relationship between histopathological status of the helicobacter pylori infected patients and proteases of h. pylori in isolates carrying diverse virulence genotypes.helicobacter pylori is the main cause of several gastroduodenal diseases in humans. among various virulence factors of h. pylori, proteases may also be involved in its pathogenicity. in this study, relationship between proteolytic activity of h. pylori strains and histopathological changes of the stomach was investigated in the patients infected with strains carrying diverse virulence factors. h. pylori strains were isolated from the biopsies of 116 patients who referred to hospital for their ga ...201728629725
analysis of helicobacter pylori genotypes in afghani and iranian isolates.the geographical variation in helicobacter pylori genotypes is an observed phenomenon. cytotoxin associated genes a (caga) and e (cage), and vacuolating cytotoxin (vaca) genotypes of h. pylori are associated with peptic ulcer disease (pud). this study compared the distribution of these genotypes in iranian and afghani isolates and their association with clinical outcomes. h. pylori infected patients, as proven by positive culture, were recruited prospectively. a total of 70 patients, 55 iranian ...201020568532
the prevalence of caga and cage genes in helicobacter pylori strains isolated from different patient groups by polymerase chain reaction.the aim of this study was to investigate the prevalence of caga and cage genes in h. pylori strains isolated from different patient groups with non-ulcer dyspepsia (nud), duodenal ulcer (du), gastric ulcer (gu) and gastric cancer (gc). the patients admitted to the gastroenterology unit at sharyati hospital in tehran in 2006 were included in this study. gastric biopsy specimens were obtained from the antrum of the stomach from each patient then cultured for detection of h. pylori. identification ...200819260336
childhood hygienic practice and family education status determine the prevalence of helicobacter pylori infection in of helicobacter pylori, a causative agent of gastrointestinal diseases is an important health problem in most countries. the main reasons include poorly defined epidemiological status and unrecognized mode of bacterial transmission. our objective was to investigate the prevalence of h. pylori infection in a representative population of iran and to evaluate possible risk factors for the h. pylori infection.200919191895
distribution of helicobacter pylori caga, cage, oipa and vaca in different major ethnic groups in tehran, iran.there are geographical variations in helicobacter pylori virulence genes; caga, cage, vaca and oipa. the present study compared the distribution of these genotypes in major ethnic groups residing in tehran, iran and their association with clinical outcomes.200919702906
unfavorable survival rates in iranian patients with gastric cancers: a single center experience from tehran.we examined the effect of potential interfering factors that play major roles in the outcome of our patients with stomach cancer. 100 consecutive patients diagnosed with gastric cancers were prospectively observed, treated and followed from november 2009 to january. absence of helicobacter pylori infection (p=0.027), absence of vascularisation (p<0.001), and undetermined histopathological type of adenocarcinoma (p=0.003) were factors significantly associated with higher grade of gastric lesions. ...201424901724
vaca genotypes of helicobacter pylori in relation to caga status and clinical outcomes in iranian populations.mosaicism in vaca alleles with two distinct families of vaca signal sequences (s1 and s2) and two distinct families of middle region alleles (m1 and m2) has been reported. research suggests that the vaca s1 genotype is closely associated with duodenal ulcer disease and with high cytotoxin production. the aims of this study were to evaluate the role of vaca genotyping with respect to gastric inflammation and injury, and clinical presentation in iranian populations. genomic dna of biopsy specimens ...200818653971
association between iron deficiency anemia and helicobacter pylori infection among children under six years in iran.this study was conducted to evaluate the association between h. pylori infection and iron deficiency anemia (ida) among preschool children (age range: 40-75 months) at a tertiary referral hospital in a case-control study, the prevalence of h. pylori seropositivity was compared between 64 children with ida diagnosis and 70 healthy non-anemic sex- and age-matched controls. totally, 52 (81.3%) children with ida and 10 (14.3%) non-anemic controls had a positive antibody level for h. pylori ...201525871019
helicobacter pylori antibiotic resistance in examine the frequency of antibiotic resistance in iranian helicobacter pylori (h pylori) strains isolated from two major hospitals in tehran.200516273615
cancer incidence in tehran metropolis: the first report from the tehran population-based cancer registry, 1998-2001.there are no population-based data available for cancer in tehran, a city that includes almost 10% of the iranian population. this is the first report of cancer incidence in tehran from a population-based cancer registry for the period of 1998-2001.200919111024
identification of a novel cassette array in integronbearing helicobacter pylori strains isolated from iranian patients.helicobacter pylori as the second most common cause of gastric cancer in the world infects approximately half of the developed countries population and 80% of the population living in developing countries. integrons as genetic reservoirs play major roles in dissemination of antimicrobial resistance genes. to the best of our knowledge, this is the first study to report carriage of class 1 and 2 integrons and associated gene cassettes in h. pylori isolates from iran. this crosssectional study was ...201627509968
helicobacter pylori infection and postoperative nausea and vomiting.the aim of this study was to identify factors most relevant to postoperative nausea and vomiting (ponv) and determine the association of helicobacter pylori with ponv.200818705288
application of a stool antigen test to evaluate the incidence of helicobacter pylori infection in children and adolescents from tehran, iran.helicobacter pylori infection is acquired mainly in childhood, especially in developing countries, where a low-cost, rapid diagnostic technique which is reliable for all age groups may be useful for the management of h. pylori infection. for this purpose, we used an hpsa test (equipar) to detect h. pylori infection in children and adolescents from tehran, iran. thirty-five children who were positive or negative for h. pylori infection by endoscopy-based tests were used as positive and negative c ...200516148176
relationship between helicobacter pylori infection and serum ferritin level in primary school children in tehran-iran.iron deficiency can cause cognitive and functional learning disorders in children. some studies have reported a relationship between low serum ferritin levels in patients with anemia and helicobacter pylori (h. pylori) infection. therefore, we aimed to determine the relationship between these two common diseases. this descriptive analytical cross-sectional study was performed to assess serum ferritin levels and h. pylori antibody titers (igg) among 6-12 year old healthy primary school children i ...201121713752
gastro-oesophageal reflux disease and irritable bowel syndrome: a significant association in an iranian population.gastro-oesophageal reflux disease and irritable bowel syndrome are common diseases, which may be related.200818617775
Relationship between Helicobacter pylori infection and serum ferritin level in primary school children of Tehran-Iran.To determine the relationship between serum Ferritin levels and Helicobacter pylori antibody titer (IgG) in primary school children with H.pylori infection.201122204240
antibiotic susceptibility profile of helicobacter pylori isolated from the dyspepsia patients in tehran, iran.helicobacter pylori is an important pathogen for gastroduodenal diseases. infection with h. pylori can be limited by regimens of multiple antimicrobial agents. however, antibiotic resistance is a leading cause of treatment failure. the aim of this study has been to determine the resistance patterns of h. pylori strains isolated from gastric biopsies of patients with dyspepsia by agar dilution method, in tehran, iran. patients and methods : h. pylori isolates from patients with gastrointestinal d ...201121727733
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