| human t-lymphotropic virus type-i infection, antibody titers and cause-specific mortality among atomic-bomb survivors. | there have been few longitudinal studies on the long-term health effects of human t-lymphotropic virus type-i (htlv-i) infection. the authors performed a cohort study of htlv-i infection and cause-specific mortality in 3,090 atomic-bomb survivors in nagasaki, japan, who were followed from 1985-1987 to 1995. the prevalence of htlv-i seropositivity in men and women was 99/1,196 (8.3%) and 171/1,894 (9.0%), respectively. during a median follow-up of 8.9 years, 448 deaths occurred. there was one non ... | 1998 | 9765614 |
| human t-cell lymphotropic virus type-1 infection and risk of cancer: 15.4 year longitudinal study among atomic bomb survivors in nagasaki, japan. | the objective of the present study was to investigate the association between human t-lymphotropic virus type-1 (htlv-1) infection and cancer risk in a longitudinal study. the study population consisted of 2729 atomic bomb survivors in nagasaki prefecture, japan, who had no previous history of cancer at baseline. the baseline survey, including analysis of antibody to htlv-1, took place during 1985-1987 and follow-up was performed until the end of 2001. there were 553 incident cases of malignant ... | 2006 | 16734733 |
| hepatocellular carcinoma among atomic bomb survivors: significant interaction of radiation with hepatitis c virus infections. | we conducted a nested case-control study within the cohort of japanese survivors of the 1945 atomic bombings to study the joint effects of hbv and hcv with radiation on the risk of hcc. among subjects who received autopsies during 1954-1988, we analyzed archival tissue samples for 238 pathologically confirmed hcc cases and 894 controls who died from diseases other than liver cancer. using logistic regression and adjusting for potential confounders and other factors, we found a statistically sign ... | 2003 | 12478671 |
| geographic distribution of the incidence of adult t-cell leukemia/lymphoma and other malignancies in nagasaki prefecture, japan. | it remains unclear whether human t-cell lymphotropic virus type-i (htlv-i) infection is associated with an increased risk of malignancies other than adult t-cell leukemia/lymphoma. | 2002 | 12411568 |
| prevalence of anti-hepatitis c virus antibody and chronic liver disease among atomic bomb survivors. | to investigate whether exposure to atomic bomb radiation altered the prevalence of hepatitis c virus (hcv) infection or accelerated the progress toward chronic hepatitis after hcv infection, the seropositivity of antibody to hepatitis c virus (anti-hcv) was determined for 6,121 participants in the adult health study of atomic bomb survivors in hiroshima and nagasaki. the seropositivity of anti-hcv antibody was 2.5 times higher among those with a history of blood transfusion and 1.2 times higher ... | 2000 | 10856960 |
| clinical features of 89 patients with autoimmune hepatitis in nagasaki prefecture, japan. | we examined the clinical characteristics of 89 patients with autoimmune hepatitis (aih) in nagasaki prefecture, japan, and assessed the usefulness of a provisional scoring system for the diagnosis of aih proposed by the international autoimmune hepatitis group in 1993. the majority of patients were middle-aged women in their fifties. all patients showed a hepatitic picture. forty-three patients (48%) had an insidious or chronic onset, while 34 (38%) had an acute onset, and 12 (14%) had liver cir ... | 1999 | 10213122 |
| clinical manifestations of hbsag and anti-hcv negative chronic liver disease in nagasaki prefecture, japan. | the discovery of hepatitis c virus (hcv) has enabled the diagnosis of type c chronic liver disease, which had in the past been diagnosed as part of non-a, non-b chronic liver disease. although most cases with chronic liver disease are caused by hepatitis b virus (hbv) or hcv infection, there are still cases of non-b, non-c chronic liver disease. forty patients with chronic liver disease, who were seronegative for hepatitis b surface antigen and antibody to hcv, were followed for a mean period of ... | 1996 | 8894732 |
| changes in the prevalence of hepatitis b and c infection in patients with hepatocellular carcinoma in the nagasaki prefecture, japan. | the development of hepatocellular carcinoma (hcc) is very closely associated with chronic liver disease. in the present study, the prevalence of the hepatitis b virus (hbv) and hepatitis c virus (hcv) infection as a causative role in the development of hcc was analysed in 253 patients with hcc, who were admitted to our hospital during 1976-90. among these patients, 68 (27%) were positive for hbsag but negative for anti-hcv antibody (group i); in contrast, 147 (58%) were negative for hbsag but po ... | 1993 | 8395554 |