| subgenotypes of hepatitis b virus genotype c do not correlate with disease progression of chronic hepatitis b in taiwan. | hepatitis b virus (hbv) genotype c (hbv/c) has two subgenotypes: hbv/cs and ce. the prevalence and clinical implications of subgenotype cs and ce in taiwanese hbv carriers remain unknown. | 2007 | 17696938 |
| hepatitis b virus genotype b has an earlier emergence of lamivudine resistance than genotype c. | hepatitis b virus (hbv) genotype b and c seem not to affect the therapeutic response to lamivudine (3tc). whether a given genotype has an earlier emergence of 3tc resistance remains unclear. we thus conducted this study to elucidate the association of hbv genotype with the emergence of 3tc-resistant strains in taiwanese patients. | 2009 | 20032545 |
| associations between hepatitis b virus genotype and mutants and the risk of hepatocellular carcinoma. | the risk of hepatocellular carcinoma (hcc) increases with increasing level of hepatitis b virus (hbv) in serum (viral load). however, it is unclear whether genetic characteristics of hbv, including hbv genotype and specific genetic mutations, contribute to the risk of hcc. we examined the hcc risk associated with hbv genotypes and common variants in the precore and basal core promoter (bcp) regions. | 2008 | 18695135 |
| long-term tracking of hepatitis b viral load and the relationship with risk for hepatocellular carcinoma in men. | little is known about the longitudinal course of hepatitis b virus (hbv) load and its relationship with the development of hepatocellular carcinoma (hcc). we conducted a case-cohort study nested within a cohort of 2874 hbv surface antigen-positive male taiwanese government employees aged 30 years or older. hbv genotype and dna levels (i.e. viral load) were tested using polymerase chain reaction-based assays on plasma samples from 112 cases and 1031 non-cases. prediagnostic plasma levels of hbv d ... | 2008 | 17999990 |
| clinical significance of hepatitis b virus (hbv) genotypes and precore and core promoter mutations affecting hbv e antigen expression in taiwan. | to assess the prevalence and clinical significance of hepatitis b virus (hbv) genotypes and precore and core promoter mutations in taiwan, a cohort of 200 taiwanese chronic hepatitis b patients was analyzed. the hbv genotypes and sequences of the precore and the core promoter regions were determined in 66 asymptomatic carriers and 134 patients who had liver biopsy-verified chronic hepatitis and liver cirrhosis. the hbv e-antigen (hbeag)-negative patients had a higher frequency of mutations at co ... | 2005 | 16333089 |
| genotypic dominance and novel recombinations in hbv genotype b and c co-infected intravenous drug users. | pathogenic differences among hepatitis b virus (hbv) genotypes have been documented. however, the interaction between different hbv genotypes remains unclear. herein, we chose hbv genotypes b (hbv/b) and c (hbv/c) co-infected intravenous drug users to study this issue. hbv genotype was determined in 40 hbsag, anti-hcv, and anti-hdv co-positive intravenous drug users by using genotype-specific primers. the distribution of hbv genotype was as follows: hbv genotype b alone in 29 (72.5%); hbv genoty ... | 2004 | 15042642 |
| hepatitis b genotypes correlate with tumor recurrence after curative resection of hepatocellular carcinoma. | hepatitis b virus (hbv) genotype c is associated with the development of hepatocellular carcinoma (hcc), compared with genotype b. this study aims to investigate whether hbv genotypes influence the clinicopathologic features and long-term prognosis of patients after curative resection of hcc. | 2004 | 15017634 |
| clinical and virological aspects of blood donors infected with hepatitis b virus genotypes b and c. | pathogenic and therapeutic differences among hepatitis b virus (hbv) genotypes have been documented. however, the association of virological characteristics with clinical differences among hbv genotypes remains unclear. we therefore studied the clinical and virological characteristics of taiwanese volunteer blood donors infected with hbv genotypes b and c. hbv genotypes were determined in 300 candidate blood donors positive for hbv surface antigen (hbsag), and sequences of the precore gene of th ... | 2002 | 11773087 |
| hepatitis b genotypes correlate with clinical outcomes in patients with chronic hepatitis b. | six genotypes (a-f) of hepatitis b virus (hbv) have been identified; however, the genotype-related differences in the pathogenicity of hbv remain unknown. therefore, we investigated the prevalence of hbv genotypes in taiwan and the association between distinct genotypes and severity of liver disease in a cross-sectional study. | 2000 | 10702206 |
| association between level of hepatitis b surface antigen and relapse after entecavir therapy for chronic hepatitis b virus infection. | we investigated the rate of relapse of hepatitis b virus (hbv) infection after entecavir therapy for chronic hepatitis b and the association between level of hepatitis b surface antigen (hbsag) and relapse. | 2015 | 26073492 |
| perspectives and control of hepatitis b virus infection in taiwan. | hepatitis b virus (hbv) infection is endemic in taiwan. after the implementation of universal hepatitis b vaccination, there was a significant reduction of hepatitis b surface antigen (hbsag) seropositivity and hbv-related hepatocellular carcinoma (hcc) incidence in children, teenagers, and young adults. however, the incidence of hbv-related hcc in adults remains high. through several community- and hospital-based cohort studies, the viral factors affecting the prognosis of hbv carriers have bee ... | 2015 | 26184565 |