relative frequency of nosocomial pathogens at a university hospital during the decade 1980 to 1989.we compared the relative frequency of pathogens isolated from 1985 to 1989 (n = 4358) with those isolated from 1980 to 1984 (n = 5290) in a university hospital to determine trends in the relative importance of pathogens causing nosocomial infection.19921524267
caspofungin for invasive candidiasis at a tertiary care medical center.caspofungin is emerging as first-line therapy for invasive candidiasis. data on the use of caspofungin for treatment for invasive candidiasis are limited to clinical trials and case reports. we report a single-center experience with 104 consecutive courses of caspofungin for the treatment of invasive candidiasis to evaluate a real-world performance of this drug.200617071169
candida spp. urinary tract infections in 13 dogs and seven cats: predisposing factors, treatment, and outcome.records from 20 animals (13 dogs, seven cats) with candida spp. urinary tract infections were reviewed. six candida spp. were isolated; candida albicans was the most common isolate. concurrent diseases or nonantifungal drugs administered within 1 month of isolation included antibiotics (n=16), corticosteroids (n=6), diabetes mellitus (n=4), nonurogenital neoplasia (n=3), and noncandidal urogenital disease (n=14). all animals had sources of local or systemic immune compromise that likely predispo ...200312755200
lack of genetic differentiation between two geographically diverse samples of candida albicans isolated from patients infected with human immunodeficiency virus.the patterns of genetic variation of samples of candida albicans isolated from patients infected with human immunodeficiency virus in durham, n.c., and vitória, brazil, were compared. genotypes for 126 strains were obtained at 16 polymorphic restriction sites distributed on nine pcr fragments. the results indicated evidence of clonality both within and between these two geographically diverse samples. the samples are genetically very similar, with little evidence of genetic differentiation.19999973371
a protective endophyte of maize: acremonium zeae antibiotics inhibitory to aspergillus flavus and fusarium verticillioides.the maize endophyte acremonium zeae is antagonistic to kernel rotting and mycotoxin producing fungi aspergillus flavus and fusarium verticillioides in cultural tests for antagonism, and interferes with a. flavus infection and aflatoxin contamination of preharvest maize kernels. chemical studies of an organic extract from maize kernel fermentations of acremonium zeae (nrrl 13540), which displayed significant antifungal activity against aspergillus flavus and f. verticillioides, revealed that the ...200516018316
altenuene derivatives from an unidentified freshwater fungus in the family tubeufiaceae.four new altenuene derivatives called dihydroaltenuenes a (1) and b (2) and dehydroaltenuenes a (3) and b (4), along with five known compounds, including isoaltenuene (5), altenuene (6), and 5'-epialtenuene (7), were isolated from cultures of an unidentified freshwater aquatic fungal species in the family tubeufiaceae. the structures of 1-4 were determined by analysis of nmr and ms data. the relative stereochemistry was determined on the basis of (1)h nmr j-values and noe data, while the absolut ...200616643037
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