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in vitro activity of voriconazole against candida species isolated in taiwan.the activity of voriconazole was determined against 285 candida species consisting of 53 resistant isolates, 43 susceptible-dose dependent and 189 isolates susceptible to fluconazole. the mic(50) and mic(90) to fluconazole were 8 and 64 mg/l, respectively. the range of minimum inhibitory concentrations (mics) to voriconazole was from 0.0325 to 2 mg/l and the mic(50) and mic(90) were 0.125 and 0.5 mg/l, respectively. only 3 of 285 tested isolates had mics to voriconazole equal to 2 mg/l. a total ...200415325436
the distribution of species and susceptibility of amphotericin b and fluconazole of yeast pathogens isolated from sterile sites in taiwan.to study the demographic changes of yeasts causing invasive infections in taiwan, especially with respect to species distribution and antifungal susceptibility, we analyzed isolates obtained from four sterile sites of patients in 19 hospitals in 2002 (155 strains) and again from the same hospitals in 2006 (208 strains). blood was the most common source of the yeasts, accounting for 73.8% of the total isolates, followed by ascites (21.5%), cerebrospinal fluid (3%), and synovia (1.7%). candida alb ...201020141372
community-onset candidemia at a university hospital, 1995-2005.although not all candidemias are hospital-acquired, data on clinical epidemiology for the community-onset candidemia are limited. this retrospective study was conducted to describe predisposing factors and outcomes of community-onset candidemias.200717712471
metschnikowia bicuspidata dominates in taiwanese cold-weather yeast infections of macrobrachium rosenbergii.at water temperatures below 17 degrees c, yeast infections often occurred in 6 to 11 mo old giant freshwater prawn macrobrachium rosenbergii (8 to 12 cm) in taiwan from may 2001 to december 2003, with a cumulative mortality of 20 to 95%. gross signs of disease included milky hemolymph, a yellow exoskeleton, opaque muscles, and a swollen hepatopancreas (hp). histopathology included marked edema and extensive necrotic lesions associated with large numbers of yeast aggregates and inflammation withi ...200717629113
multilocus sequence typing for analyses of clonality of candida albicans strains in taiwan.multilocus sequence typing (mlst) was used to characterize the genetic profiles of 51 candida albicans isolates collected from 12 hospitals in taiwan. among the 51 isolates, 16 were epidemiologically unrelated, 28 were isolates from 11 critically ill, human immunodeficiency virus (hiv)-negative patients, and 7 were long-term serial isolates from 3 hiv-positive patients. internal regions of seven housekeeping genes were sequenced. a total of 83 polymorphic nucleotide sites were identified. ten to ...200616757617
antifungal susceptibilities of clinical isolates of candida species, cryptococcus neoformans, and aspergillus species from taiwan: surveillance of multicenter antimicrobial resistance in taiwan program data from 2003.the susceptibilities of nonduplicate isolates to six antifungal agents were determined for 391 blood isolates of seven candida species, 70 clinical isolates (from blood or cerebrospinal fluid) of cryptococcus neoformans, and 96 clinical isolates of four aspergillus species, which were collected in seven different hospitals in taiwan (as part of the 2003 program of the study group surveillance of multicenter antimicrobial resistance in taiwan). all isolates of candida species other than c. glabra ...200515673726
susceptibilities to amphotericin b and fluconazole of candida species in taiwan surveillance of antimicrobial resistance of yeasts 2006.susceptibilities to amphotericin b and fluconazole of 964 candida isolates collected in taiwan surveillance of antimicrobial resistance of yeasts in 2006 were determined. there were 419 (43.5%) candida albicans, 246 (25.5%) candida tropicalis, 211 (21.9%) candida glabrata, 62 (6.4%) candida parapsilosis, 14 (1.5%) candida krusei, and 12 (1.2%) others. interestingly, 16 of the 17 amphotericin b-resistant isolates were non-albicans candida species. the resistant rate to amphotericin b has decrease ...200818304773
species distribution and fluconazole susceptibility of candida clinical isolates in a medical center in 2002.fluconazole disk-diffusion susceptibility was evaluated in 230 blood isolates and 344 non-blood clinical isolates of candida spp. collected in 2002 at national taiwan university hospital. up to 93.5% of blood isolates were susceptible to fluconazole, 3% were susceptible dose-dependent, and 3.5% were resistant. the minimum inhibitory concentrations at which 50% of tested isolates were inhibited (mic50) of fluconazole against candida blood isolates were highest for candida glabrata (5 microg/ml), ...200415340652
clinical characteristics, treatment and prognostic factors of candidal meningitis in a teaching hospital in taiwan.the prognostic factors of candidal meningitis had rarely been studied owing to the rarity of this disease. we identified 17 patients with candidal meningitis at a teaching hospital in taiwan over a 14-y period and give details of the clinical features, treatment, outcome and prognostic factors of this disease. 10 patients were children (1 was neonate) and 7 were adults. the clinical features and cerebrospinal fluid (csf) findings were non-specific. the disease was diagnosed > 72 h after hospital ...200415061667
fluconazole resistance rate of candida species from different regions and hospital types in taiwan.from april 15 to june 15, 1999, 581 clinical candida isolates from 19 hospitals in taiwan were collected and susceptibilities to fluconazole of these isolates were determined by a broth microdilution method. a total of 42 (7.2%) isolates were resistant to fluconazole. isolates from medical centers had a higher resistance rate to fluconazole than those from regional hospitals (10.7% vs 4.9%). candida species isolated from different regions had different degrees of susceptibility to fluconazole. a ...200314582563
stable susceptibility of candida blood isolates to fluconazole despite increasing use during the past 10 years.the prevalence of drug-resistant bacterial pathogens is very high in taiwan. accordingly, there was great concern that the introduction of fluconazole would result in rapid emergence of drug-resistant yeasts. thus, we recommended in 1991 that fluconazole be used for treatment only. to explore the impact of this policy fluconazole susceptibility of candida species blood culture isolates and outcome of patients with nosocomial candidaemia were monitored prospectively at national taiwan university ...200312775680
predominance of gram-negative bacilli and increasing antimicrobial resistance in nosocomial bloodstream infections at a university hospital in southern taiwan, 1996-2003.while nosocomial infections cause substantial morbidity and mortality, the availability of timely and accurate epidemiological information on nosocomial pathogens is essential to the appropriate selection of empirical therapy. this study analyzed nosocomial bloodstream infections (nbsis) surveillance data to determine trends in the distribution of pathogens and antimicrobial susceptibilities of these pathogens.200616604246
fungal empyema thoracis: an emerging clinical entity.to analyze the clinical spectra, pathogenesis, treatment, outcome, and prognostic factors of fungal empyema thoracis.200010858401
risk factors for candidemia-related mortality at a medical center in central taiwan.bloodstream infections due to candida spp. are associated with significant mortality and morbidity. this study analysed the epidemiology and outcome of candidemia cases in a teaching hospital in central taiwan.200616604249
genotyping analysis of colonizing candidal isolates from very-low-birthweight infants in a neonatal intensive care unit.to analyse the relatedness of colonizing candidal isolates from very-low-birthweight infants hospitalized in a neonatal intensive care unit (nicu), we prospectively collected 86 candidal isolates from 20 infants, including 67 isolates of candida albicans from 15 infants, 17 isolates of candida parapsilosis from five infants and two isolates of candida glabrata from one infant, who also had c. albicans colonization, over a one-year period. all 86 isolates were genotyped by infrequent-restriction- ...200415501334
[secular trends in the etiology of nosocomial infection at a teaching hospital in taiwan, 1981-1994].surveillance system of nosocomial infection was established in 1980 at the national taiwan university hospital (ntuh). to identify pathogens and the secular trends in the etiology of nosocomial infection from 1981 to 1994, the prospective, hospital-wide nosocomial surveillance data were analysed. during this period, 22,146 pathogens causing nosocomial infections were isolated. gram-negative aerobic bacteria remained the major pathogens, but gram-positive cocci and fungi increased rapidly in the ...19959774999
composition and antimicrobial activity of the leaf essential oil of litsea kostermansii from taiwan.the hydrodistillated leaf essential oil of litsea kostermansii was analyzed to determine its composition and yield. seventy-three compounds were identified, the main components being beta-eudesmol (22.5%), gamma-eudesmol (18.6%), delta-selinene (8.5%), alpha-eudesmol (6.0%), and gamma-muurolene (4.7%). oxygenated sesquiterpenes (66.2%) and sesquiterpene hydrocarbons (32.8%) were the predominant groups of compounds. the leaf oil exhibited excellent antimicrobial activities.200919768997
hepatosplenic fungal infection in patients with acute leukemia in taiwan: incidence, treatment, and prognosis.nosocomial fungal infection increases gradually and has become the leading pathogen at national taiwan university hospital since 1993. from january 1995 through may 2002, hepatosplenic fungal infection (hsf) was diagnosed in 37 (7.4%) of the 500 adult patients with acute leukemia who received chemotherapy at this hospital. there was no significant difference in the incidence of hsf between the patients with acute myeloid leukemia and those with acute lymphoblastic leukemia, or between the patien ...200312601487
invasive candidiasis: an overview from taiwan.invasive candidiasis has emerged as an important nosocomial infection, especially in critically ill patients. we review the epidemiology of invasive candidiasis with an emphasis on data from taiwan. an increasing incidence of candidemia became apparent from 1980 to the end of the 1990s, followed by relative stability. crude mortality rates of patients with candidemia were in the range of 35% to 60%. candida albicans remains the predominant cause of invasive candidiasis in taiwan and accounts for ...200919515624
effect of overnight storage of blood culture bottles on bacterial detection time in the bactec 9240 blood culture system.identifying the pathogens present in blood stream infections is crucial to initiate appropriate antimicrobial therapy and avoid morbidity and mortality. the aim of this study was to evaluate the effect of overnight storage of aerobic and anaerobic bactec 9240 blood culture bottles on the detection time for common pathogens.201020457429
secular trends of healthcare-associated infections at a teaching hospital in taiwan, 1981-2007.the national taiwan university hospital (ntuh) adopted international guidelines for surveillance and control of healthcare-associated infection (hcai) in 1981. this report describes the secular trends in hcai at the ntuh over the past 27 years according to site of infection, aetiological agents and control measures. clinical and microbiological data were collected by infection prevention and control nurses using a standardised case-record form. specific control programmes were implemented and/or ...201020663585
role of pollen allergy in taiwanese patients with allergic rhinitis.pollen allergy is believed to be less common in east asia, latin america, and tropical areas. the purpose of this study was to understand the role of pollen allergy in taiwan.201021195885
molecular epidemiology and antifungal susceptibility of candida parapsilosis sensu stricto, candida orthopsilosis, and candida metapsilosis in taiwan.candida parapsilosis was recently reclassified into 3 closely related species, c. parapsilosis sensu stricto, candida orthopsilosis, and candida metapsilosis. variation in susceptibility characteristics and prevalence of the 3 genomic species could have therapeutic and epidemiologic implications. the aim of this study is to characterize the genetic and antifungal susceptibility profiles of 97 c. parapsilosis isolates from 71 patients. among the 71 nonduplicate isolates, 85.9% (61/71) were identi ...201020851551
candida glabrata fungaemia in a tertiary centre in taiwan: antifungal susceptibility and outcomes.the proportion of non-albicans candidaemia has increased during recent decades, especially candida glabrata. we evaluated the antifungal susceptibility, clinical features and outcome of c. glabrata fungaemia treated in a tertiary centre in taiwan. all episodes of c. glabrata fungaemia during 1999-2005 were identified from microbiology laboratory records and all c. glabrata isolates were subjected to antifungal susceptibility testing by the broth microdilution method. a total of 177 episodes of c ...200919361960
outbreak of candida albicans fungaemia in a neonatal intensive care unit.during a 4-month period, 9 premature infants hospitalized in a neonatal intensive care unit (nicu) developed candida albicans fungaemia. all 9 infants received antifungal agents. fluconazole was administered in 7 patients and successfully eradicated this organism in 6 with no adverse effects. for epidemiological investigation, 64 environmental specimens and hand-washings of all 54 staff members involved in the nicu were examined for the presence of this organism. no c. albicans could be identifi ...19989730299
comparison of four molecular typing methods to assess genetic relatedness of candida albicans clinical isolates in taiwan.this report describes the investigation of the genetic profiles of 53 candida albicans isolates collected from 18 hospitals in taiwan using three pfge-based typing methods (pfge karyotyping, and pfge of sfii and bsshii restriction fragments) and one repetitive-sequence-pcr (rep-pcr) method. all four methods were able to identify clonal related isolates from the same patients. pfge-bsshii exhibited the highest discriminatory power by discriminating 40 genotypes, followed by pfge-sfii (35 genotype ...200515713608
pediatric nosocomial fungal infections.during a period of twelve years (1984-1995), ninety-seven pediatric patients experienced 107 nosocomial fungal infections at mackay memorial hospital. the nosocomial fungal infection rate in pediatric patients was lower than that of the hospital as whole, but it increased significantly. the average rate in the last three years (1993-1995) was 1.20 per thousand discharged patients, 10 times that of the first three years (1984-1986). two-thirds of the patients were below one year of age. half of t ...19979322304
the distribution and drug susceptibilities of clinical candida species in tsary 2014.the species distribution and drug susceptibilities of 1106 candida isolates collected in taiwan surveillance of antimicrobial resistance of yeasts (tsary) in 2014 were determined. candida albicans is still the dominant species, accounting for 35.9%, followed by 28.3% c. glabrata, 26.6% c. tropicalis, 5.2% c. parapsilosis, 1.0% c. krusei, and 3.0% of 13 other species. interestingly, the prevalence of candidemia caused by c. glabrata in the present study is significantly higher than that in previo ...201627717650
the isolation and structural characterization of 5-o-methyldesmethoxymatteucinof from eugenia javanica. 19734589735
molecular epidemiology of invasive candida albicans at a tertiary hospital in northern taiwan from 2003 to 2011.candida albicans is a common cause of bloodstream fungal infections in hospitalized patients. to investigate its epidemiology, multilocus sequence typing (mlst) was performed on 285 c. albicans bloodstream isolates from patients in chang gung memorial hospital at linkou (cgmhl), taiwan from 2003 to 2011. among these isolates, the three major diploid sequence types (dsts) were 693, 659, and 443 with 19, 16, and 13 isolates, respectively. the 179 dsts were classified into 16 clades by unweighted p ...201526333357
secular trends in the epidemiology of nosocomial fungal infections at a teaching hospital in taiwan, 1981 to 1993.to describe the incidence and patterns of nosocomial fungal infection in a large teaching hospital in taiwan.19979154483
the clinical outcomes and predictive factors for in-hospital mortality in non-neutropenic patients with candidemia.recent epidemiologic studies have showed that candidemia is an important nosocomial infection in hospitalized patients. the majority of candidemia patients were non-neutropenic rather than neutropenic status. the aim of this study was to determine the clinical outcome of non-neutropenic patients with candidemia and to measure the contributing factors for mortality. a total of 163 non-neutropenic patients with candidemia during january 2010 to december 2013 were retrospectively enrolled. the pati ...201627281087
antifungal susceptibility of candida species isolated from patients with candidemia in southern taiwan, 2007-2012: impact of new antifungal breakpoints.the clinical and laboratory standard institute (clsi) revised the clinical breakpoints (cbps) for the azoles and echinocandins against candida species in 2012. we aimed to report the epidemiology of candidemia and antifungal susceptibility of candida species and evaluate the impact of new cbps on antifungal susceptibility in our region. all blood isolates of candida species were obtained from 2007 to 2012. the minimum inhibitory concentrations of fluconazole, voriconazole, echinocandins and fluc ...201727621210
long-term characteristics of healthcare-associated infections in a neonatal intensive care unit.healthcare-associated infections in neonatal intensive care units (nicus) are associated with a significant risk of morbidity and mortality. knowledge regarding pathogens, primary sources of infection and antibiotic resistance in the nicu is essential for developing management strategies. this study aimed to analyze the long-term characteristics of healthcare-associated infections in a tertiary referral center in southern taiwan.201021075708
prognostic factors for patients with culture-positive candida infection undergoing abdominal surgery.increased risk for fungal infections has been observed in high-risk surgical patients, but the prognostic factors and impact of antifungal agents in this patient population are uncertain, especially in patients undergoing abdominal operation. this study was performed to ascertain the prognostic factors for patients with culture-positive candida spp. who have had abdominal surgery.200920182666
candida empyema thoracis at a hospital in taiwan.we conducted a study of the clinical manifestations and outcomes of empyema thoracis caused by candida spp. in hospitalized patients.201424841623
yeast oropharyngeal colonization in human immunodeficiency virus-infected patients in central taiwan.a prospective, cross-sectional study was conducted at a medical center in central taiwan to understand the prevalence, associated factors, and microbiologic features for oropharyngeal yeast colonization in human immunodeficiency virus-infected outpatients. oral yeast colonization was detected in 127 (45 %) patients, including 21 (16.5 %) colonized by more than one species. of the 154 isolates, candida albicans was the most common species (114, 74 %), followed by candida dubliniensis (10, 6.5 %), ...201424804977
composition and antimicrobial activity of the leaf and twig oils of litsea mushaensis and l. linii from taiwan.the hydrodistilled essential oils of the leaves and twigs of litsea mushaensis and l. linii were analyzed. sixty-nine and ninety compounds were identified in the leaf and twig oils, respectively, of l. mushaensis. the main components of the leaf oil were beta-eudesmol (24.2%), tau-cadinol (10.2%), alpha-humulene (10.1%), alpha-pinene (9.7%), and trans-beta-ocimene (6.5%), whereas the main components of the twig oil were trans-beta-ocimene (19.5%), alpha-pinene (12.8%) and cis-beta-ocimene (7.7%) ...201021213991
antimicrobial activity of isoquinoline alkaloids and their n-oxide derivatives. 19883043007
clinical and molecular characteristics of bloodstream infections caused by candida albicans in children from 2003 to 2011.we investigated the clinical and molecular characteristics of candida albicans bloodstream infection (bsi) in children from a tertiary-level medical centre in taiwan over a 9-year period from january 2003 to december 2011. we performed multilocus sequence typing (mlst) to investigate the genetic relatedness of these c. albicans bsi isolates. a total of 79 episodes of c. albicans bsi in 76 paediatric patients were identified, including 41 (51.9%) from the paediatric intensive care unit, 24 (30.4% ...201526148466
changes in the incidence of candidaemia during 2000-2008 in a tertiary medical centre in northern taiwan.candidaemia is associated with high mortality and high healthcare costs. the incidence of candidaemia in taiwan rose markedly during the period 1980-2000. we conducted this hospital-based surveillance study in order to explore the secular trend in incidence of candidaemia during the period 2000 to 2008. in our study, candida spp. were the fourth most common cause of bloodstream infections, with a 30-day crude mortality rate of 36.7%. candida albicans was the most common species identified, altho ...201121316800
characterization of yeasts colonizing in healthy individuals.opportunistic yeast pathogens may switch from harmless commensal to pathogenic relationships with the host under different conditions. they usually cause superficial infections, but may be the agents of more significant infections in immunocompromised patients. to investigate yeast colonization in the oral cavities of clinically healthy individuals, we collected oral swabs from 323 students and staff at the national health research institutes, taiwan. a total of 49 (15.2%) volunteers were coloni ...201120491531
antimicrobial susceptibility and clinical outcomes of candida parapsilosis bloodstream infections in a tertiary teaching hospital in northern taiwan.candida parapsilosis is an emerging non-albicans candida that is associated with central line-associated infection. c. parapsilosis has higher minimal inhibitory concentration to echinocandin than candida albicans, and the effects of echinocandin on c. parapsilosis are ambiguous. therefore, in this study, we aimed to investigate the susceptibility and the correlation between incidence and drug consumption.201525315213
composition and antimicrobial activities of the leaf essential oil of machilus kusanoi from taiwan.the hydrodistillated leaf essential oil of machilus kusanoi was analyzed to determine its composition and yield. twenty-three compounds were identified, the main components being beta-caryophyllene (23.3%), beta-eudesmol (17.1%), alpha-terpineol (16.0%), n-dodecanal (14.2%), and n-decanal (10.4%). sesquiterpene hydrocarbons (28.1%) and non-terpenoids (25.0%) were the predominant groups of compounds. the leaf oil exhibited excellent antimicrobial and anti-wood-decay fungal activities.201121425691
composition, in vitro cytotoxic, and antimicrobial activities of the flower essential oil of diospyros discolor from taiwan.this study investigated the chemical composition, in vitro cytotoxic, and antimicrobial activities of the essential oil isolated from the flower of diospyros discolor from taiwan. the essential oil was isolated using hydrodistillation in a clevenger-type apparatus, and characterized by gc-fid and gc-ms. twenty-eight compounds were identified, representing 100% of the oil. the main components identified were (2z,6e)-farnesol (35.0%), α-cadinol (10.9%), (e)-nerolidol (6.9%), α-humulene (6.0%), τ-c ...201526411038
changing epidemiology of candidemia in a medical center in middle taiwan.candidemia remains a major cause of morbidity and mortality in the health care setting, and the epidemiology of candida infection is changing.201524113067
epidemiology and prognostic factors of candidemia in elderly patients.the present retrospective study was carried out to investigate the epidemiological characteristics and the prognostic factors of candidemia among elderly patients.201525256556
antifungal susceptibilities of candida isolates causing bloodstream infections at a medical center in taiwan, 2009-2010.we used the sensititre yeastone (syo) method (trek diagnostic systems) to determine the mics of nine antifungal agents against 474 nonduplicate blood candida isolates. the mic results were interpreted according to updated clinical breakpoints (cbps) recommended by the clinical and laboratory standards institute (clsi; document m27-s4) or epidemiology cutoff values (ecvs). the rates of fluconazole susceptibility were 99.2% (234/236) in candida albicans, 86.7% (85/98) in c. tropicalis, and 97.7% ( ...201424752274
report of a 63-case series of candida empyema thoracis: 9-year experience of two medical centers in central taiwan.candida empyema thoracis is a serious complication of invasive candidiasis with high mortality. however, the treatment for candida empyema remains controversial. we conducted a 9-year retrospective study to analyze the treatments and factors associated with the mortality of patients with candida empyema thoracis in two medical centers in central taiwan.201423102708
clinical characteristics of candidaemia in adults with haematological malignancy, and antimicrobial susceptibilities of the isolates at a medical centre in taiwan, 2001-2010.during the period 2001-2010, a total of 154 episodes of candidaemia were noted in 111 of 2574 patients with haematological malignancies at the national taiwan university hospital (taipei, taiwan). patients with acute lymphoblastic leukaemia had a significantly higher rate of candidaemia than patients with other haematological malignancies (odds ratio=2.69; p<0.001). candida tropicalis was the most common candida species (n=51; 46%), followed by candida albicans (n=35; 32%), candida parapsilosis ...201223006521
association between incidence of candidaemia and consumption of antifungal agents at a medical centre in taiwan.this study investigated the correlations between consumption of antifungal agents and species distribution in candidaemia. the incidence of patients with community-acquired candidaemia (cac) (per 1000 admissions) and healthcare-associated candidaemia (hcac) (per 1000 admissions) as well as data on annual consumption [defined daily doses (ddd)/1000 patient-days] of various antifungal agents at a medical centre in taiwan from 2000 to 2010 were evaluated. a total of 2682 episodes of candidaemia wer ...201222819796
pharmacoeconomic analysis of antifungal therapy for primary treatment of invasive candidiasis caused by candida albicans and non-albicans candida species.cost-effectiveness studies of echinocandins for the treatment of invasive candidiasis, including candidemia, are rare in asia. no study has determined whether echinocandins are cost-effective for both candida albicans and non-albicans candida species. there have been no economic evaluations that compare non-echinocandins with the three available echinocandins. this study was aimed to assess the cost-effectiveness of individual echinocandins, namely caspofungin, micafungin, and anidulafungin, ver ...201728693479
clinical significance of time to positivity for yeast in candidemia.candidemia is an important issue of nosocomial bloodstream infections, and is associated with a high mortality rate. however, little information is available before final species identification, which takes days after the episode of candidemia. this study tried to determine whether time to positivity (ttp) for yeast helps in predicting the species of candidemia.201524388580
the impact of oral herpes simplex virus infection and candidiasis on chemotherapy-induced oral mucositis among patients with hematological malignancies.the aim of this study was to evaluate the influences of oral candidiasis and herpes simplex virus 1 (hsv-1) infections in chemotherapy-induced oral mucositis (om). the medical records of 424 consecutive patients with hematological malignancies who had received chemotherapy at a medical center in taiwan from january 2006 to november 2007 were retrospectively reviewed. the results of swab cultures of fungus and hsv-1 for om were correlated with associated clinical features. younger age, myeloid ma ...201121225303
candida albicans versus non-albicans bloodstream infections: the comparison of risk factors and outcome.background: candidemia caused by non-albicans candida spp. is of special concern because of its high drug resistance and increase in prevalence. in clinical practice, early identification of non-albicans candidemia is crucial. we investigated the outcome in patients with candidemia caused by candida albicans and candida non-albicans. methods: we retrospectively evaluated candidemic patients from october 2007 to july 2009. underlying diseases, predisposing factors, laboratory data, and outcome we ...201121524971
oropharyngeal yeast colonization in hiv-infected outpatients in southern taiwan: cd4 count, efavirenz therapy and intravenous drug use matter.clin microbiol infect abstract: to understand the status of oropharyngeal yeast colonization in human immunodeficiency virus (hiv) -infected outpatients in the era of highly active antiretroviral therapy (haart), we conducted a prospective, cross-sectional study from october 2009 to january 2010 at a medical centre in southern taiwan. fungal cultures of the oropharyngeal swabs were performed on 327 enrolled patients. at enrolment, 258 (79%) patients had been receiving haart, and 42 (12.8%), 73 ( ...201121939471
an emerging issue of mixed yeast cultures.different yeast species have different susceptibilities to commonly prescribed antifungal drugs. thus, it is important to accurately determine the species of pathogenic yeasts, especially when more than one species are in a specimen.201423523053
characterization of candida species from different populations in taiwan.the opportunistic candida species existing as part of commensal microbiota in humans are usually the etiological agents causing infections. we investigated whether isolates collected from different age groups, hospital units, and sources have distinct characteristics. a total of 913 isolates comprising 395 candida albicans, 230 candida tropicalis, 202 candida glabrata, 62 candida parapsilosis, 13 candida krusei, and 11 of other six species were analyzed. urine was the most common source (41.2%), ...201121369746
distribution and drug susceptibilities of candida species causing candidemia from a medical center in central taiwan.invasive fungal infections have increased significantly in the past few decades because of the increase in high-risk populations. to investigate the distribution and drug susceptibilities of such infections, we analyzed all 152 candida isolates causing candidemia from 2004 to 2006 at the china medical university hospital, a medical center in central taiwan. candida albicans was the most common species, accounting for 52.6% of the isolates, followed by c. tropicalis (19.7%), c. parapsilosis (14.5 ...201323732308
catheter-related fungemia caused by candida dubliniensis.infections caused by candida dubliniensis in humans are rare and have never been reported in taiwan. we report two cancer patients with catheter-related fungemia due to c. dubliniensis infection in taiwan. the two isolates were confirmed to the species level using an oligonucleotide array system and sequence analysis, and both showed high in vitro susceptibilities to nine antifungal agents. the catheters were removed, and both patients responded well to antifungal treatment. although this type o ...201323246304
human pathogenic fungi in china-emerging trends from ongoing national survey for 1986, 1996, and 2006.this epidemiological survey was a retrospective study on three nodes during the past three decades on fungal infections representing the china, including taiwan. owing to rare publications reporting on dynamic epidemiological trends in the pathogen epidemiology in china, we surveyed the isolation rates and pathogenic fungi from 8 representative districts in china using uniform identification with uniform methodology. the pathogenic fungi isolation rates and species obtained from 1986 (n = 9,096) ...201121509517
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