| an outbreak of hepatitis a among south african patients with hemophilia: evidence implicating contaminated factor viii concentrate as the source. | we report an outbreak of hepatitis a in nine south african hemophiliacs treated exclusively with infusions of factor viii concentrate. the solvent/detergent (s/d) method (which does not inactivate nonenveloped viruses) was used for virus eradication. in three of six patients studied at a molecular level hepatitis a virus (hav) complementary dna (cdna) amplified from serum by reverse transcription-polymerase chain reaction (rt-pcr) was identical to hav cdna in 1 of 14 lots (no. 53) of factor viii ... | 1995 | 7590648 |