| pitiprolamide, a proline-rich dolastatin 16 analogue from the marine cyanobacterium lyngbya majuscula from guam. | an unusual cyclic depsipeptide, pitiprolamide (1), was isolated from the marine cyanobacterium lyngbya majuscula collected at piti bomb holes, guam. the structure was deduced using nmr, ms, x-ray crystallography, and enantioselective hplc-ms techniques. remarkably, proline represents half of the residues forming pitiprolamide (1). other distinctive features include a 4-phenylvaline (dolaphenvaline, dpv) moiety initially found in dolastatin 16 and the rare 2,2-dimethyl-3-hydroxyhexanoic acid (dmh ... | 2010 | 21138309 |