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survey of natural scrapie in japan: analysis of rflp types of the prp gene and detection of prpsc mainly in suffolk sheep.we examined the brains, spleens and/or lymph nodes of 197 mainly suffolk sheep collected from hokkaido, and the tohoku, kanto and chubu districts to detect prpsc and thus to estimate scrapie contamination in japan. sixteen sheep in hokkaido and 2 sheep in other districts that were introduced from hokkaido were positive for prpsc. by comparison of the frequencies of the restriction fragment length polymorphism (rflp) types of these 18 scrapie sheep with 128 healthy sheep, we confirmed the associa ...19947999881
japanese scrapie cases.worldwide attention has been given to scrapie, because bovine spongiform encephalopathy (bse) could be experimentally transmitted to sheep. this ovine form of bse was clinically identical to scrapie. in japanese scrapie cases, a majority of the diseased sheep were from suffolk, while 8 cases were from corriedale. it is very likely that sheep-to-sheep transmission of scrapie has taken place in obihiro, hokkaido. normal prion protein may play a role in the morphoregulatory signaling pathway, which ...200010871915
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