Publications

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risk factors for herds to test positive for mycobacterium avium ssp. paratuberculosis-antibodies with a commercial milk enzyme-linked immunosorbent assay (elisa) in ontario and western canada.the objectives of this study were to identify risk factors associated with i) a mycobacterium avium subsp. paratuberculosis (map)-antibody milk enzyme-linked immunosorbent assay (map milk elisa)-positive herd status, and ii) the within-herd map milk elisa-positive prevalence in canadian dairy herds. this prospective cohort study was conducted between 2005 and 2009 on 226 herds in ontario and western canada, which participated in a voluntary risk assessment (ra)-based johne's disease control prog ...201223450860
efficacy of monensin sodium for the reduction of fecal shedding of mycobacterium avium subsp. paratuberculosis in infected dairy cattle.reducing the quantity of mycobacterium avium subsp. paratuberculosis (map) being shed by cows with johne's disease should decrease the risk of spread of this disease to young stock. previous work has suggested that monensin sodium decreases the pathologic lesions associated with johne's disease, but the impact on shedding of viable map remains unknown. after serologic screening of 32 dairy herds in southwestern ontario, 228 cows from 13 of these herds were enrolled into a randomized clinical tri ...200616631972
an epidemiological study of paratuberculosis in dairy cattle in ontario: study design and prevalence estimates.an observational study involving 304 dairy herds and three abattoirs was conducted between 1986 and 1989 to investigate the epidemiology of paratuberculosis in dairy cattle in ontario. the objectives of this paper were to describe the method of data collection for the study, to present descriptive production statistics and to present estimates of the prevalence of paratuberculosis among dairy cattle in ontario. mycobacterium paratuberculosis was isolated from the distal ileum and/or the ileoceca ...19911889036
associations between dairy production indices and lipoarabinomannan enzyme-immunoassay results for paratuberculosis.data from an epidemiological study in ontario, involving 304 dairy herds, were used to identify associations between selected production indices and lipoarabinomannan antigen serological test results for paratuberculosis (lam-elisa). analyses were conducted at both the herd and individual cow levels of organization. after analytically controlling for management and cow factors in the respective regression models, positive serological paratuberculosis status (as defined by the lam-elisa test), wa ...19911790492
prevalence of small ruminant lentivirus and mycobacterium avium subsp. paratuberculosis co-infection in ontario dairy sheep and dairy goats.infection with small ruminant lentiviruses (srlv) causes a variety of chronic inflammatory conditions that limit production. mycobacterium avium subsp. paratuberculosis (map) is also a major production-limiting disease of sheep and goats, which causes severe inflammation of the small intestine. previous studies have indicated that both srlv and map are widespread in small ruminants in ontario. this study estimated the prevalence of srlv and map co-infection. serum samples that were previously te ...201728408784
the prevalence of milk and serum antibodies to mycobacterium avium subspecies paratuberculosis in dairy herds in ontario.this study randomly surveyed 50 dairy herds in ontario; 18% and 30% of herds had 2 or more milk or serum enzyme-linked immunosorbent assay (elisa)-positive cows, respectively. the apparent cow level prevalence was 1.7% and 2.6% on the milk and serum elisa, respectively. the serum and milk assays agreed moderately.200516422065
veterinarians' perspective on a voluntary johne's disease prevention program in ontario and western canada.a survey was conducted to assess the beliefs of veterinarians on johne's disease (jd) and their attitudes towards the canadian, risk assessment based, jd prevention program. the veterinarians surveyed believed mycobacterium avium subsp. paratuberculosis may have zoonotic potential, liked the risk assessment based program, and thought it could lead to the prevention of other on-farm diseases.201020592831
monensin might protect ontario, canada dairy cows from paratuberculosis milk-elisa positivity.our objective was to define the role of monensin sodium in protecting cows from being milk-elisa positive for paratuberculosis in ontario, canada dairy herds. in total, 4933 dairy cows from 94 herds were enrolled in this cross-sectional study. forty-four of the enrolled herds were selected purposively by their herd veterinarian and another 50 herds were randomly selected from a local milk production-recording agency. a herd-management survey was completed on each farm during the months of may th ...200616787675
bovine pglyrp1 polymorphisms and their association with resistance to mycobacterium avium ssp. paratuberculosis.mycobacterium avium ssp. paratuberculosis (map) causes a chronic, granulomatous inflammatory condition of the intestines in ruminants and wild-type species. it causes significant economic losses to the dairy and beef industries owing to reduced productivity, premature culling and mortality. bovine peptidoglycan recognition protein 1 is an important pattern recognition molecule that is capable of directly killing microorganisms. the goal of this study was to identify single nucleotide polymorphis ...201121749417
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