| rotavirus specific breast milk antibody in two populations and possible correlates of protection. | since rotavirus infection is common in caracas, venezuela and seasonal in rochester, new york usa, researchers analyzed at least 65 and 58 breast milk samples form women in caracas and rochester respectively to identify rotavirus specific antibodies. the mothers had earlier participated in rhesus rotavirus serotype 3 (rrv) vaccine trials. the plaque reduction neutralization assay revealed that 84.6% of breast milk samples from venezuela had detectable antibody to rrv compared to only 50% in th ... | 1991 | 1667067 |
| horizontal transmission of rhesus monkey rotavirus-based quadrivalent vaccine during a phase 3 clinical trial in caracas, venezuela. | during a phase 3 clinical trial of rhesus monkey rotavirus-based quadrivalent vaccine in venezuela, 2207 infants received 3 oral doses of vaccine (4 x 105 plaque-forming units/dose) or placebo at ages approximately 2, 3, and 4 months; 219 (14%) of 1537 stools obtained during 1550 diarrheal episodes in postvaccination surveillance were rotavirus-positive by enzyme-linked immunosorbent assay. with the use of various vp7 and vp4 primers for genotyping purposes, 213 of 219 rotavirus-positive stools ... | 2003 | 12599053 |
| reactogenicity and antigenicity of rhesus rotavirus vaccine (mmu-18006) in newborn infants in venezuela. | the reactogenicity and antigenicity of the rhesus rotavirus vaccine, strain mmu18006, developed at the laboratory of infectious diseases (national institute of allergy and infectious diseases, national institutes of health) were examined in a double blind, placebo-controlled study of 40 newborn infants in caracas, venezuela. the children were observed for the first few days after birth in the hospital nursery and by home visits for 10 days after vaccination to detect any adverse reactions. no re ... | 1988 | 2852792 |
| reactions to and antigenicity of two human-rhesus rotavirus reassortant vaccine candidates of serotypes 1 and 2 in venezuelan infants. | the reactions to and antigenicity of two human-rhesus rotavirus (rrv) reassortants (human rotavirus strain d x rrv and human rotavirus strain ds1 x rrv) with the vp7 neutralization specificity of a serotype 1 or serotype 2 rotavirus were evaluated in a placebo-controlled double-blind trial in 116 1- to 5-month-old infants in caracas, venezuela. the children were randomly divided into five groups to receive orally the following inocula: (i) 10(4) pfu of d x rrv reassortant; (ii) 10(4) pfu of ds1 ... | 1989 | 2541168 |
| prospective study of diarrheal diseases in venezuelan children to evaluate the efficacy of rhesus rotavirus vaccine. | the efficacy of a rhesus rotavirus vaccine (mmu 18006, serotype 3) against infantile diarrhea was evaluated by active home surveillance of a group of 320 children 1-10 months of age in caracas, venezuela. during a 1 year period following oral administration of vaccine or placebo under a double-masked code, over 600 diarrheal episodes were detected. etiologic studies revealed that heat-stable toxin (st) producing enterotoxigenic e. coli (etec) was the most common diarrheal agent detected (34%) fo ... | 1990 | 2160516 |