was 0.32 cases per million for the whole of france, and 0.69 cases per million for the paris metropolitan area. preliminary totals for 1978 ... | 1979 | 395612 |
| creutzfeldt-jakob disease in france: iii. epidemiological study of 170 patients dying during the decade 1968--1977. | systematic search for creutzfeldt-jakob disease (cjd) in france yielded a total of 170 patients dying between 1968 and 1977. the overall annual mortality rate from cjd for france was 0.32 case per million persons, with by far the highest rate (1.33 cases per million) in the most densely populated parts of paris. a highly significant correlation between population density and the mortality rate of cjd in the paris urban agglomeration was consistent with the hypothesis of human-to human disease tr ... | 1979 | 391142 |