mycobacterium avium subsp. paratuberculosis and multiple sclerosis in sardinian patients: epidemiology and clinical features.mycobacterium avium subspecies paratuberculosis (map) is an infectious factor recently found in association with multiple sclerosis (ms) in sardinia.201323439580
anti mycobacterium avium subsp. paratuberculosis heat shock protein 70 antibodies in the sera of sardinian patients with multiple sclerosis.heat shock protein (hsp) family members are highly conserved in both prokaryotic and eukaryotic organisms and are known to be immunodominant antigens in many bacteria. in particular, hsp70 has been linked to multiple sclerosis (ms), even if the available data are contradictory. since different studies conducted on sardinian subjects, have linked mycobacterium avium subspecies paratuberculosis (map) presence to ms disease, and in view of the fact that human hsp70 is highly homologue to the majori ...201324075312
mycobacterium avium subsp. paratuberculosis is not discerned in diabetes mellitus patients in hyderabad, india.mycobacterium avium ssp. paratuberculosis (map) is an obligate intracellular pathogen. it causes chronic intestinal inflammation in ruminants known as johne's disease and is associated with human crohn's disease. furthermore, association of map with other autoimmune diseases, such as type-1 diabetes, has been established in patients from sardinia (italy) which is a map endemic and genetically isolated region. due to largest livestock population and consequently high map prevalence amidst a very ...201424863528
type 1 diabetes in sardinia: facts and hypotheses in the context of worldwide epidemiological data.type 1 diabetes (t1d) results from an autoimmune destruction of insulin-producing beta cells that requires lifelong insulin treatment. while significant advances have been achieved in treatment, prevention of complications and quality of life in diabetic people, the identification of environmental triggers of the disease is far more complex. the island of sardinia has the second highest incidence of t1d in the world (45/100,000), right after finland (64.2/100,000). the genetic background as well ...201727639869
relationship between crohn's disease, infection with mycobacterium avium subspecies paratuberculosis and slc11a1 gene polymorphisms in sardinian study the association between crohn's disease (cd), mycobacterium avium subspecies paratuberculosis (map), and genetic factors by examining the role of natural resistance-associated macrophage protein 1 (nramp1) gene polymorphisms (now slc11a1) in sardinian patients with cd and controls.200617131479
association of mycobacterium avium subsp. paratuberculosis with multiple sclerosis in sardinian patients.mycobacterium avium subsp. paratuberculosis (map) infection is highly spread in the ruminant herds of sardinia, in the western mediterranean. the objective of this study was to investigate prevalence of map infection in association with multiple sclerosis (ms) using clinical specimen from patients and controls. we analyzed samples for the presence of map specific dna and to demonstrate humoral response to a map protein (map2694), a predicted homologue of the t-cell receptor gamma-chain/complemen ...201121533236
recognition of zinc transporter 8 and map3865c homologous epitopes by hashimoto's thyroiditis subjects from sardinia: a common target with type 1 diabetes?mycobacterium avium subspecies paratuberculosis (map) asymptomatic infection has been previously linked to type 1 diabetes (t1d) and multiple sclerosis. an association between map infection and hashimoto's thyroiditis (ht) was also proposed only in a case report. this study aimed to investigate the robustness of the latter association, testing a large cohort of ht and healthy control (hcs) subjects, all from sardinia. prevalence of anti-map3865c abs was assessed by indirect enzyme-linked immunos ...201424830306
identification of non-tuberculous mycobacteria from clinical samples.non-tuberculous mycobacterial infections cause morbidity worldwide. ntm are considered opportunistic pathogens, and several species have been associated with human disease which has typically pulmonary, skin and soft tissue, lymphatic or disseminated presentation. this study evaluated the distribution of non-tuberculous mycobacteria in sardinia. mycobacterium avium, mycobacterium gordonae and mycobacterium xenopi were frequently found. our results agreed with literature data both for the frequen ...201324177303
role of interferon-beta in mycobacterium avium subspecies paratuberculosis antibody response in sardinian ms patients.mycobacterium avium subspecies paratuberculosis (map) is associated with ms in sardinia. because anti-map antibodies (abs) were more frequent in interferon-beta treated patients, we hypothesize that interferon-beta could interact with the immune system.201525598492
antibodies against proinsulin and homologous map epitopes are detectable in hashimoto's thyroiditis sardinian patients, an additional link of association.hashimoto's thyroiditis (ht) is the prevailing organ-specific autoimmune disease in sardinia, often complicated with other autoimmune disorders, most commonly type 1 diabetes (t1d). while numerous studies describe levels of anty-thyroid antibodies (abs) in t1d patients, few papers evaluate the status of anti-islet autoimmunity in subjects affected by ht. previously, we portrayed mycobacterium avium subspecies paratuberculosis (map) as an environmental factor strongly associated with both disease ...201526192189
detection and isolation of mycobacterium avium subspecies paratuberculosis from intestinal mucosal biopsies of patients with and without crohn's disease in sardinia.sardinia is an island community of 1.6 million people. there are also about 3.5 million sheep and one hundred thousand cattle in which johne's disease and mycobacterium avium subspecies paratuberculosis infection are endemic. the present study was designed to determine what proportion of people in sardinia attending for ileocolonoscopy with or without crohn's disease were infected with this pathogen.200515984976
are mycobacterium avium subsp. paratuberculosis and epstein-barr virus triggers of multiple sclerosis in sardinia?sardinia acts as an ideal setting for multiple sclerosis (ms) studies because its prevalence of ms is one of the highest worldwide. several pathogens have been investigated amongst 119 sardinian ms patients and 117 healthy controls to determine whether they might have a role in triggering ms in genetically predisposed individuals. mycobacterium avium subsp. paratuberculosis (map) and epstein barr virus dna were detected in 27.5% and 17.3%, respectively, of the ms patients. moreover an extremely ...201222261119
mycobacterium avium subsp. paratuberculosis, genetic susceptibility to crohn's disease, and sardinians: the way ahead.the present study was performed to determine what proportion of people in sardinia with or without crohn's disease were infected with mycobacterium avium subspecies paratuberculosis and had a preponderance of allelic variants of nod 2, an intracellular protein involved in crohn's disease susceptibility. genetic analysis of the alleles of the nod 2/card 15 gene (ins c 3020, g 908 r, and r 702 w alleles), linked to susceptibility or genetic predisposition to crohn's disease in humans, was carried ...200516207995
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