| epidemiology of an outbreak of leptospirosis in man and dog. | an outbreak of leptospirosis in man and dog occurred during the monsoon in madras city, india. 48 (50.5%) of the 95 human sera tested were positive for leptospirosis. of these, 32 showed the presence of agglutinin to serovar icterohaemorrhagiae. 20 (21.3%) of the 94 canine sera tested were positive for leptospirosis. of these, 10 had agglutinins to serovar icterohaemorrhagiae and 9 to serovar canicola. among murine reservoirs, 8 (25%) of 32 rat sera and 10 (41.6%) of 24 bandicoot sera were posit ... | 1992 | 1424559 |
| human leptospirosis: a recent study in madras, india. | | 1991 | 1887496 |
| role of bandicoots in human leptospirosis in madras city. an epidemiological approach. | | 1986 | 3610301 |
| evidence of leptospiral infections in human samples in madras city. | | 1987 | 3666852 |
| isolation of leptospires and demonstration of antibodies in human leptospirosis in madras, india. | among 25 clinically suspected cases of leptospirosis, organisms could be isolated from blood and urine of only 10 cases but demonstrated in 15 cases. antibody titres at a low level were observed to one or more leptospiral antigens in all 25 cases. nine of the repeated samples from 12 cases showed a four-fold rise in titre. the highest antibody titres were seen against autumnalis. the predominant clinical picture was of fever, myalgia, conjunctival suffusion and jaundice with renal involvement. | 1983 | 6636272 |
| serological evidence of leptospirosis in a human population following an outbreak of the disease in cattle. | a serological study of leptospirosis in a human population, mainly children of a village near madras city in tamilnadu state, india, was undertaken following an outbreak of the disease in cattle as evidenced by clinical symptoms and serology. 27 (68%) of the 40 animal sera tested were positive for leptospiral antibodies. though cross reactions were present, higher titres and a greater number of positive reactions were seen against autumnalis antigen. 35 (47%) of the 75 human sera gave positive a ... | 1983 | 6679368 |
| prevalence of leptospiral agglutinins among conservancy workers in madras city, india. | in a study of 584 corporation conservancy (sanitation) workers who lived mostly in slums, and who worked in four corporation circles of madras city, india, 192 (32.9%) were found to be positive for agglutinins to leptospira interrogans. seropositivity prevalence increased with age, but was similar in males and females except in the youngest age group, where males predominated. prevalence in the four study areas ranged between 17.8 and 40.5% (p < 0.01). among 152 sera in which one serogroup predo ... | 1993 | 8429573 |
| leptospirosis in madras--a clinical and serological study. | leptospirosis was confirmed by microscopic agglutination test (mat) and/or elisa in 57 patients admitted to the government general hospital, madras, india, during november and december of 1990 and 1991 with symptomatology suggestive of the disease. fifty (88%) of the 57 cases were males; the mean age of all the cases was 39.6 years (range 17-72). the main clinical features were: fever 100% jaundice 84%, myalgia 82%, acute renal failure 72% and conjunctival suffusion 58%. non-azotemic jaundice oc ... | 1995 | 8713215 |
| leptospiral antibodies in patients with recurrent ophthalmic involvement. | leptospiral antibodies could be demonstrated by microscopic agglutination test in 14 of 15 (93%) patients with acute panuveitis and retinal vasculitis in a preliminary study undertaken during the postmonsoon period at madurai in tamilnadu, india. the predominant serogroup was pomona followed by autumnalis, australis and javanica, the titres being between 1:160 and 1:10240. titres in the normal controls were 1:20 to 1:80 in 8 of 20 mostly to the endemic serogroup autumnalis. the involvement of le ... | 1996 | 8926031 |
| identification of leptospira species in the pathogenesis of uveitis and determination of clinical ocular characteristics in south india. | uveitis is considered a rare complication of leptospirosis. this report describes an epidemic of uveitis among patients with leptospirosis and provides data, using polymerase chain reaction (pcr) amplification of leptospira dna, that the pathogenesis is associated with anterior chamber spirochetes. forty-six uveitis patients, 49 uveitis controls, and 54 cataract controls were enrolled at aravind eye hospital (madurai, india). leptospiral dna was detected by pcr of aqueous humor; serum antibody t ... | 1998 | 9593018 |
| leptospirosis among rice mill workers of salem, south india. | leptospirosis is not commonly reported from the salem district in central tamil nadu in india. in october 2000, a rice mill worker, who had fever and jaundice, tested positive in leptospiral igm enzyme-linked immunosorbent assay (elisa). microbiological and serological investigations were performed on the patient, a sample population of the rice mill workers, and the animal and rodent populations living in the same premises. leptospira was isolated from the patient about 2 weeks after the onset ... | 2002 | 12501258 |
| an institutional outbreak of leptospirosis in chennai, south india. | the emergence of an outbreak of leptospirosis in a nurses' hostel in chennai presented a challenge to identify and control the source of the outbreak. sixty-nine residents and staff members were interviewed to assess exposure factors. blood samples from the acute and convalescent patients were tested with the microscopic agglutination test using the serovars prevalent in chennai. polymerase chain reaction (pcr) was conducted on serum and water samples. based on preliminary investigation, control ... | 2003 | 15239298 |
| field rats form a major infection source of leptospirosis in and around madurai, india. | to determine the seroprevalence of leptospires and to isolate leptospira spp. from field rats and bandicoots in and around madurai. | 2007 | 18097111 |
| occurrence of leptospirosis among suspected cases in chennai, tamil nadu. | to evaluate the serological profile of leptospirosis by microscopic agglutination test (mat) and dark field microscopy (dfm) and to determine the serovar prevalence rate among patients with pyrexia of unknown origin. | 2011 | 21393887 |
| cloning, expression, and homology modeling of groel protein from leptospira interrogans serovar autumnalis strain n2. | leptospirosis is an infectious bacterial disease caused by leptospira species. in this study, we cloned and sequenced the gene encoding the immunodominant protein groel from l. interrogans serovar autumnalis strain n2, which was isolated from the urine of a patient during an outbreak of leptospirosis in chennai, india. this groel gene encodes a protein of 60 kda with a high degree of homology (99% similarity) to those of other leptospiral serovars. recombinant groel was overexpressed in escheric ... | 2011 | 22196358 |