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increased risk of helicobacter pylori associated with birth in wartime and post-war japan.helicobacter pylori infection is now widely recognized as a cause of stomach cancer. we assessed trends in h. pylori infection in japan, a population with high rates of gastric malignancy.19968666492
changes in seroepidemiological pattern of helicobacter pylori and hepatitis a virus over the last 20 years in japan.the age groups most susceptible to infection and the mode of transmission of helicobacter pylori (h. pylori) are not yet clear. to contribute to a better understanding of this disease, this study was undertaken to evaluate changes in the seroepidemiological pattern of h. pylori in a group of japanese people over the last 20 yr sampled in 1974, 1984, and 1994 in comparison with that of the hepatitis a virus (hav), which was used as a marker of the fecal-oral route of transmission.199910445533
helicobacter pylori dna in drinking water in japan.helicobacter pylori has been detected in drinking water in peru and sweden, suggesting the possibility of water-borne transmission. to date there have been few reports of h. pylori being detected in water; one was of the urea gene of h. pylori in wells and springs in rural japan. we examined water sampled in or near urban areas of japan for h. pylori dna by three assays using the polymerase chain reaction (pcr). near tokyo, samples were obtained: 10 of tap water, 6 of well water, 10 of river wat ...200111529557
proceedings of the rokuzo kobayashi memorial symposium on helicobacter pylori. may 11, 2002, tokyo, japan. 200212602369
amoxicillin resistance in helicobacter pylori: studies from tokyo, japan from 1985 to 2003.previous reports revealed no resistant strains of amoxicillin (ampc), which is usually used in eradication therapy for h. pylori infection. however, the frequency and evolution of natural ampc-resistant strains in the japanese population remains unknown.200515691310
trends of second-line eradication therapy for helicobacter pylori in japan: a multicenter study in the tokyo metropolitan area.in japan, the eradication rate of first-line therapy for helicobacter pylori (h. pylori) with a proton pump inhibitor (ppi), amoxicillin (ampc) and clarithromycin (cam) has been decreasing because of a high prevalence of cam resistance. a possible decrease of the eradication rate for second-line therapy with a ppi, ampc and metronidazole (mnz) is of concern. the aim of this study is to assess the trends in second-line eradication therapy for h. pylori in japan.201323773231
changes in the first line helicobacter pylori eradication rates using the triple therapy-a multicenter study in the tokyo metropolitan area (tokyo helicobacter pylori study group).helicobacter pylori (h. pylori) infection is a strong risk factor for the development of gastric cancer. in 2013, the japanese government approved h. pylori eradication therapy in patients with chronic gastritis as well as peptic ulcer. however, the continuing decline in eradication rates for first-line h. pylori eradication therapies is an urgent problem. in this study, we investigated changes in the first-line eradication rate from 2001 to 2010.201425521730
eight-year follow-up of patients with immune thrombocytopenic purpura related toh. pyloriinfection.thrombocytopenia related to helicobacter pylori infection is a definitive subset of chronic immune thrombocytopenic purpura (itp) but its long-term prognosis has not been evaluated extensively. the possibility of recurrence of thrombocytopenia after re-infection of h. pylori is another concern. we evaluated 8-year follow-up data for 11 patients with itp related to h. pylori infection in a single institution. in 2001, patients with chronic itp were evaluated for h. pylori infection at the tokyo m ...201020942598
changes in the presence of urine helicobacter pylori antibody in japanese children in three different age groups.the rates of acquisition and spontaneous eradication of helicobacter pylori infection in children has yet to be established. to determine these rates in children living in an urban region of japan, the levels of urine h. pylori antibodies in children of three different age groups were measured.200818533939
why does japan have a high incidence of gastric cancer? comparison of gastritis between uk and japanese patients.the incidence of gastric cancer in japan is four times higher than in the uk. it usually arises in a stomach with corpus predominant or pangastritis that has undergone extensive atrophy and intestinal metaplasia. we hypothesised that a japanese population would have a more severe gastritis with a corpus predominant or pangastritis pattern and a greater degree of atrophy and intestinal metaplasia than that found in the uk. to test this we designed a comparative trial.200616603635
a case-control study exploring the role of serum manganese superoxide dismutase (mnsod) levels in gastric cancer.the role of serum manganese superoxide dismutase (mnsod) in the development of gastric cancer has not been clearly defined.200515930805
susceptibilities to clarithromycin, amoxycillin and metronidazole of helicobacter pylori isolates from the antrum and corpus in tokyo, japan, 1995-2001.the aim of this study was to determine the susceptibilities to clarithromycin, amoxycillin and metronidazole of helicobacter pylori isolates from the antrum and corpus of japanese patients examined during the period 1995-2001. there was an increase, from 6.2% in 1995 to 22.1% in 2000-2001, in the proportion of patients infected with clarithromycin-resistant h. pylori. of patients infected with clarithromycin-resistant h. pylori, 39.1% were infected with both clarithromycin-susceptible and -resis ...200515760428
helicobacter pylori infection, mucosal atrophy and intestinal metaplasia in asian populations: a comparative study in age-, gender- and endoscopic diagnosis-matched subjects.it is known that the incidence and mortality rate of gastric cancer is high among japanese and chinese populations, but extremely low in thai and vietnamese populations. the aim of this study was to investigate the prevalence of helicobacter pylori infection and the differences in the glandular atrophy and intestinal metaplasia scores in stomach specimens of asian adult subjects of different races.200312603614
inhibitory action of a novel proton pump inhibitor, rabeprazole, and its thioether derivative against the growth and motility of clarithromycin-resistant helicobacter pylori.clarithromycin-resistant helicobacter pylori (crhp) has increasingly been isolated from patients in japan. the aim of our study was to test whether proton pump inhibitors (ppis) and their thioether derivatives, which are secreted into the gastric mucosa, could inhibit the growth and motility (a factor in colonization) of crhp.200111422467
helicobacter pylori infection, serum pepsinogen level and gastric cancer: a case-control study in japan.we conducted a case-control study to evaluate the effect of helicobacter pylori (hp) infection on the risk of gastric cancer in tokyo, japan. the sera at the time of diagnosis from 282 gastric cancer cases and 767 sex- and age-matched cancer-free controls were tested for the presence of anti-hp igg antibody (hm-cap elisa kit) and serum pepsinogen (pg) level (pg i and pg ii riabead). no significant association was observed in all sets [matched odds ratio (or) = 1.04, 95% confidence interval: 0.73 ...19957737912
efficacy of metronidazole as second-line drug for the treatment of helicobacter pylori infection in the japanese population: a multicenter study in the tokyo metropolitan area.with the increase in the frequency of clarithromycin-resistant helicobacter pylori (h. pylori), there is rising concern about the decline of the eradication rate of this infection following treatment. the tokyo hp study group examined the eradication rate in response to a second-line regimen consisting of proton pump inhibitor (ppi), amoxicillin, and metronidazole by conducting a multicenter study in the tokyo metropolitan area.200616684262
helicobacter pylori infection among patients visiting a clinic in kasama city, ibaraki prefecture.we examined helicobacter pylori infection in patients who visited the iso clinic (kasama city, ibaraki prefecture) with abdominal complaints, and determined the prevalence of h. pylori infection by age, sex, endoscopic diagnosis, abdominal complaint, gastric mucosa, and living environment. peptic ulcer disease was observed in 23.2% of the patients examined with endoscopy, but there was no association between abdominal complaints and the prevalence of h. pylori infection. the prevalence of h. pyl ...200516415514
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