lack of consistency in the associations of helicobacter pylori seropositivity with se and le polymorphisms among our previous study, a marked association between helicobacter pylori seropositivity and functional polymorphisms of the secretor and lewis genes (odds ratio [or], 0.32; 95% confidence interval [ci], 0.14-0.70 for se/se genotype relative to se/se genotype; and or, 10.3; 95% ci, 3.16-33.8 for high-risk group defined by the combination of se and le relative to low-risk group) had been observed for 239 non-cancer japanese outpatients of the gastroenterology clinic (ogc) undergoing gastroscopy at ...200212491076
significant association of runx3 t/a polymorphism at intron 3 (rs760805) with the risk of gastric atrophy in helicobacter pylori seropositive japanese.this study aimed to examine the associations of a runx3 t/a polymorphism at exon 1 (asn18ile) (rs6672420) and another runx3 intronic t/a polymorphism (rs760805) with the risk of gastric cancer together with the risk of h. pylori seropositivity and gastric atrophy in japanese people.200919728008
no association between aicda 7888 c/t polymorphism, helicobacter pylori seropositivity, and the risk of atrophic gastritis and gastric cancer in japanese.the aberrant expression of activation-induced cytidine deaminase (aicda) was reportedly induced in gastric epithelial cells infected with cytotoxin-associated gene a (caga)-positive helicobacter pylori, resulting in the accumulation of alterations in the tp53 tumor suppressor gene in gastric cells. we investigated the association of the aicda 7888 c/t polymorphism with h. pylori infection and the risk of gastric cancer and atrophic gastritis in japanese subjects.201020373075
associations of a ptpn11 g/a polymorphism at intron 3 with helicobactor pylori seropositivity, gastric atrophy and gastric cancer in japanese.previous studies have revealed the significance of helicobacter pylori (h. pylori) infection as a risk factor of gastric cancer. cytotoxin-associated gene a (caga) positivity has been demonstrated to determine the clinical outcome of h. pylori infection in the presence of shp-2 (src homology 2 domain-containing protein tyrosine phosphatase-2). this study aimed to examine the formerly reported association of g/a ptpn11 (protein-tyrosine phosphatase, nonreceptor-type 11) polymorphism (rs2301756) w ...200919589142
[association between the interleukin 1b (c-31t) polymorphism and helicobacter pylori infection in health checkup examinees].associations between helicobacter pylori (hp) infection and lifestyle factors have been demonstrated by several studies, but there are very few reports on links with host factors, especially concerning genetic polymorphisms for inhabitants of large city. the present investigation was conducted to determine the hp infection rate with reference to the interleukin-1 beta gene (il-1b) polymorphism and assess the interactions with smoking reported for outpatients.200111579484
no associations of toll-like receptor 2 (tlr2) -196 to -174del polymorphism with the risk of helicobacter pylori seropositivity, gastric atrophy, and gastric cancer in japanese.recently, the association between gastric cancer risk and a functional polymorphism of toll-like receptor 2 (tlr2), -196 to -174del, was reported for a japanese population. this study aimed to confirm the associations of the polymorphism with the risk of gastric cancer, as well as helicobacter pylori seropositivity and the risk of gastric atrophy in japanese.201021128061
advances in cancer epidemiology in japan.epidemiologists in japan have been performing calculations to estimate nationwide cancer incidence rates as well as 5-year survival rates using population-based cancer registry data. there have been remarkable changes in cancer incidence and/or mortality in cancers of the lung, liver and stomach, which were thought to be attributed to the changing impact of exposure to cigarette smoking, chronic hepatitis c virus infection and helicobacter pylori infection, respectively. in systematic reviews pr ...201424105756
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