| characterization of clinical isolates of helicobacter pylori in singapore. | of the 69 helicobacter pylori isolates analysed, 31 strains (45%) showed resistance to metronidazole, one strain (1.4%) was resistant to amoxicillin while two strains (2.9%) were resistant to clarithromycin. it was found that metronidazole resistance rates increased in singapore from 20% to 62% between late 1995 and early 1997. by biotyping using api zym, a total of 80% (55/69) strains were characterized as biotype ii, while the remaining 20% (14/69) strains belonged to biotype iii. interestingl ... | 1998 | 9785486 |
| [helicobacter pylori and upper digestive disease at the main hospital of dakar. study apropos of 105 consecutive endoscopies]. | gastro-duodenal ulcer is a very frequent disease in senegal and helicobacter pylori (hp) being an ubiquitarian germ infects people living in developing countries in an over-early way and this most frequently. we have realized a prospective study dealing with 105 adult patients sent to hospital principal's endoscopy center. we were searching for hps into three different methods which are as follows: using ordinary slats, clo-test, histological process. the results have confirmed the existence of ... | 1995 | 9827080 |
| reflux esophagitis patients in singapore have motor and acid exposure abnormalities similar to patients in the western hemisphere. | endoscopic esophagitis is less common in the east than in the west. the reason for this is unknown. this study examines prospectively the relationship between endoscopic esophagitis and lower esophageal sphincter pressure, distal esophageal contractility, esophageal peristaltic performance, esophageal acid exposure, gastric acid output, and helicobacter pylori (h. pylori) status in a consecutive series of asian patients. | 1999 | 10235190 |
| helicobacter pylori eradication with lansoprazole, amoxycillin and clarithromycin: testing an ideal regimen in a multicultural south east asian population and examining factors potentially influencing eradication. | from european and north american data, it is recommended in the asia pacific consensus statement, that one week therapy with a proton pump inhibitor, amoxycillin and clarithromycin be used for helicobacter pylori eradication, in areas of high metronidazole resistance. the efficacy of this regimen is unknown in singapore. | 2000 | 10833116 |
| a randomised trial of amoxycillin versus clarithromycin in combination with omeprazole for eradication of helicobacter pylori infection in singapore. | dual therapy has been reported to produce h.pylori eradication rate of 75-80%. this study is designed to determine the efficacy of omeprazole 20 mg bd in combination with amoxycillin 500 mg tid (group a), amoxycillin 750 mg tds (group b) and clarithromycin 500 mg tid (group c) in singapore. one hundred and forty-eight patients with h. pylori positive duodenal ulcers between ages of 22 and 69 were enrolled from two centres. there were 48 patients in group a, 50 patients in group b and 50 patients ... | 2000 | 11281438 |
| endoscopic screening for gastric cancer. | population endoscopic screening for gastric cancer is generally deemed not to be cost-effective except in japan, where its prevalence is very high. however, in the absence of screening, patients present with advanced disease, and prognosis is poor. we conducted a cost utility analysis to determine whether endoscopic screening for stomach cancer in intermediate-risk population would be cost-effective and to better define the high-risk groups in the population who would benefit from such strategy. | 2006 | 16765306 |
| cost-effectiveness analysis of helicobacter pylori screening in prevention of gastric cancer in chinese. | the aim of this study was to evaluate the costs and effectiveness associated with no screening, helicobacter pylori serology screening, and the 13c-urea breath test (ubt) for gastric cancer in the chinese population. | 2008 | 18218173 |
| 3rd college of physicians' lecture--translational research: from bench to bedside and from bedside to bench; incorporating a clinical research journey in iga nephritis (1976 to 2006). | translational research (tr) can be defined as research where a discovery made in the laboratory (bench) can be applied in the diagnosis, treatment or prevention of a disease. examples of medical discoveries contributing to translational medicine (tm) include the isolation of insulin by banting (nobel laureate, 1923), the discovery of penicillin by alexander fleming (nobel laureate, 1945) and recently the discovery of the role of bacterium helicobacter pylori in the causation of gastritis and pep ... | 2006 | 17102900 |
| nonsteroidal anti-inflammatory drug use is a significant cause of peptic ulcer disease in a tertiary hospital in singapore: a prospective study. | peptic ulcers due to nonsteroidal anti-inflammatory drug (nsaid) use may have contributed to the static prevalence of ulcer disease in asia. | 2006 | 17016134 |
| validation of four helicobacter pylori rapid blood tests in a multi-ethnic asian population. | to validate the accuracy of four rapid blood tests in the diagnosis of helicobacter pylori. | 2005 | 16425365 |
| epidemiology of helicobacter pylori infection and gastric cancer in asia. | in asia, the prevalence of helicobacter pylori (h. pylori) infection varies markedly in different countries. higher prevalence rates are found in developing asian countries while lower rates have been reported in more industrialized and developed countries. within a country, the seroprevalence rates may vary between distinct geographic regions. h. pylori infection is an important etiological factor for the occurrence of non-cardia gastric adenocarcinoma. the incidence rate of gastric adenocarcin ... | 2010 | 20370726 |
| racial differences in helicobacter pylori, serum pepsinogen and gastric cancer incidence in an urban asian population. | in singapore, the highest incidence of gastric cancer occurs in the chinese (c), with lower rates among malay (m) and indian (i) subjects. the purpose of the present paper was to examine whether racial differences in the prevalence of helicobacter pylori and serum pepsinogen (pg) could account for this difference. | 2005 | 16174081 |
| increasing trend of reflux esophagitis and decreasing trend of helicobacter pylori infection in patients from a multiethnic asian country. | this study aimed to determine time trends in the frequency of endoscopic esophagitis, and helicobacter pylori (h. pylori) infection in a large singaporean teaching hospital over a 10-yr period. | 2005 | 16128934 |
| a comparison of the clinical, demographic and psychiatric profiles among patients with erosive and non-erosive reflux disease in a multi-ethnic asian country. | to examine the clinical spectrum of gastroesophageal reflux disease (gerd) and compare erosive (erd) with non-erosive (nerd) in terms of clinical, demographic and psychiatric profiles. | 2005 | 15962374 |
| neither gastric topological distribution nor principle virulence genes of helicobacter pylori contributes to clinical outcomes. | studies on helicobacter pylori (h pylori) and gastroduodenal diseases have focused mainly on the distal sites of the stomach, but relationship with the gastric cardia is lacking. the aim of this study is to determine if the gastric topology and genotypic distribution of h pylori were associated with different upper gastrointestinal pathologies in a multiethnic asian population. | 2004 | 15484299 |
| metronidazole-resistant helicobacter pylori is more prevalent in patients with nonulcer dyspepsia than in peptic ulcer patients in a multiethnic asian population. | the trend of increasing prevalence of antibiotic resistance among helicobacter pylori strains has been suggested as a cause of the failure of treatment of h. pylori infections. in this study, 120 of 211 antral biopsy specimens from patients with dyspeptic symptoms were found to harbor h. pylori. the isolates from the 120 specimens were tested by the agar dilution method, and 38 (31.7%) were found to be metronidazole resistant. among the 211 subjects, 81 of 115 (70.4%) patients with peptic ulcer ... | 2003 | 14605132 |
| validation of 13c-urea breathtest for the diagnosis of helicobacter pylori infection in the singapore population. | several tests are available for determining the presence of helicobacter pylori (h. pylori) infection. these may be invasive or non-invasive. the carbon urea breath test (c-ubt) is generally considered to be a simple, non-invasive and accurate test for the detection of h. pylori infection both before and after treatment. commercially available 13c-ubt kits are generally validated in their country of manufacture and the stated accuracy of their tests may not be applicable to our local population. | 2002 | 12507026 |
| testing (hiv). quick test receives singapore approval. | hema-strip hiv 1/2 is a rapid hiv antibody immunoassay developed by saliva diagnostic systems, inc. (sds) which can be used by anyone who can read the product insert. the test kit is comprised of a small lancet for a finger stick, a cylindrical tube with a capillary tip and a sds diagnostic strip inside, and a vial of buffer. once blood is drawn by the lancet, the capillary tip is placed upon the blood droplet and the blood is automatically drawn into the tube. the tube is then inserted tip f ... | 1996 | 12290908 |
| is there still a role for empiric first-line triple therapy using proton pump inhibitor, amoxicillin and clarithromycin for helicobacter pylori infection in singapore? results of a time trend analysis. | this study was aimed to assess whether the efficacy of one-week triple therapy comprising of proton pump inhibitor, amoxicillin and clarithromycin (ppi/a/c) on helicobacter pylori (h. pylori) infection in singapore has decreased over the duration from 2005 to 2010. | 2013 | 23253473 |
| seroreactivity to 19.5-kda antigen in combination with absence of seroreactivity to 35-kda antigen is associated with an increased risk of gastric adenocarcinoma. | only a minority of those infected with helicobacter pylori will develop gastric cancer. stratification of h. pylori strains based on carcinogenic potential will provide a basis for selective surveillance and eradication therapy. we studied the anti-h. pylori antibody profile in asian patients with gastric adenocarcinoma to identify any h. pylori antigen that may be associated with an increased or decreased risk of gastric carcinoma. | 2002 | 12165034 |
| efficacy of a nitroimidazole containing tripletherapy regime in singapore. | there has been a gradual increase in the proportion of singapore patients with metronidazole resistant strains of helicobacter pylori. we studied the efficacy of a nitroimidazole containing regime in eradicating h. pylori. | 2001 | 11599627 |
| prevalence of helicobacter pylori in gastric cancer in a south-east asian population by 14c-urea breath test. | helicobacter pylori is believed to play an important role in the aetiology of gastric cancer. there is a great variability in seropositivity and histological frequency of h. pylori in gastric cancer. the present prospective study investigates the prevalence of h. pylori infection in gastric cancer patients using 14c-urea breath testing. | 2001 | 11552930 |
| prevalence of helicobacter pylori in peptic ulcer disease in a singapore hospital. | high helicobacter pylori (h. pylori) prevalence is well documented among peptic ulcer patients. however, there have been recent reports of declining h. pylori infection rates in developed countries. based on previous local data in a different hospital, h. pylori prevalence was 66% in gastric ulcer, 86% in duodenal ulcer and 75% in combined gastric and duodenal ulcers. our present study aims to review the recent h. pylori prevalence in peptic ulcer patients in a singapore hospital. h. pylori infe ... | 2000 | 11281437 |
| helicobacter pylori infection and its treatment in singapore. | | 2000 | 11281436 |
| recurrence of helicobacter pylori infection and duodenal ulcer relapse, following successful eradication in an urban east asian population. | we aimed to determine the rate of helicobacter pylori (hp) recurrence and duodenal ulcer relapse in patients of a hospital in singapore over a period of at least one year from the time of eradication. ninety-six consecutive duodenal ulcer patients with biopsy-proven hp eradication and healed ulcer were seen at 3-month intervals, and follow-up endoscopy was performed when dyspepsia recurred, at the end of one year after eradication, or at the time of recall if the patient had been lost to follow- ... | 2000 | 11256345 |
| the status of the caga gene does not predict helicobacter pylori-associated peptic ulcer disease in singapore. | discrepancies among reports from different geographical regions worldwide on the association between the presence of caga and peptic ulcer disease prompted this study on the predictive value of the caga gene in helicobacter pylori-associated gastroduodenal diseases in the singapore population. h. pylori strains were obtained from 169 patients with a peptic ulcer, 83 with non-ulcer dyspepsia, and nine with gastric cancer. the presence of the caga gene was evaluated by polymerase chain reaction (p ... | 2000 | 10885501 |
| helicobacter pylori infection--current status in singapore. | helicobacter pylori infection is a common infection in singapore affecting about 31% of the population. the seroprevalence of h. pylori infection increases with age from 3% in children below 5 years to 71% in adults above 65 years. amongst the races, chinese and indians had similar rates of seropositivity (34.3% and 33.6%) while in malays it was significantly lower (13.7%; p < 0.05). h. pylori infection is associated with peptic ulcer disease (both duodenal and gastric ulcer) as well as gastric ... | 1997 | 9494671 |
| racial differences in helicobacter pylori seroprevalence in singapore: correlation with differences in peptic ulcer frequency. | the aim of this study was to determine, first, whether racial differences exist in the seroprevalence of helicobacter pylori infection in singapore, and second, whether these differences correlate with racial differences in peptic ulcer frequency. a commercial serological test for immunoglobulin (ig)g antibody to h. pylori which was 90% sensitive and 83% specific in our population was used to screen 403 adult blood donors of chinese, malay and indian origin, aged between 15-60 years. serum speci ... | 1997 | 9407329 |
| working party report of the gastroenterological society of singapore. part ii--helicobacter pylori and non-ulcer dyspepsia in singapore. | non-ulcer dyspepsia (nud) is a common symptom whose cause is currently unclear. helicobacter pylori (h pylori) infection is found in half of all patients with nud but other pathophysiological abnormalities eg delayed gastric emptying, have also been described. nud patients with or without h pylori infection have identical symptom patterns and pathophysiological parameters. studies on the efficacy of h pylori treatment in nud give equivocal results to date. we therefore do not recommend treatment ... | 1996 | 8993148 |
| working party report of the gastroenterological society of singapore. part i--helicobacter pylori and peptic ulcer disease in singapore. | the gastroenterological society working party on helicobacter pylori (h pylori) recommends eradication of h pylori in patients with peptic ulcer, provided h pylori infection has been demonstrated. h pylori treatment is not indicated for non-ulcer dyspepsia, histological gastritis or mere demonstration of h pylori infection. h pylori infection can be demonstrated by a urease test, culture or histological assessment on gastric antral biopsy or by a 13c and 14c urea breath test: serology is accepta ... | 1996 | 8942236 |
| prolonged treatment with omeprazole does not improve the eradication rate of helicobacter pylori infection--a short report [corrected]. | omeprazole has been shown to have a suppressive effect on helicobacter pylori. the aim of this study was to determine if prolonged treatment with omeprazole would result in a higher eradication rate than short course treatment. twenty patients with endoscopy proven duodenal ulcers and unequivocal evidence of helicobacter pylori (hp) infection based on culture, histology, urease test and gram's stain of a fresh tissue smear were treated with omeprazole 40 mg om for 2-4 weeks. following ulcer heal ... | 1995 | 8781634 |
| helicobacter pylori and gastritis in patients with peptic ulcer and non-ulcer dyspepsia: ethnic differences in singapore. | peptic ulcer occurs with different frequencies in the three main racial groups in singapore. this study aimed firstly to determine the prevalence of helicobacter pylori in peptic ulcer and non-ulcer dyspepsia patients of the different races and secondly, to assess the relation between h pylori, histological gastritis, patient diagnosis, and race. gastric antral biopsy specimens from 1502 patients undergoing gastroduodenoscopy were studied and 892 (59%) were positive for h pylori. h pylori was st ... | 1990 | 2387503 |
| distinct caga epiya motifs are associated with ethnic diversity in malaysia and singapore. | in vitro studies have shown that the biologic activity of caga is influenced by the number and class of epiya motifs present in its variable region as these motifs correspond to the caga phosphorylation sites. it has been hypothesized that strains possessing specific combinations of these motifs may be responsible for gastric cancer development. this study investigated the prevalence of caga and the epiya motifs with regard to number, class, and patterns in strains from the three major ethnic gr ... | 2009 | 19674129 |
| cost effectiveness analysis of population-based serology screening and (13)c-urea breath test for helicobacter pylori to prevent gastric cancer: a markov model. | to compare the costs and effectiveness of no screening and no eradication therapy, the population-based helicobacter pylori (h pylori) serology screening with eradication therapy and (13)c-urea breath test (ubt) with eradication therapy. | 2008 | 18494053 |
| genetic factors associated with intestinal metaplasia in a high risk singapore-chinese population: a cohort study. | intestinal metaplasia (im) is an important precursor lesion in the development of gastric cancer (gc). the aim of this study was to investigate genetic factors previously linked to gc risk for their possible association with im. a total of 18 polymorphisms in 14 candidate genes were evaluated in a singapore-chinese population at high risk of developing gc. | 2009 | 19822020 |
| the cag pai is intact and functional but hp0521 varies significantly in helicobacter pylori isolates from malaysia and singapore. | helicobacter pylori-related disease is at least partially attributable to the genotype of the infecting strain, particularly the presence of specific virulence factors. we investigated the prevalence of a novel combination of h. pylori virulence factors, including the cag pathogenicity island (pai), and their association with severe disease in isolates from the three major ethnicities in malaysia and singapore, and evaluated whether the cag pai was intact and functional in vitro. polymerase chai ... | 2010 | 20157752 |
| variation in human genetic polymorphisms, their association with h pylori acquisition and gastric cancer in a multi-ethnic country. | background and aim: the contribution of human genetic polymorphisms to h. pylori infection and gastric cancer (gc) development remains unclear due to geographic variation in the association between specific host genetic polymorphisms and gc. in the current study we investigated the association between polymorphisms related to immune and cancer-related pathways and h. pylori infection among the major ethnicities, chinese, malay and indian, resident in singapore and malaysia as well as the associa ... | 2011 | 21649724 |
| composite protective lifestyle factors and risk of developing gastric adenocarcinoma: the singapore chinese health study. | incidence of gastric cancer is the highest in eastern asia. multiple modifiable lifestyle factors have been identified as risk factors for gastric cancer. however, their aggregated effect on the risk of gastric cancer has not been examined among populations with high prevalence of helicobacter pylori. | 2017 | 28125822 |
| nonbismuth concomitant quadruple therapy for helicobacter pylori eradication in chinese regions: a meta-analysis of randomized controlled trials. | to evaluate the applicability of nonbismuth concomitant quadruple therapy for helicobacter pylori (h. pylori) eradication in chinese regions. | 2016 | 27340362 |
| low serum albumin may predict the need for gastric resection in patients with perforated peptic ulcer. | perforated peptic ulcer (ppu) is a common surgical emergency and treatment involves omental patch repair (pr). gastric resection (gr) is reserved for difficult pathologies. we audit the outcomes of gr at our institution and evaluate the pre-operative factors predicting the need for gr. | 2016 | 27074924 |
| the changing profile of helicobacter pylori antibiotic resistance in singapore: a 15-year study. | antibiotic resistance is an important cause of h. pylori treatment failure. this study aimed to examine the change in h. pylori antibiotic resistance profile in singapore over the course of 15 years. | 2016 | 26774006 |
| the use of a second biopsy from the gastric body for the detection of helicobacter pylori using rapid urease test. | the use of an additional biopsy from the gastric body may help improve the detection of helicobacter pylori during endoscopy. this study aimed to determine whether such an additional biopsy is necessary in routine rapid urease test (rut), and whether acid suppression and antibiotic therapy affect rut results. | 2014 | 25630318 |
| coffee intake and gastric cancer risk: the singapore chinese health study. | despite experimental evidence showing chemopreventive effects of coffee-related compounds on gastric carcinogenesis, epidemiologic studies generally do not support coffee-gastric cancer associations. observational data are lacking among high-risk populations with sufficient regular coffee consumption. | 2014 | 24608187 |
| the diagnosis and management of h. pylori infection in singapore. | helicobacter pylori (h. pylori) is an infection that has a role in causing dyspepsia and complications such as peptic ulcer disease and gastric malignancies. in the primary care setting, one can adopt a stepwise approach with the 'test-and-treat' strategy to manage h. pylori-associated dyspepsia in young patients without alarm symptoms. empiric first-line therapies should be for a two-week duration; options include clarithromycin-containing triple therapy alone or with the addition of bismuth, c ... | 2017 | 28536725 |