Publications

TitleAbstractYear
Filter
PMID
Filter
comparison of fecal occult blood tests for colorectal cancer screening in an alaska native population with high prevalence of helicobacter pylori infection, 2008-2012.alaska native colorectal cancer (crc) incidence and mortality rates are the highest of any ethnic/racial group in the united states. crc screening using guaiac-based fecal occult blood tests (gfobt) are not recommended for alaska native people because of false-positive results associated with a high prevalence of helicobacter pylori-associated hemorrhagic gastritis. this study evaluated whether the newer immunochemical fobt (ifobt) resulted in a lower false-positive rate and higher specificity f ...201424721216
helicobacter pylori, anemia, and iron deficiency: relationships explored among alaska native children.attempts to understand determinants of anemia and iron deficiency have led researchers to examine the role of helicobacter pylori infection. the current study assessed determinants of anemia and iron deficiency, including h. pylori, in alaska native children.200717901799
alaska sentinel surveillance for antimicrobial resistance in helicobacter pylori isolates from alaska native persons, 1999-2003.previous studies in alaska have demonstrated elevated proportions of antimicrobial resistance among helicobacter pylori isolates.200617083381
reinfection after successful eradication of helicobacter pylori in three different populations in alaska.we performed a study to determine rates of reinfection in three groups followed for 2 years after successful treatment: american indian/alaska native (ai/an) persons living in urban (group 1) and rural (group 2) communities, and urban alaska non-native persons (group 3). we enrolled adults diagnosed with h. pylori infection based on a positive urea breath test (13c-ubt). after successful treatment was documented at 2 months, we tested each patient by 13c-ubt at 4, 6, 12 and 24 months. at each vi ...201525068917
helicobacter pylori infection and markers of gastric cancer risk in alaska native persons: a retrospective case-control study.alaska native persons experience gastric cancer incidence and mortality rates that are three to four times higher than in the general united states population.201424945184
the effect of helicobacter pylori infection on iron stores and iron deficiency in urban alaska native adults.helicobacter pylori (h. pylori) infection has been correlated with low serum ferritin and iron deficiency. as a secondary analysis of a study of h. pylori reinfection, we investigated the association of h. pylori infection and the effect of its eradication on serum ferritin and iron deficiency.201323316928
endemic iron deficiency associated with helicobacter pylori infection among school-aged children in alaska.rural alaska natives have a high prevalence of iron deficiency and helicobacter pylori infection. the objective of this study was to estimate the prevalence of iron deficiency, iron-deficiency anemia, and active h pylori infection among school-aged children in rural alaska.200616452320
prevalence and persistence of antibodies to herpes viruses, chlamydia pneumoniae and helicobacter pylori in alaskan eskimos: the gocadan study.the prevalence and persistence of antibodies against cytomegalovirus (cmv), herpes simplex virus types 1 (hsv1) and 2 (hsv2), helicobacter pylori and chlamydia pneumoniae were determined in alaskan eskimos. the study included 610 individuals (mean age 43 +/- 15 years; 45% males) participating in the genetics of coronary artery disease in alaska natives (gocadan) study. archived serum samples and those collected during the gocadan study were analysed for antibodies against the above pathogens by ...200616441448
reinfection after successful eradication of helicobacter pylori: a 2-year prospective study in alaska natives.limited information exists regarding risk factors for reinfection after cure of helicobacter pylori infection.200616611283
asymptomatic helicobacter pylori infection and iron deficiency are not associated with decreased growth among alaska native children aged 7-11 years.alaska native children have high helicobacter pylori infection and iron deficiency prevalences, and their average height-for-age is lower than us reference populations. during a clinical trial to determine the impact of h. pylori treatment on iron deficiency, we evaluated the effects of h. pylori infection and treatment on growth.200616684263
dynamics of helicobacter pylori-specific immunoglobulin g for 2 years after successful eradication of helicobacter pylori infection in an american indian and alaska native population.helicobacter pylori antibodies were measured over 24 months in american indian and alaska native persons who cleared their infections. two months after treatment, 82% of h. pylori-negative persons remained seropositive. while there were declines in h. pylori antibodies for 12 months, after 24 months 71% of persons remained seropositive.200717079433
community well being and infectious diseases among alaska native communities in the chugach region.this study sought to examine how native people of the chugach region of alaska perceive their own communities' health and well being, particularly in regard to infectious diseases.200111768448
high prevalence of helicobacter pylori in the alaska native population and association with low serum ferritin levels in young adults.iron deficiency anemia is a common public health problem in the alaska native population. yet, a clear etiology has eluded researchers for decades. previous studies suggested a link between helicobacter pylori infection, gastrointestinal blood loss due to hemorrhagic gastritis, and generalized iron deficiency anemia in adult alaska natives. therefore, we examined the association between the prevalence of h. pylori-specific immunoglobulin g (igg) and serum ferritin levels, a marker of iron defici ...200011063492
emerging infectious diseases in alaska and the arctic: a review and a strategy for the 21st century.emergence of new, previously unknown, and drug-resistant infectious diseases pose a major threat to global health. the emergence of infectious diseases in alaska and the arctic parallels the resurgence of infectious diseases worldwide. the centers for disease control and prevention has developed a strategy to revitalize the capacity to protect the public from emerging infectious diseases by improving four major public health activities: surveillance and response, applied research, infrastructure ...199910434444
pervasive occult gastrointestinal bleeding in an alaska native population with prevalent iron deficiency. role of helicobacter pylori gastritis.to confirm prevalent iron deficiency among yupik eskimos living in alaska and to explore the frequency of and potential lesions accounting for occult gastrointestinal bleeding.19979087468
geographic and racial patterns of anemia prevalence among low-income alaskan children and pregnant or postpartum women limit potential etiologies.the etiology of the 10-fold increase in anemia and iron deficiency prevalence among alaska native individuals from the culturally traditional southwestern/northern alaska regions remains unknown. the present study sought to determine anemia prevalence among people enrolled in the alaska women, infant, and children (wic) program and reconcile results with etiological hypotheses, particularly nutritional iron deficiency and helicobacter pylori infection.200919322058
gastric cancer among american indians and alaska natives in the united states, 1999-2004.gastric cancer incidence rates for american indians and alaska natives (ai/ans) historically have exceeded those for non-hispanic whites (nhws). previous reports may have underestimated the true burden of gastric cancer in ai/an populations because of misclassification of ai/an race in cancer registries.200818720378
Diagnostic accuracy of tests for Helicobacter pylori in an Alaska Native population.To evaluate the accuracy of two non-invasive tests in a population of Alaska Native persons. High rates of Helicobacter pylori (H. pylori) infection, H. pylori treatment failure, and gastric cancer in this population necessitate documentation of infection status at multiple time points over a patient's life.201122180710
a controlled, household-randomized, open-label trial of the effect that treatment of helicobacter pylori infection has on iron deficiency in children in rural alaska.helicobacter pylori infection and iron deficiency are prevalent in disadvantaged populations worldwide. previous small or uncontrolled studies have reported that successful treatment of h. pylori infection may resolve iron deficiency or anemia.200616425133
a prospective evaluation of 200 upper endoscopies performed in alaska native persons.to characterize the nature and prevalence of disease in alaska native patients referred for evaluation of upper gastrointestinal signs and symptoms.200717515254
helicobacter pylori infection among non-native educators in alaska.to determine seroprevalence of h. pylori infection in non-native educators residing in urban or rural settings in alaska, and to determine potential risk factors associated with infection in this population.200717515253
does delayed testing of urea breath test samples effect results? 200516024932
controlled, household-randomized, open-label trial of the effect of treatment of helicobacter pylori infection on iron deficiency among children in rural alaska: results at 40 months.helicobacter pylori infection treatment was found not to reduce the prevalence of iron deficiency or anemia among alaska native children at 14 months after treatment initiation. we hypothesized that 14 months was to early to resolve h. pylori-induced gastric damage. consequently, we conducted a 40-month follow-up.200919125674
epidemiology of hospitalizations associated with ulcers, gastric cancers, and helicobacter pylori infection among american indian and alaska native persons.to describe the epidemiology of ulcers, gastric cancer, and helicobacter pylori infection among american indian (ai) and alaska native (an) persons, we analyzed hospitalization discharge records with physician discharge diagnoses coded as ulcer, gastric cancer, and mucosa-associated lymphoid tissue (malt) lymphoma during 1980 to 2005, and h. pylori during 1996 to 2005 from the indian health service inpatient dataset. the average annual age-adjusted rate of hospitalizations that included an ulcer ...200818458318
alaska sentinel surveillance study of helicobacter pylori isolates in alaska native persons from 2000-2008.background: helicobacter pylori (h. pylori) infection is more common in alaska native persons than the general us population, with seroprevalence to h. pylori approaching 75%. previous studies in alaska have demonstrated elevated proportions of antimicrobial resistance among h. pylori isolates. we analyzed h. pylori data from the centers for disease control and prevention's sentinel surveillance in alaska from january 2000-december 2008 to determine the proportion of culture-positive biopsies wi ...201121813726
characterization of helicobacter pylori caga and vaca genotypes among alaskans and their correlation with clinical disease.background: helicobacter pylori (h. pylori) infection is common in alaska. development of severe h. pylori disease is partially determined by virulence of the infecting strain. here we present vaca and caga genotype data from h. pylori isolated from alaskans and their correlation with clinical disease. methods: we enrolled patients scheduled for esophagogastroduodenoscopy and positive for a h. pylori infection. gastric biopsies from the stomach antrum and fundus were cultured. we performed pcr a ...201121752979
statistical genetic analysis of serological measures of common, chronic infections in alaska native participants in the gocadan study.this paper describes genetic investigations of seroreactivity to five common infectious pathogens in the genetics of coronary artery disease in alaska natives (gocadan) study. antibody titers and seroprevalence were available for 495 to 782 (depending on the phenotype) family members at two time points, approximately 15 years apart, for chlamydophila pneumoniae, helicobacter pylori, cytomegalovirus (cmv), herpes simplex virus 1 (hsv-1), and herpes simplex virus 2 (hsv-2). seroprevalence rates in ...201323798484
Displaying items 1 - 27 of 27