| age trend in hepatitis c virus genotype distribution as seen in a brussels teaching hospital. | the hepatitis c virus genotype distribution was studied among age groups in 501 referred patients with chronic hepatitis c by inno-lipa hcv ii (innogenetics, belgium). ten patients had coinfection with several genotypes. two hundred seventy of 491 singly infected individuals (57%) had 1b, 66 (13.4%) 3a, 57 (11.6%) 1a. hcv subtype 1b was predominant but its prevalence increased with age (76.5% of patients born in the '20s, 39.3% in the '70s) (p < 0.0001). three possibilities could explain the shi ... | 2001 | 11603251 |
| prevalence of hepatitis c antibodies in a large sample of belgian healthcare workers. | to assess the risk of hepatitis c virus (hcv) infection among belgian (flemish) healthcare workers. | 2000 | 10738992 |
| characteristics of non-aids-defining malignancies in the haart era: a clinico-epidemiological study. | non-aids-defining malignancies (nadm) are becoming a major cause of mortality in the era of highly active antiretroviral therapy. we wished to investigate the incidence, risks factors and outcome of nadm in an urban cohort. | 2011 | 21443771 |
| hcv genotype distribution in flanders and brussels (belgium): unravelling the spread of an uncommon hcv genotype 5a cluster. | in order to study the hepatitis c virus (hcv) epidemiology in flanders, belgium, the hcv genotype of 2,301 patients diagnosed with hcv between 2001 and 2009 was determined. hcv genotyping was conducted using the versant lipa 1.0 or versant lipa 2.0 assay. to explore the transmission history of a remarkable cluster of the rarely found hcv genotype 5a, face-to-face interviews based on detailed questionnaires and maximum likelihood phylogenetic analysis were performed. hcv genotype 1 was the most p ... | 2010 | 20830499 |
| impact of pnpla3 (rs738409 c>g) polymorphism on fibrosis progression and steatosis in chronic hepatitis c. | only 20% of patients with chronic hepatitis c (chc) will develop cirrhosis and fibrosis progression remains highly unpredictable. a recent genome-wide association study identified a genetic variant in the pnpla3 gene (rs738409 c>g) associated with steatosis, that was further demonstrated to influence severity of fibrosis in non-alcoholic fatty liver disease. our aim was to study the impact of this polymorphism on histological liver damage and response to antiviral therapy in chc. 537 caucasian c ... | 2011 | 21488075 |