hb karlskoga or alpha 2 beta (2)21(b3) asp-->his: a new slow-moving variant found in sweden. | an abnormal variant comprising approximately 39% of total hemoglobin was found in a 48-year-old swedish woman. the variant was eluted from ion exchange high performance liquid chromatography (hplc) used for routine quantification of hb a1c at a position similar to hb s. amplification of beta-globin exons and nucleotide sequencing revealed heterozygosity for a gat-->cat mutation in codon 21, corresponding to the amino acid substitution asp-->his at position 21. this mutation was confirmed by amin ... | 1993 | 8330972 |