Publications

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antineoplastic agents. 554. the manitoba bacterium streptomyces sp.a streptomyces sp. isolated from riverbank soil in manitoba, canada, was found to contain two cancer cell growth inhibitories: diazaanthraquinone 1 and 3-(hydroxyacetyl)indole (8). the structures were determined by interpretation of data from hrms, uv, and high-field (400 mhz) nmr experiments. the red-colored diazaanthraquinone 1 and 3-(hydroxyacetyl)indole (8) were found to inhibit (0.1-3 microg/ml) growth of a minipanel of human cancer cell lines and p388 lymphocytic leukemia cells. diazaanthr ...200616724845
susceptibility of n. gonorrhoeae to antibiotics: a study of 200 consecutive strains isolated in winnipeg in 1962.gonorrhea has increased in incidence over the past five years in manitoba as elsewhere. cases which did not respond to routine penicillin treatment were noted to be occuring more often. in 1948, strains of n. gonorrhoeae isolated in canada were all sensitive to 0.06 unit of penicillin per c.c. in vitro. commencing in may 1962, strains of n. gonorrhoeae were isolated from 100 patients of each sex attending the clinic at the st. boniface general hospital. eighteen per cent required concentrations ...196314063939
sexually transmitted diseases in manitoba: evaluation of physician treatment practices, std drug utilization, and compliance with screening and treatment guidelines.there is little information in manitoba on the utilization of drugs for sexually transmitted disease (std) treatment and the extent to which physicians comply with std screening and treatment guidelines. this study was undertaken to provide such information to inform policy and program development.200212466729
risk factors for infection in women undergoing testing for chlamydia trachomatis and neisseria gonorrhoeae in manitoba, canada.despite sharing common modes of transmission, characteristics of individuals infected with chlamydia trachomatis differ in several respects from those with neisseria gonorrhoeae infection. further characterization of women at high risk for chlamydial infection is needed to deliver appropriate and effective preventive, diagnostic, and therapeutic care to this population.19957502182
comparison of three serological tests in gonococcal infection.three serological tests used in the diagnosis of gonococcal infection were compared with cultural techniques in 857 females attending the prenatal and gynaecology clinics at the winnipeg general hospital. the tests evaluated were the microflocculation technique (mft), the indirect fluorescent-antibody technique (ifat), and the complement-fixation technique (cft). one hundred six patients had positive cultures for neisseria gonorrhoeae. in this population, the mft was reactive in 80 patients (75. ...19744596750
outbreak of penicillin- and tetracycline-resistant neisseria gonorrhoeae in manitoba in 1991. 19921291008
pediatric gonococcal infection: case report demonstrating diagnostic problems in remote populations.the inability of neisseria gonorrhoeae to survive prolonged transit times and hostile ambient temperatures has made its detection at referral laboratories by cultural methods untenable. in this situation, reliance upon antigen detection systems is attractive but when these tests are performed on vaginal specimens from children, false positive results are a significant concern. some of the difficulties associated with the investigation of a gonococcal infection resulting from sexual abuse of a ch ...19957780787
prevalence of and risk factors for quinolone-resistant neisseria gonorrhoeae infection in ontario.quinolone-resistant neisseria gonorrhoeae has swiftly emerged in canada. we sought to determine its prevalence in the province of ontario and to investigate risk factors for quinolone-resistant n. gonorrhoeae infection in a canadian setting.200919188626
interpretation of laboratory detection trends for chlamydia trachomatis and neisseria gonorrhoeae: manitoba, canada, 2000-2012.increases in case numbers for chlamydia trachomatis (ct) and neisseria gonorrhoeae (ng) have been noted on a global level. this study analysed 13 years of testing data to better understand case detection trends over time.201625969541
vaginal microbial flora as a cofactor in the pathogenesis of uterine cervical intraepithelial neoplasia.the vaginal microbial flora of 106 women with histopathologically confirmed cervical intraepithelial neoplasia and 79 women without disease, was evaluated for gardnerella vaginalis, trichomonas vaginalis, candida albicans and other yeasts. flora morphology was assessed by gram staining of secretions. cervical cultures were examined for herpes simplex virus, cytomegalovirus and neisseria gonorrhoeae. chlamydia trachomatis antigens in cervical secretions were detected by enzyme immunoassay. human ...19921351005
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