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protective titres of measles neutralising antibody.a nation-wide measles outbreak occurred in 1988 in taiwan. a retrospective cohort study was conducted to define the protective titre of measles neutralising (nt) antibody. paired sera collected in 1987 and 1988 were available from 190 individuals born in 1984 who had participated in an annual hepatitis b immunisation follow-up from 1986 to 1991. measles nt titres were quantified using a standardised neutralisation enzyme immunoassay. measles infection was defined as a >/=4-fold rise in nt titre ...200011074481
seroepidemiology and evaluation of passive surveillance during 1988-1989 measles outbreak in taiwan.a seroepidemiological study was carried out to explore the risk factors of a measles outbreak that occurred among school children at a rural village (li-tse) in taiwan. among the 1166 participants, the percentage susceptible before the outbreak was 10.5% (122/1158) which was estimated as the sum of measles igg-negative (29/1158) and igm-positive (93/1166) individuals. among 340 vaccinated children, 16 (4.7%) were measles igm-positive and 10 (2.9%) were measles igg-negative; therefore the vaccine ...19921483823
molecular epidemiology of measles virus in taiwan in 2010-2011: the common genotype changed from h1 to d9 and the first appearance of d4.measles has been controlled effectively in some countries because of high coverage rates with an effective vaccine. however, measles outbreaks still occasionally occur in areas with high vaccine coverage as a result of imported transmission. to identify the sources of measles infection and to determine whether measles cases are part of a single outbreak or due to multiple importations, measles virus (mv) genotyping is required and plays an important role in mv elimination. in taiwan, genotype h1 ...201323588738
measles surveillance in taiwan, 2012-2014: changing epidemiology, immune response, and circulating genotypes.in taiwan, although the coverage rate of two doses of measles-containing vaccine has been maintained at over 95% since 2001, measles outbreaks occurred in 2002, 2009, and 2011. the present study reports that 43 cases were confirmed by laboratory testing in taiwan in 2012-2014 and that adults have emerged as one of groups susceptible to measles virus (mv) infection, who may have discrepant humoral immune reactions--indicated by the level of igm and igg antibodies compared to a naïve, susceptible ...201626400063
changes in measles seroepidemiology of healthcare workers in southern taiwan.summaryto assess the measles seroepidemiology of healthcare workers (hcws), from 2004 to 2009 all newly recruited staff at a university hospital in taiwan, were tested for specific immunoglobulin g antibodies for measles virus using enzyme-linked immunosorbent assays. a total of 1584 hcws were included. the positivity rate of measles antibody for physicians and nurses was about 90%. the positivity of measles antibody in different age groups was 78·1%, 93·9% and 94·2% for 20-29, 30-39 and ⩾40 yea ...201121489337
molecular evolution of measles viruses circulated in taiwan 1992-2008.genetic analyses of viral samples from 74 laboratory confirmed measles cases occurring in taiwan during 1992-2008 identified six viral genotypes d3, d5, d9, g2, h1 and h2. the most frequently detected genotype, h1, was associated with outbreaks in 1994 and 2002, and was the likely indigenous genotype in 1992. in response to the outbreaks, two catch-up campaigns were launched and a routine second dose of measles, mumps, and rubella vaccine at entry to elementary school was introduced. the vaccina ...200920003242
nosocomial transmission of undetected, imported measles in taiwan, 2008. 200919737092
modified measles in a healthcare worker after return from travel. 200818462155
humoral and cellular immune response after measles vaccination in taiwan.measles immunoglobulin g (igg) seroepidemiologic studies have been widely used to monitor the effectiveness of measles immunization programs in taiwan. however, studies about cellular immunity against the measles virus have been lacking. this study surveyed cellular immunity after measles, mumps and rubella combined vaccine (mmr) immunization in taiwan. seventy six people between 1 and 80 years of age were enrolled. all patients lived in northern taiwan, and none of them had immunodeficient dise ...200515986066
measles igg seroprevalence prior to mass vaccination in taiwan.measles vaccine was licensed for use in taiwan in 1968 and mass vaccination has been implemented since 1978. serological surveys were conducted to characterize measles seroepidemiology prior to mass vaccination.200212044301
measles seroepidemiology and decay rate of vaccine-induced measles igg titers in taiwan, 1995-1997.community-based seroepidemiologic studies were conducted to monitor the effectiveness of measles immunization programmes and to estimate the decay rate of vaccine-induced measles igg titres. sera collected from a mountain (792 sera), rural (875 sera) and urban (894 sera) populations in 1995-1997 were available. measles igg was quantified using a commercial eia kit. measles igg seroprevalence and geometric mean titre (gmt) were calculated by setting the cut-off titre at 50 miu/ml. the decay rate ...200111535312
predicting and comparing long-term measles antibody profiles of different immunization policies.measles outbreaks are infrequent and localized in areas with high coverage of measles vaccine. the need is to assess long-term effectiveness of coverage. since 1991, no measles epidemic affecting the whole island has occurred in taiwan, china. epidemiological models are developed to predict the long-term measles antibody profiles and compare the merits of different immunization policies on the island.200111477964
genetic analysis of asian measles virus strains--new endemic genotype in nepal.in many parts of asia measles virus (mv) continues to be endemic. however, little is known about the genetic characteristics of viruses circulating on this continent. this study reports the molecular epidemiological analysis based on the entire nucleocapsid (n) and hemagglutinin (h) genes of the first isolates from nepal and taiwan, as well as of recent mv strains from india, indonesia, and china. four isolates collected in various regions in nepal during 1999 belonged to a new genotype, tentati ...200111376847
post mass-immunization measles outbreak in taoyuan county, taiwan: dynamics of transmission, vaccine effectiveness, and herd immunity.analysis of national surveillance data and a seroepidemiologic investigation were conducted to elucidate the causes and epidemiologic characteristics of a measles outbreak in taoyuan, taiwan, 1994.199810225982
identification of a measles virus isolate from a recent outbreak in northern taiwan.specimens were collected during a recent outbreak. those specimens displaying both cpe positive in b95-8 lymphocyte cell culture and positive by ifa were checked by a rt-pcr with a specific set of measles virus primers derived from the c-terminal of the nucleoprotein. such rt-pcr method was found ideal for routine diagnostic purposes. product from this rt-pcr was treated for plasmid construction before transformed into e. coli. one of those transformed clones, i. e. t94, was further studied for ...19979309872
seroepidemiological study of measles after the 1992 nationwide mmr revaccination program in taiwan.the incidence of measles declined rapidly in taiwan after the introduction of the measles vaccine into the routine immunization schedule in 1978. however, an epidemic still occurred every 3-5 years until recently. a nationwide measles-mumps-rubella (mmr) revaccination program for school and preschool children has been in place since 1992 to control the indigenous transmission of measles. in order to understand the current immune status after this recent nationwide revaccination program, we deter ...19978986946
imported measles and implications for its elimination in taiwan.during november 2008-may 2009, an outbreak of 53 measles cases occurred in taiwan. of these, 3 cases were sporadic, and the other 50 cases could be grouped into 8 clusters by genetic analysis. we determined 7 h1 genotypes linked to importation and 1 g3 genotype linked to an untraceable source.201121801641
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