Publications

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group a streptococcal infection in patients presenting with a sore throat at an accident and emergency department: prospective observational study.to determine the prevalence of group a streptococcal infection and to evaluate the predictive value of clinical findings and rapid streptococcal antigen detection testing in patients presenting with a sore throat or suspected clinically to have acute pharyngitis.200211937663
molecular characterization of the 2011 hong kong scarlet fever outbreak.a scarlet fever outbreak occurred in hong kong in 2011. the majority of cases resulted in the isolation of streptococcus pyogenes emm12 with multiple antibiotic resistances. phylogenetic analysis of 22 emm12 scarlet fever outbreak isolates, 7 temporally and geographically matched emm12 non-scarlet fever isolates, and 18 emm12 strains isolated during 2005-2010 indicated the outbreak was multiclonal. genome sequencing of 2 nonclonal scarlet fever isolates (hku16 and hku30), coupled with diagnostic ...201222615319
a hong kong family with respiratory illness. 200312853197
comparative in vitro activity of a pharmacokinetically enhanced oral formulation of amoxicillin/clavulanic acid (2000/125 mg twice daily) against 9172 respiratory isolates collected worldwide in 2000.a new, pharmacokinetically enhanced, oral formulation of amoxicillin/clavulanic acid has been developed to overcome resistance in the major bacterial respiratory pathogen streptococcus pneumoniae, while maintaining excellent activity against haemophilus influenzae and moraxella catarrhalis, including beta-lactamase producing strains. this study was conducted to provide in vitro susceptibility data for amoxicillin/clavulanic acid and 16 comparator agents against the key respiratory tract pathogen ...200415494258
a review of necrotising fasciitis in the extremities.to review currently available evidence on the epidemiology and methods of management for necrotising fasciitis, with particular reference to hong kong.200919197096
epidemiologic analysis of invasive and noninvasive group a streptococcal isolates in hong kong.since the mid-1980s, there has been a resurgence of severe forms of invasive group a streptococcal (gas) disease in many western countries. in hong kong, a similar increase has also been observed in recent years. one hundred seven gas isolates collected from 1995 to 1998 from individuals with necrotizing fasciitis, toxic shock syndrome, meningitis, or other type of bacteremic sepsis (invasive group, n = 24) as well as from individuals with minor skin and throat infections (noninvasive group, n = ...200312624012
uncommon cause of severe pneumonia: co-infection of influenza b and streptococcus.influenza and pneumococcus co-infection can cause severe morbidity and mortality. usually, this entails influenza a, while infection by influenza b is rarely serious. the literature describes influenza a epidemics leading to prolific loss of lives, notably the 1918 epidemic was blamed for the deaths of 40 to 50 million people. in this report, four patients were infected by influenza b during the influenza epidemic of 2011/12 in hong kong. all of them were previously healthy and had no chronic di ...201324310663
epidemiological analysis of streptococcus pyogenes infections in hong kong.the aim of this study was to characterise clinical and microbiological features of isolates obtained from both invasive and non-invasive streptococcus pyogenes infections in hong kong, between october 2005 and april 2008.200920001348
streptococcus pyogenes in general practice in hong kong. 19684881080
re-emergence of scarlet fever: old players return? 201627249582
emergence of scarlet fever streptococcus pyogenes emm12 clones in hong kong is associated with toxin acquisition and multidrug resistance.a scarlet fever outbreak began in mainland china and hong kong in 2011 (refs. 1-6). macrolide- and tetracycline-resistant streptococcus pyogenes emm12 isolates represent the majority of clinical cases. recently, we identified two mobile genetic elements that were closely associated with emm12 outbreak isolates: the integrative and conjugative element ice-emm12, encoding genes for tetracycline and macrolide resistance, and prophage φhku.vir, encoding the superantigens ssa and spec, as well as the ...201525401300
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