Publications

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epidemiologic and bacteriologic evaluation of neonatal necrotizing enterocolitis.the incidence of necrotizing enterocolitis (nec) in our neonatal unit has varied from 4.7% to zero to 4.4% during three time periods. simultaneously, significant changes have occurred in the spectrum of bacterial species in the gastrointestinal tract of unaffected infants in the same unit. during the first period of increased attack rate, 82% of gastric and 88% of fecal enterobacteriaceae were e. coli and k. pneumoniae. when the attack rate decreased the frequencies were 11% (gastric) and 47% (f ...1979370356
ceftazidime-resistant klebsiella pneumoniae and escherichia coli isolates producing tem-10 and tem-43 beta-lactamases from st. louis, missouri.ceftazidime-resistant escherichia coli and klebsiella pneumoniae (49 and 102 isolates, respectively) were collected from barnes-jewish hospital, st. louis, mo., from 1992 to 1996. they were uniformly resistant to ceftazidime, generally resistant to aztreonam, and variably susceptible to cefotaxime. four representative e. coli strains and 15 klebsiella strains were examined. from one to four beta-lactamases were produced per strain, with three possible enzymes related to ceftazidime resistance: e ...19989661002
ventilator-associated pneumonia in a multi-hospital system: differences in microbiology by location.to determine whether there were differences in the microbiologic etiologies of ventilator-associated pneumonia in different clinical settings.200314649775
antimicrobial susceptibility of extended-spectrum beta-lactamase producers and multidrug-resistant acinetobacter baumannii throughout the united states and comparative in vitro activity of tigecycline, a new glycylcycline antimicrobial.as part of the tigecycline evaluation and surveillance trial, isolates of escherichia coli, klebsiella pneumoniae, and acinetobacter baumannii were collected in the united states between january 2004 and january 2006. determinations of antimicrobial susceptibility and extended-spectrum beta-lactamase (esbl) production were carried out according to the clinical and laboratory standards institute guidelines. a high percentage of esbl-producing k. pneumoniae (>or=19.0%) was detected in new jersey, ...200717403448
between community and hospital: healthcare-associated gram-negative bacteremia among hospitalized patients.healthcare-associated, community-acquired bacteremia is a subcategory of community-acquired bacteremia distinguished by recent exposure of the patient to the healthcare system before hospital admission. our objective was to apply this category to a prospective cohort of hospitalized patients with gram-negative bacteremia to determine differences in the epidemiological characteristics, treatment, and outcome of community-acquired bacteremia; healthcare-associated, community-acquired bacteremia; a ...200919803723
Clinical and bacteriological characteristics of Klebsiella pneumoniae causing liver abscess with less frequently observed multi-locus sequences type, ST163, from Singapore and Missouri, US.BACKGROUND: Klebsiella pneumoniae is the major cause of liver abscesses in several Asian countries. Differences in the type of circulating Klebsiella strains and/or the genetic make up of the host seem to be plausible explanations for this. METHODS: Two recent K. pneumoniae strains isolated from patients with liver abscess, one from Missouri in the US, and a second one from Singapore, were fully characterized by molecular typing, association of virulent genes, neutrophil phagocytosis, susceptibi ...201122138655
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