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an increase in multi-drug-resistant isolates of salmonella typhimurium from healty carriers in aichi, japan.to investigate the prevalence of drug-resistant isolates of salmonella typhimurium in aichi, japan, we performed antimicrobial susceptibility tests for 148 isolates from healthy carriers, and from sporadic and outbreak cases of salmonellosis from 1980 to 1999. we found an increase in drug-resistant isolates from 56% (37/66) in the 1980s to 74% (61/82) in the 1990s due to increasing examples of four-, five-, and six-drug resistances. of 98 resistant isolates in 1980-1999, 12 were identified as am ...200011056559
[serovars and drug susceptibility of salmonella isolated in humans from 1987-1993 in aichi prefecture].drug susceptibility and serovars for a total of 1,110 strains of salmonella isolated from humans during a period from 1987-1993 in aichi prefecture were studied. the isolates consists of 1,022 strains from healthy individuals and patients with sporadic diarrhea, 36 imported strains from overseas travellers, and 52 strains from patients involved in 7 food poisoning incidents. the strains of the first group were serologically classified into 93 serovars. the predominant serovars isolated were s. e ...19969017920
molecular epidemiology of salmonella enteritidis. an outbreak and sporadic cases studied by means of pulsed-field gel electrophoresis.large outbreaks of diarrhoea due to salmonella enteritidis in aichi-ken, japan, provided the opportunity to investigate aspects of the molecular epidemiology of this and related organisms. this was performed by comparing the plasmid profile types, phage types, antimicrobial resistance, and the restriction fragment length polymorphisms (rflps) by pulsed-field gel electrophoresis (pfge) of s. enteritidis from outbreaks and sporadic cases. among the isolates studied, 10 distinctive rflp types were ...19958586841
isolation and identification of non-chlorinated phenylbenzotriazole (non-clpbta)-type mutagens in the ho river in shizuoka prefecture, japan.we previously identified 2-[2-(acetylamino)-4-amino-5-methoxyphenyl]-5-amino-7-bromo-4-chloro-2h-benzotriazole (pbta) congeners as major mutagens in water concentrates from several rivers that flow in three different areas, i.e. kyoto, aichi, and fukui prefectures, in japan. in synthesis studies, these pbtas were shown to be formed from corresponding dinitrophenylazo dyes via non-chlorinated derivatives (non-clpbtas). however, only non-clpbta-1, i.e. 2-[2-(acetylamino)-4-[bis(2-methoxyethyl)amin ...200616962368
detection of a novel mutagen, 3,6-dinitrobenzo[e]pyrene, as a major contaminant in surface soil in osaka and aichi prefectures, japan.we previously identified 1,3-, 1,6-, and 1,8-dinitropyrene (dnp) isomers as major mutagens in surface soil in three metropolitan areas of japan. in the present study, an organic extract from surface soil collected at a park in takatsuki in osaka prefecture, which showed extremely high mutagenicity in salmonella typhimurium ta98 in the absence of mammalian metabolic system (s9 mix), was investigated to identify major mutagens. a new powerful bacterial mutagen, as well as 1,6- and 1,8-dnp isomers, ...200515720134
a new clonal line of salmonella saintpaul having emerged and prevailed since 1999 in aichi, japan. 200312824694
synthesis of 2-phenylbenzotriazole-type mutagens, pbta-5 and pbta-6, and their detection in river water from japan.we previously determined the chemical structures of four 2-phenylbenzotriazole mutagens (pbta-1, -2, -3 and -4) in blue rayon-adsorbed material from the nishitakase river in kyoto prefecture and the nikko river in aichi prefecture in japan. on the basis of a synthesis study, these four pbta derivatives were deduced to have originated from corresponding dinitrophenylazo dyes by reduction and chlorination. 2-[(2-bromo-4,6-dinitrophenyl)azo]-5-[bis(2-acetoxyethyl) amino]-4-methoxyacetanilide (color ...200111673076
isolation and identification of a new 2-phenylbenzotriazole-type mutagen (pbta-3) in the nikko river in aichi, japan.we have previously determined the chemical structures of two 2-phenylbenzotriazole mutagens (pbta-1 and pbta-2) in blue cotton-adsorbed material from the nishitakase river in kyoto, japan. in the present study, further analysis of mutagenic substances in the nikko river, which flows through aichi prefecture in japan, allowed the isolation of a new mutagen. material (2.2 g) adsorbed on blue cotton (3 kg) at a site below the sewage plant on the nikko river was purified by various column chromatogr ...200010898584
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