Publications

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frentizole, a novel immunosuppressive, and azathioprine: their comparative effects on host resistance to pseudomonas aeruginosa, candida albicans, herpes simplex virus, and influenza (ann arbor) virus.frentizole, 1-(6-methoxy-2-benzothiazolyl)-3-phenyl urea, a new immunosuppressive agent, and azathioprine were administered subcutaneously at predetermined immunosuppressive dose levels of azathioprine and up to 50 times an immunosuppressive dose level of frentizole. after 10 days of treatment at these dose levels, the experimental groups were inoculated intraperitoneally with pseudomonas aeruginosa or herpes simplex virus, inoculated intraveneously with candida albicans, or infected by aerosol ...1977188761
candida albicans in women.ninety-two pregnant and nonpregnant patients were randomly selected from two obstetric-gynecologic clinics for the purpose of investigating factors that affect the incidence and severity of vaginal candidiasis. six factors were found to be significantly associated with the incidence of candida albicans: drug addiction, obesity, birth control pills, pregnancy, antibiotic therapy, and diabetes mellitus.19751105432
major trends in the microbial etiology of nosocomial infection.to determine trends in the microbial etiology of nosocomial infections in the 1980s, surveillance data on the microbiology of documented nosocomial infection reported to the national nosocomial infections surveillance system and from the university of michigan hospital were analyzed. antimicrobial susceptibility data on selected pathogens from both sources were also reviewed. overall, escherichia coli decreased from 23% of infections in 1980 to 16% in 1986-1989, klebsiella pneumoniae dropped fro ...19911928195
opportunistic fungi in detroit's rats and opossum.four norway rats (rattus norvegicus) and one opossum (didelphis virginiana) were surveyed for the presence of fungi. eighteen different fungi were isolated from rat samples and six from the opossum, including trichophyton mentagrophytes. hair and skin scrapings from laboratory raised norway rats, bedding and air from the room yielded only penicillium sp.19806991950
genetic similarity of candida albicans strains from vaginitis patients and their partners.the moderately repetitive sequence ca3 was used to fingerprint strains of candida albicans isolated from vulvovaginal infections of 10 women and strains isolated from their male partners. the dendron software package was then used to compare the dna fingerprints of these strains with those of vaginal commensals from women from the same geographical locale, vaginal commensals from women from a different geographical locale, and commensals from male partners of asymptomatic women from the same geo ...19938417030
genotypic analysis of a cluster of systemic candida albicans infections in a neonatal intensive care unit.five very low birth weight infants developed systemic candida albicans infection during a 6-week period in an urban neonatal intensive care unit. in an effort to assess whether a common source outbreak was present, the genomic dna of the clinical isolates was compared by ecori and xbai restriction fragment analysis and southern blot hybridization with 27a, a species-specific, transposon-like probe. although the restriction fragment analysis suggested strong similarities among the isolates, the h ...19958745019
risk factors for vulvovaginal candidiasis: a case-control study among university students.vulvovaginal candidiasis (vvc) is a common inflammatory condition caused by vaginal overgrowth of candida albicans. typical symptoms include pruritus and discharge. to test the association between several hypothesized risk factors and vvc, we conducted a case-control study among university students, with both clinic and population controls. symptomatic, culture-proven vvc was associated with receptive oral sex twice or more in the previous 2 weeks [vs not at all, odds ratio (or) = 3.5; 95% confi ...19968834559
trends in species causing fungaemia in a tertiary care medical centre over 12 years.trends in the species of yeast causing fungaemia over a 12-year period at a large tertiary care medical centre were reviewed. a total of 966 unique episodes of fungaemia occurred in 898 patients. there was an overall trend toward fewer fungaemic episodes due to candida albicans and more due to candida glabrata and candida parapsilosis. however, c. albicans remained the predominant species causing fungaemia, and the proportion due to other species varied from year to year. candida glabrata was di ...200111820256
differences in patient risk factors and source of candidaemia caused by candida albicans and candida glabrata.summary there is an increasing frequency of candidaemia caused by candida glabrata which has decreased in vitro susceptibility to fluconazole. differences in risk factors for candidaemia caused by c. glabrata and c. albicans have not been formally evaluated in a diverse patient group. we performed a retrospective study of adult inpatients from january 1, 2003 to april 30, 2008 with c. glabrata and c. albicans candidaemia at a single tertiary care centre in detroit, michigan to evaluate for diffe ...200920051013
candida transmission and sexual behaviors as risks for a repeat episode of candida vulvovaginitis.to assess associations between female and male factors and the risk of recurring candida vulvovaginitis.200314709186
risk factors for colonization with yeast species in a veterans affairs long-term care facility.to assess colonization and serious infection with yeasts and the risk factors that are associated with colonization by these organisms.19989670871
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