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[helicobacter pylori and gastric cancer].several unresolved issues still cast doubts on the epidemiological data which point to an association between infection from helicobacter pylori (hp) and gastric cancer. these are: a) the male/female ratio of gastric cancer ranges from 4 to 1.5 in all studies, whereas the prevalence of hp infection is the same in both sexes; b) the prevalence of hp infection is as high as 90% in several developing countries where the frequency of gastric cancer is very low; c) the acquisition of the infection at ...199910528435
ongoing somatic mutations and clonal expansions after cure of helicobacter pylori infection in gastric mucosa-associated lymphoid tissue b-cell lymphoma.although most patients with primary gastric low-grade mucosa-associated lymphoid tissue (malt) b-cell lymphoma experience complete endoscopic and histologic remission after the cure of helicobacter pylori infection, in many patients, the polymerase chain reaction (pcr) still detects monoclonal b cells in the gastric mucosa. the present study asked whether the lymphoma immunoglobulin vh (igvh) sequences remained stable in patients with gastric malt lymphoma after h pylori eradication.19989850027
prevalence and demographic determinants of metronidazole resistance by helicobacter pylori in a large cosmopolitan cohort of australian dyspeptic patients.the pre-treatment sensitivity of helicobacter pylori to metronidazole is a key determinant of successful eradication therapy and should influence local choice of therapy. however, there are few data defining the prevalence of metronidazole resistance (mr) in australia.19989847953
[gastritis c, non-a non-b and the sydney system: european unification or tower of babel?].the isolation of helicobacter pylori from the human stomach has changed the insights into the mechanisms of chronic gastritis. the altered concepts are reflected in newly developed classification systems. in 1989 distinction of the types a, b and c of chronic gastritis was proposed as a working formulation. in this classification type a gastritis is an autoimmune disease with antibodies against parietal cells and intrinsic factor. it is limited to the body of the stomach and may be complicated b ...19912030784
metronidazole- and clarithromycin-resistant helicobacter pylori in dyspeptic patients in western sydney as determined by testing multiple isolates from different gastric sites.it is unknown whether antibiotic susceptibility testing of antral isolates alone is representative of helicobacter pylori susceptibility. we aimed to determine: (i) the prevalence of metronidazole- and clarithromycin-resistant strains in infected dyspeptic patients; and (ii) whether there is consistency in the susceptibility to metronidazole and clarithromycin among isolates cultured from different gastric sites. antral, body and fundus biopsies were taken from 242 consecutive patients and cultu ...19989835322
prevalence of helicobacter pylori positivity in patients undergoing percutaneous coronary intervention.abstract the adverse effect of haemorrhagic complications after percutaneous coronary intervention (pci) on outcome is well established with h.pylori infection known to be an important precipitant of peptic ulcer disease in patients receiving non-steroidal anti-inflammatory drug therapy. the prevalence of h.pylori positivity in patients undergoing pci and receiving subsequent antiplatelet therapy is unknown. aims: we sought to determine the prevalence and features associated with h. pylori posit ...201020492005
the use of serology to diagnose active campylobacter pylori infection.a serological test that predicts accurately active campylobacter pylori infection in the human stomach has been developed and validated by means of serum from 189 patients who were undergoing endoscopy in sydney. our enzyme-linked immunosorbent assay (elisa) has a sensitivity of 100% and a specificity of 94%. an important part of the test is the inclusion of a simple absorption step with c. jejuni for those sera whose results are close to the cut-off point for positivity. this has been shown to ...19883200186
increased incidence of campylobacter pylori infection in gastroenterologists: further evidence to support person-to-person transmission of c. pylori.the mode transmission of campylobacter pylori is still unknown, although several studies have suggested person-to-person transmission. in this study the incidence of active c. pylori infection in an endoscopy staff was compared with that in general practitioners and normal blood donors. since endoscopy workers are in close contact with patients, many of whom would be likely to have active c. pylori infection, it was likely that there would be an increased incidence of active c. pylori infection ...19892789427
bleeding peptic ulcer: characteristics and outcomes in newcastle, nsw.background peptic ulcer disease risk factors have changed, as has the impact of treatment on morbidity and mortality. recent data on clinical presentation and outcome are sparse in australia. aim to determine the characteristics and outcome of patients presenting with a bleeding peptic ulcer to a tertiary referral centre. methods we evaluated patients diagnosed with peptic ulcer bleeding between 2004 and 2008 at a tertiary referral hospital. variables assessed included demographic data, co-morbi ...201021040320
gastric fundic gland polyps: a clinico-pathological study from north west tasmania.fundic gland polyps (fgps) of the stomach were originally described in association with familial polyposis syndromes. it is now known that the majority of these polyps occur in the sporadic setting and are incidentally seen in up to 1.9% of routine upper gastrointestinal endoscopes. the aim of this study was to look at the clinico-pathological features of the fgps and to analyse their relationship to helicobacter pylori infection, proton pump inhibitor treatment, colonic polyps and malignancy.200919566871
the seroepidemiology of helicobacter pylori infection in australia.infection with helicobacter pylori is common worldwide and a significant cause of upper gastrointestinal disease. prevalence of this infection varies in different population groups internationally. because of the invasiveness of specimen collection for bacteriologic diagnosis and the expense of tests such as labeled urea breath tests, serology is the most feasible means of determining the population epidemiology of h. pylori. the aim of this study was to describe the seroepidemiology of h. pylor ...200818400542
lack of diagnostic accuracy of the monoclonal stool antigen test for detection of helicobacter pylori infection in young australian aboriginal children.: the prevalence of helicobacter pylori infection among aboriginal australians children is unclear. the aims of the present study are to determine the prevalence of h. pylori infection among young aboriginal children recovering from acute diarrheal disease in hospital and to evaluate the h. pylori stool antigen test as a noninvasive diagnostic test in this setting.200919258925
helicobacter pylori eradication: a novel therapeutic option in chronic immune thrombocytopenic purpura.to determine whether helicobacter pylori eradication is an effective treatment for australian patients with chronic immune thrombocytopenic purpura (itp).200818837678
evaluation of anti-helicobacter pylori igg2 antibody for the diagnosis of helicobacter pylori infection in western and chinese populations.the performance of commercial helicobacter pylori diagnostic kits developed for particular geographic regions has often been found to be of poor diagnostic value when applied to other regions, possibly because of infections being caused by different h. pylori strains in different regions.200515644049
helicobacter connections.after preliminary studies in 1981, marshall and warren conducted a study in which the new bacterium helicobacter pylori was cultured. in that series, 100 % of 13 patients with duodenal ulcer were found to be infected. the hypothesis that peptic ulcer was caused by a bacterial infection was not accepted without a fight. most experts believed that helicobacter was a harmless commensal, infecting people who had ulcers for some other reason. in response, marshall drank a culture of helicobacter to p ...200616902931
foetal intrauterine growth restrictions with helicobacter pylori infection.helicobacter pylori infection has been associated with growth restriction in young children.200212197848
association analysis of polymorphisms at the interleukin-1 locus in essential hypertension.infection with microorganisms such as helicobacter pylori and chlamydia pneumoniae has been associated with coronary heart disease (cad) and hypertension (ht). infection increases the release of pro-inflammatory cytokines, thus facilitating interactions that lead to vascular damage and other effects. we hypothesized that genetically determined differences in activity or responsiveness of cytokine(s) might contribute to ht. the interleukin-1 gene (il1) cluster on chromosome 2q14 contains three re ...200211840488
[evaluation of gastric atrophy. comparison between sidney and olga systems].histopathologic identification of atrophy and metaplasia is decisive to stop the way of gastritis?carcinoma in patients with chronic gastritis.200819133183
the profile of health problems in african immigrants attending an infectious disease unit in melbourne, australia.the number of african immigrants living in western countries is increasing. a retrospective audit of sub-saharan african patients attending the infectious diseases clinics of a melbourne teaching hospital was performed. a total of 375 patients were included. helicobacter pylori gastritis was diagnosed in 60% of those tested (35/58), schistosomiasis in 41% (84/206), chronic hepatitis b in 19% (32/167), and strongyloidiasis in 18% (32/179). active tuberculosis (tb) affected 18% (51/276) and latent ...200919407128
reduction of peptic ulcer disease and helicobacter pylori infection but increase of reflux esophagitis in western sydney between 1990 and 1998.we aimed to determine if changes in the patterns of upper gastrointestinal diseases at endoscopy have occurred over the past decade. retrospectively, 917 consecutive patients were selected based on upper endoscopy between june 1 and august 31, in 1990 (n = 217), 1994 (n = 270), and 1998 (n = 430). demographic, clinical, endoscopic, and histological information were extracted from the medical records on a standardized case record form. over the eight-year period, follow-up of peptic ulcer (15%, 5 ...200111768265
screening practices for infectious diseases among burmese refugees in australia.increasing numbers of refugees from burma (myanmar) are resettling in western countries. we performed a retrospective study of 156 burmese refugees at an australian teaching hospital. of those tested, helicobacter pylori infection affected 80%, latent tuberculosis 70%, vitamin d deficiency 37%, and strongyloidiasis 26%. treating these diseases can prevent long-term illness.200919891864
prospective peer-review audit of paediatric upper gastrointestinal endoscopy.to describe the findings of paediatric upper gastrointestinal endoscopy (uge) and to reduce the rate of normal findings in children undergoing diagnostic uge.200717635684
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