| dissemination of ctx-m type beta-lactamases in enterobacteriaceae isolates in the people's republic of china. | previously there have been a number of reports of extended spectrum beta-lactamase (esbl) producing isolates of the family enterobacteriaceae in asia. we first reported the occurrence of bla(ctx-m) in guangzhou, china, subsequently there have been reports of bla(ctx-m) from a number of other south asian countries. initial surveillance study data suggested that bla(ctx-m) might be widely distributed in china. this study examines the type of bla(ctx-m) occurring in other major population centres i ... | 2004 | 15013044 |
| a multiplex pcr-based reverse line blot hybridization (mpcr/rlb) assay for detection of bacterial respiratory pathogens in children with pneumonia. | to develop and evaluate a novel method for simultaneous identification of 12 potential bacterial pathogens in children with community-acquired pneumonia. | 2008 | 18085683 |
| combined porin loss and extended spectrum beta-lactamase production is associated with an increasing imipenem minimal inhibitory concentration in clinical klebsiella pneumoniae strains. | for this study, 150 clinical isolates of klebsiella pneumoniae were collected from one hospital in beijing, china, and assayed for minimal inhibitory concentration (mic) of imipenem. to elucidate the mechanisms responsible for imipenem mic variation among extended-spectrum beta-lactamase (esbl)-positive and -negative k. pneumoniae strains, a variety of beta-lactamase genes (bla(tem), bla(ctx-m), bla(shv), and bla(oxa)) were screened by polymerase chain reaction (pcr). the outer membrane profile ... | 2009 | 19219497 |
| antibiotic resistance patterns of gram-negative and gram-positive strains isolated from inpatients with nosocomial infections in a tertiary hospital in beijing, china from 2011 to 2014. | this study was to evaluate the resistance of antimicrobial agents against pathogens from inpatients with nosocomial infection collected in beijing, china, during 2011-2014. measurement of minimum inhibitory concentrations (mics) was carried out using the broth microdilution method with the clinical and laboratory standards institute (clsi) guidelines as the indicator. a total of 5442 gram-negative and 806 gram-positive isolates were collected in this study in 2011-2014. two carbapenem-resistant ... | 2016 | 27347770 |
| multicentre investigation of pathogenic bacteria and antibiotic resistance genes in chinese patients with acute exacerbation of chronic obstructive pulmonary disease. | a prospective observational study to investigate the distribution and antimicrobial resistance of pathogenic bacteria in patients with acute exacerbation of chronic obstructive pulmonary disease (aecopd) in beijing, china. | 2015 | 26152913 |
| analysis of drug resistance determinants in klebsiella pneumoniae isolates from a tertiary-care hospital in beijing, china. | the rates of multidrug-resistant (mdr), extensively drug-resistant (xdr) and pandrug-resistant (pdr) isolates among enterobacteriaceae isolates, particularly klebsiella pneumoniae, have risen substantially worldwide. | 2012 | 22860106 |
| a five-year surveillance of carbapenemase-producing klebsiella pneumoniae in a pediatric hospital in china reveals increased predominance of ndm-1. | to characterize carbapenem (cpm)-non-susceptible klebsiella pneumoniae (k. pneumoniae) and carbape-nemase produced by these strains isolated from beijing children's hospital based on a five-year surveillance. | 2017 | 28807096 |
| comparison of pyogenic liver abscesses caused by hypermucoviscous klebsiella pneumoniae and non-klebsiella pneumoniae pathogens in beijing: a retrospective analysis. | to perform a retrospective comparison of the clinical and radiological features of klebsiella pneumoniae (kp)-associated and non-kp-associated pyogenic liver abscesses (pla) in chinese patients. | 2013 | 23729468 |
| molecular characteristics of carbapenemase-producing enterobacteriaceae in china from 2008 to 2011: predominance of kpc-2 enzyme. | among 228 carbapenem-nonsusceptible enterobacteriaceae isolated in china, 65 were carbapenemase-producing enterobacteriaceae (cpe). among them, 41, 22, 1, and 1 produced kpc-2, imp-4, imp-8, and imp-1, respectively. kpc-2-producing cpe showed higher resistance than imp-4-producing ones. furthermore, the first outbreak of st11 kpc-2-producing klebsiella pneumoniae in a beijing second-degree hospital was identified. | 2014 | 24211218 |
| clinical and molecular characteristics of emerging hypervirulent klebsiella pneumoniae bloodstream infections in mainland china. | recently, the newly emerged hypervirulent klebsiella pneumoniae strain (hvkp) has caused great concern globally, but the clinical features and molecular characteristics of bacteremia caused by hvkp are rarely reported in mainland china. seventy patients with k. pneumoniae bacteremia were investigated to study the clinical features of hvkp infection from 2008 till 2012 in beijing chao-yang hospital. the molecular characteristics of the hvkp strains were also studied using pcr, multilocus sequence ... | 2014 | 24982067 |
| clinical and molecular characteristics of multi-clone carbapenem-resistant hypervirulent (hypermucoviscous) klebsiella pneumoniae isolates in a tertiary hospital in beijing, china. | to provide the clinical and molecular characteristics of carbapenem-resistant hypervirulent (hypermucoviscous) klebsiella pneumoniae (cr-hvkp) in a tertiary hospital in beijing, china. | 2015 | 26141415 |
| characterization of clinical multidrug-resistant escherichia coli and klebsiella pneumoniae isolates, 2007-2009, china. | various resistance mechanisms facilitate the emergence and spread of multidrug-resistance (mdr) phenotypes of escherichia coli and klebsiella pneumoniae. to elucidate the mdr mechanisms of e. coli and k. pneumoniae in china, we analyzed the antimicrobial susceptibilities of strains isolated from clinical samples in a large tertiary care hospital in beijing, china, during 2007-2009 and characterized the isolates with a cefotaxime-ciprofloxacin-amikacin (ctx-cip-ak) resistance pattern. in total, 9 ... | 2012 | 22548669 |
| flomoxef showed excellent in vitro activity against clinically important gram-positive and gram-negative pathogens causing community- and hospital-associated infections. | the objective of this study was to better understand the in vitro activity of flomoxef against clinical pathogens. a total of 545 clinical isolates, including escherichia coli, klebsiella pneumoniae, proteus mirabilis, methicillin-susceptible staphylococcus aureus (mssa), methicillin-resistant s. aureus, streptococcus pneumoniae, and streptococcus pyogenes, were isolated consecutively from clinical specimens from peking union medical college hospital in 2013. mics were determined using broth mic ... | 2015 | 25641126 |
| high prevalence of plasmid-mediated quinolone resistance determinants in escherichia coli and klebsiella pneumoniae isolates from pediatric patients in china. | in this study, the prevalence of the plasmid-mediated quinolone resistance (pmqr) genes among pediatric clinical isolates of escherichia coli and klebsiella pneumoniae was investigated. a total of 243 nonduplicate clinical isolates of e. coli and k. pneumoniae collected between january 2010 and december 2012 from beijing, china, were studied. in total, 55 isolates (22.63%) were positive for pmqr genes, the most frequently detected gene was qnrs (13.2%), followed by aac(6')-ib-cr (6.2%) and qnrb ... | 2017 | 27167505 |
| antimicrobial susceptibility patterns of clinical isolates of gram-negative bacteria obtained from intensive care units in a tertiary hospital in beijing, china. | in this study we investigated the prevalence of antimicrobial resistance in clinical isolates of gram-negative bacteria obtained from intensive care units (icus) in the people's liberation army (pla) 309 hospital located in beijing, china. between 2007 and 2010, a total of 1949 isolates of gram-negative bacteria were collected and tested using an antibiotic susceptibility assay. a marked decrease was observed in the susceptibility of acinetobacter baumannii to imipenem and amikacin as compared t ... | 2011 | 21803697 |
| [progress on biodiesel production with enzymatic catalysis in china]. | this paper reports the progress of biodiesel production with enzymatic catalysis in beijing university of chemical technology, one of the leaders in biodiesel r & d in china, which includes screening of high-yield lipase production strains, optimization and scale-up of the lipase fermentation process, lipase immobilization, bioreactor development and scale-up, biodiesel separation and purification and the by-product glycerol utilization. firstly, lipase fermentation was carried out at industrial ... | 2010 | 20954390 |
| [vicissitude of antibiotic sensitivity of gram negative bacilli in patients with infection in emergency departments in beijing during 2005 to 2007]. | to investigate changes in antibiotic sensitivity of gram negative bacilli infections among emergency patients in large hospitals in beijing during 2005 to 2007. | 2009 | 20042141 |
| presence of qnr gene in escherichia coli and klebsiella pneumoniae resistant to ciprofloxacin isolated from pediatric patients in china. | quinolone resistance in enterobacteriaceae results mainly from mutations in type ii dna topoisomerase genes and/or changes in the expression of outer membrane and efflux pumps. several recent studies have indicated that plasmid-mediated resistance mechanisms also play a significant role in fluoroquinolone resistance, and its prevalence is increasing worldwide. in china, the presence of the qnr gene in the clinical isolates of enterobacteriaceae has been reported, but this transmissible quinolone ... | 2008 | 18498643 |
| influencing the use of antibiotics in a chinese pediatric intensive care unit. | to demonstrate the effectiveness of an intervention in antibiotics prescribing, and evaluate the use of antibiotics in the pediatric intensive care unit (picu) at the beijing children's hospital. | 2008 | 18493864 |
| [prevalence of atypical pathogens in adult patients with community-acquired pneumonia in beijing]. | to study the pathogens in community-acquired pneumonia (cap), especially the prevalence of atypical pathogens. | 2004 | 14989822 |
| characterization of extended spectrum beta-lactamase-producing klebsiella pneumoniae from beijing, china. | fourteen clinical isolates of klebsiella pneumoniae with extended-spectrum beta-lactamases (esbls) were detected by the double disk synergy test and the etest esbl strip. co-resistances included high mics for aminoglycosides, fluoroquinolones, tetracyclines, and trimethoprim/sulphamethoxazole. co-resistance was not observed in five of the 14 strains. these isolates were all genetically distinct as determined by the automated ribotyping method. isoelectric focusing documented the presence of mult ... | 2001 | 11516943 |