| active hepatitis c infection and hcv genotypes prevalent among the idus of khyber pakhtunkhwa. | abstract: injection drug users (idus) are considered as a high risk group to develop hepatitis c due to needle sharing. in this study we have examined 200 injection drug users from various regions of the khyber pakhtunkhwa province for the prevalence of active hcv infection and hcv genotypes by immunochromatographic assays, rt-pcr and type-specific pcr. our results indicated that 24% of the idus were actively infected with hcv while anti hcv was detected among 31.5% cases. prevalent hcv genotype ... | 2011 | 21711541 |
| prevalence of hepatitis-c virus genotypes and potential transmission risks in malakand khyber pakhtunkhwa, pakistan. | hepatitis c virus (hcv) is a leading cause of chronic liver disease and frequently progresses towards liver cirrhosis and hepatocellular carcinoma (hcc). this study aimed to determine the prevalence of hcv genotypes and their association with possible transmission risks in the general population of malakand division. | 2017 | 28830526 |
| frequency distribution of hcv genotypes among chronic hepatitis c patients of khyber pakhtunkhwa. | abstract: background: hepatitis c virus (hcv) genotypes frequency is important for the predication of response to therapy and duration of treatment. despite variable response rates experienced in the case of interferon (ifn) -based therapies, there was scarcity of data on hcv genotypes frequency in khyber pakhtunkhwa (kpk). study design a total of 200 blood samples were collected from chronic hcv patients prior to the initiation of anti-viral therapy. the study population included patients from ... | 2011 | 21521506 |
| molecular epidemiology of hcv among health care workers of khyber pakhtunkhwa. | studies of the molecular epidemiology and risk factors for hepatitis c virus (hcv) in health care workers (hcws) of peshawar, khyber pakhtunkhwa region are scarce. lack of awareness about the transmission of hcv and regular blood screening is contributing a great deal towards the spread of hepatitis c. this study is an attempt to investigate the prevalence of hcv and its possible association with both occupational and non-occupational risk factors among the hcws of peshawar. | 2011 | 21385397 |
| hepatitis c virus genotypes circulating in district swat of khyber pakhtoonkhaw, pakistan. | hepatitis c virus (hcv) is the leading cause of chronic hepatitis worldwide and its subtypes/genotypes are clinically important for clinical management and vaccine development. the present study describes frequency distribution of different hcv genotypes and their treatment status in hcv rna positive patients from district swat. a total of 185 hcv infected sera were analyzed by molecular genotyping assay. the most prevalent genotype was 3a (34.1%), followed by 2a (8.1%), 3b (7%) and 1a (5.4%). t ... | 2011 | 21235746 |
| seroprevalence of hepatitis c in pregnant females of hazara division. | hepatitis c virus (hcv), the causative agent of hepatitis c is prevalent in different countries including pakistan. studies have been conducted on various aspects of hcv in pakistan. the present study was planed to see the prevalence of hepatitis c in pregnant females of hazara division. | 2009 | 21067033 |
| molecular epidemiology of hepatitis c virus genotypes in khyber pakhtoonkhaw of pakistan. | six major hepatitis c virus (hcv) genotypes and hundreds of subtypes have been identified globally. all these genotypes are generally studied for epidemiology, their vaccine development and clinical management. this article comments the frequency distribution of various hcv genotypes circulate in different areas/districts of khyber pakhtoonkhaw province of pakistan. sum of 415 hcv rna pcr positive sera samples were tested by a molecular genotyping assay. data analysis revealed that out of these ... | 2010 | 20796270 |
| prevalence of hepatitis b and c in internally displaced persons of war against terrorism in swat, pakistan. | background: hepatitis b and c are the most common blood-borne liver infections worldwide. according to the recent estimates, 270-300 million people worldwide are infected with hepatitis c virus (hcv) and more than 2 billion people have been infected with the hepatitis b virus (hbv). transmission of these viruses is carried out by exposure to infectious blood or body fluids containing blood. methods: five-hundred and ninety (290 males and 300 females, 5-65 years) internally displaced persons (idp ... | 2010 | 20601693 |
| frequency distribution of hepatitis c virus genotypes in different geographical regions of pakistan and their possible routes of transmission. | information regarding hepatitis c virus genotypes and subtypes circulating in pakistan and various risk factors for their transmission are not known well. the specific objective of this study was to find out the frequency of various hcv genotypes present in well-characterized pakistani hcv isolates and their possible routes of transmission. | 2008 | 18498666 |
| frequency and clinical course of hepatitis e in tertiary care hospitals. | to find out the frequency of hepatitis e virus as a cause of acute hepatitis and its clinical course in hospitalized patients. | 2004 | 15487036 |
| response rates of standard interferon therapy in chronic hcv patients of khyber pakhtunkhwa (kpk). | abstract: background: interferon based therapy is used to eradicate the hepatitis c virus from the bodies of the infected individuals. hcv is highly prevalent in khyber pakhtunkhwa (kpk) that is why it is important to determine the response of standard interferon based therapy in chronic hcv patients of the region. study design a total of 174 patients were selected for interferon based therapy. the patients were selected from four different regions of kpk. after confirmation of active hcv infec ... | 2012 | 22244529 |
| determination of hcv genotypes and viral loads in chronic hcv infected patients of hazara pakistan. | hepatitis c virus (hcv) genotype and viral load are two significant predictive variables knowledge of which might persuade treatment decisions. the objective of the present study was to identify the distribution of different hcv genotypes circulating in the study area and to estimate viral load in chronically hcv infected patients. out of total 305 hcv positive patients, 177 (58%) were males and 128 (42%) were females. frequency breakup of the hcv positive patients was 169, 69, 38 and 29 from ab ... | 2011 | 21982599 |
| hepatitis c virus genotypes in pakistan: a systemic review. | background and aim: phylogenetic analysis has led to the classification of hepatitis c virus (hcv) into 1-6 major genotypes. hcv genotypes have different biological properties, clinical outcome and response to antiviral treatment and provide important clues for studying the epidemiology, transmission and pathogenesis. this article deepens the current molecular information about the geographical distribution of hcv genotypes and subgenotypes in population of four provinces of pakistan. 34 publish ... | 2011 | 21902822 |
| rising burden of hepatitis c virus in hemodialysis patients. | abstract: aim: high prevalence of hepatitis c virus (hcv) has been reported among the dialysis patients throughout the world. no serious efforts were taken to investigate hcv in patients undergoing hemodialysis (hd) treatment who are at great increased risk to hcv. hcv genotypes are important in the study of epidemiology, pathogenesis and reaction to antiviral therapy. this study was performed to investigate the prevalence of active hcv infection, hcv genotypes and to assess risk factors associa ... | 2011 | 21920054 |
| prevalence of hcv among the high risk groups in khyber pakhtunkhwa. | hepatitis c is an infectious disease, caused by blood borne pathogen; the hepatitis c virus. in this study we analyzed blood samples collected from various risk groups for the prevalence of anti-hcv and active hcv infection with the help of immunochromtographic tests and nested pcr. the prevalence of active hcv infection among the high risk groups was 15.57% (26/167). the prevalence of hcv in individual risk groups was 15%, 28%, 8%, 14.28% and 14.28% in the case of thalassemics, dialysis, major ... | 2011 | 21663685 |
| prevalence of active hepatitis c virus infection in district mansehra pakistan. | prevalence of active hepatitis c virus (hcv) infection in apparently healthy inhabitants of district mansehra, pakistan was surveyed during september, 2009 to may, 2010. subjects of different age and gender groups were analyzed through random blood sampling from people of three areas viz; tehsil mansehra, tehsil balakot and tehsil oghi. sum of 400 individuals, 300 male and 100 females with age groups from 10 years to 50 and above were included in the study. all the individuals were screened for ... | 2010 | 21092143 |
| prevalence of hiv, hcv and sexually transmitted infections among injecting drug users in rawalpindi and abbottabad, pakistan: evidence for an emerging injection-related hiv epidemic. | to measure the prevalence of hepatitis c virus (hcv), hiv and sexually transmitted infections (sti) among injecting drug users (idus) in rawalpindi and abbottabad and to examine risk factors associated with hiv and hcv. | 2009 | 19307346 |
| frequency of hepatitis c infection in diabetic patients. | diabetic patients are at an increased risk of acquiring hepatitis c virus (hcv) infection owing to the nature of the disease and its inherent complications or frequent parentral exposure. on the other hand hcv infection may itself contribute to the development of diabetes mellitus. the epidemiological evidence of this association has not been studied in pakistan at a population level and its exact biological mechanisms are not obvious. objective of this study was to study the frequency of hcv in ... | 2007 | 17867480 |
| hepatitis c virus prevalence and genotype distribution in pakistan: comprehensive review of recent data. | hepatitis c virus (hcv) is endemic in pakistan and its burden is expected to increase in coming decades owing mainly to widespread use of unsafe medical procedures. the prevalence of hcv in pakistan has previously been reviewed. however, the literature search conducted here revealed that at least 86 relevant studies have been produced since the publication of these systematic reviews. a revised updated analysis was therefore needed in order to integrate the fresh data. a systematic review of dat ... | 2016 | 26819533 |
| identification of mutation sites in hepatitis c virus genotype 3a in non-responders to combination therapy with interferon- αlfa and ribavirin in residents of khyber pakhtunkhwa province pakistan. | this study was carried out to search for mutations in the gene encoding for non- structural protein 5a, specifically in the interferon sensitivity determining region of hepatitis c virus (hcv) genotype 3a, isolated from serum samples of patients not responding to treatment with oral ribavirin and interferon alpha injections. | 2017 | 28586597 |